Gait and Alzheimer Interaction Tracking (GAIT) Study

NCT01315717 | Completed DMC

• 1 other identifier: 2009-A00533-54
• Study Type: observational
• Target: 912
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).

Conditions

Gait Apraxia; Alzheimer Disease; Impaired Cognition; Cerebral Atrophy

Outcome Measures

Primary Outcomes (1)

• Stride-to-stride variability of stride time

  baseline

Study Arms (4)

Group 1

Healthy subjects

Group 2

Patients with Mild Cognitive Impairment

Group 3

Patients with Mild AD

Group 4

Patients with Moderate AD

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients of the University Memory Center of Angers Hospital with respect to the eligibility criteria.

You may qualify if:

• Age ≥ 60 years
• Able to walk without walking aid on 15 metres
• Score of Mini-Mental Examination (MMSE) \> 10
• Written informed consent to participate in the study (or trustworthy person)
• Being affiliated to a social security regime
• Near visual acuity ≥ 2/10
• Absence of severe depression (score in the 15-item Geriatric Depression Scale ≤ 10)

You may not qualify if:

• Score of Mini-Mental Examination (MMSE) ≤ 10
• Subject suffering from pre-existing impellent disturbances
• History of cerebrovascular accident or other cerebro-spinal pathology
• Poor workmanship of the written or oral French language
• Refusal of subject to be informed on possible hanging bare anomaly during study
• Use of walking aid
• Acute medical or surgical disease in the past 3 months
• Refusal to participate (or trustworthy person)
• Contra-indication to the achievement of a Magnetic Resonance Imaging
• Near visual acuity \< 2/10
• Presence of severe depression (score in the 15-item Geriatric Depression Scale \> 10)

Sponsors & Collaborators

• University Hospital, Angers: lead

Study Sites (1)

Angers University Hospital

Angers, 49933, France

Location

Related Publications (1)

• Graffe A, Beauchet O, Fantino B, Milea D, Annweiler C. Vitamin D and macular thickness in the elderly: an optical coherence tomography study. Invest Ophthalmol Vis Sci. 2014 Jul 15;55(8):5298-303. doi: 10.1167/iovs.14-13918.

  PMID: 25028353 DERIVED

MeSH Terms

Conditions

Gait Apraxia; Alzheimer Disease; Cognition Disorders

Condition Hierarchy (Ancestors)

Gait Disorders, Neurologic; Neurologic Manifestations; Nervous System Diseases; Apraxias; Psychomotor Disorders; Neurobehavioral Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Dementia; Brain Diseases; Central Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Olivier Beauchet, MD, PhD

  Angers University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2011
• First Posted: March 15, 2011
• Study Start: November 1, 2009
• Primary Completion: May 1, 2016
• Study Completion: May 1, 2016
• Last Updated: September 22, 2016

Record last verified: 2011-03

Locations

FR (1)