Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects

NCT00951197 | Completed

• 1 other identifier: CHUBX2008/13
• Study Type: observational
• Target: 318
• Locations: 1 country
• Sites: 1

Brief Summary

Capturing the earliest stages of Dementia especially Alzheimer's Disease (AD) is a great challenge. Until now the NINCDS-ADRDA and the DSM criteria for AD were largely used as diagnostic standards in research. However, the research on AD progresses and some biomarkers have been recently suggested to improve the diagnostic criteria of AD, such as cerebrospinal fluid markers, neuroimaging with Positon Emission Tomography (PET) or Magnetic Resonance Imaging (MRI).

Conditions

Dementia; Alzheimer Disease

Keywords

dementia; Alzheimer's Disease; diagnostic; biomarkers; neuroimaging; PET; MRI; mild cognitive impairment

Outcome Measures

Primary Outcomes (1)

• FA (Fractional Anisotropy), MTR (magnetization transfer ratio) and T2 (Transverse relaxation time) measures in patients with dementia compared to controls, in left and right hippocampus, and posterior cingulum

  day 0

Secondary Outcomes (3)

• FA, MTR and T2 measures in subjects with mild cognitive impairment no dementia

  day 0

• Performances in the 7 neuropsychological tests available in the AMI cohort

  day 0

• FA measures for the connexion Hippocampus-cingulum posterior

  day 0

Study Arms (1)

elderly subjects retired from agriculture

Other: Neuroimaging

Interventions

Neuroimaging OTHER

Three successive MRI acquisitions to measure FA, MTR and T2 parameters.

elderly subjects retired from agriculture

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

population retired from agricultural profession and living in rural area in Gironde

You may qualify if:

• participate in the AMI cohort
• be aged 65 and older
• be retired from agricultural profession
• live in rural area in Gironde

You may not qualify if:

• contraindication of MRI
• left-handed
• severe dementia
• Parkinson's disease
• poor health incompatible with the transport to neuroimaging service
• to be left handed

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux

Bordeaux, 33076, France

Location

MeSH Terms

Conditions

Dementia; Alzheimer Disease; Disease; Cognitive Dysfunction

Interventions

Neuroimaging

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Tauopathies; Neurodegenerative Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cognition Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Neurological; Investigative Techniques

Study Officials

• Michèle ALLARD

  University Hospital, Bordeaux

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 22, 2009
• First Posted: August 4, 2009
• Study Start: April 1, 2009
• Primary Completion: March 1, 2011
• Study Completion: March 1, 2011
• Last Updated: April 30, 2012

Record last verified: 2012-04

Locations

FR (1)