Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults

NCT01264614 | Completed Results

• 1 other identifier: MIRB#00663
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate the effects of low-intensity strengthening exercise on the brain (thinking and processing speed) for patients with early dementia, compared with normative older adults. Participants will engage in 3 months of exercise 3-5 times per week using a chair and small weights. It is hypothesized that there will be a significant improvement in brain function.

Conditions

Cognitive Decline; Dementia; Alzheimer's Disease; Mild Cognitive Impairment

Keywords

exercise; neuropsychological; dementia; Alzheimer's Disease; mild cognitive impairment; strength; MCI; AD; EEG; neurophysiological; growth factor; cognitive decline; executive function

Outcome Measures

Primary Outcomes (6)

• Stroop Test Performance From Pre- to Post-intervention

  Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Lower scores on Stroop C (possible range 0-240 sec) represents better performance).

  Baseline and 3 months

• Digits Backwards Test Performance From Pre- to Post-intervention

  Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Digits backwards possible score range is 0-14 points).

  Baseline and 3 months

• Color Trails Test Performance From Pre- to Post-intervention

  Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Color Trails possible score range is 0-300 seconds).

  Baseline and 3 months

• Fuld Test Performance From Pre- to Post-intervention

  Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Fuld Semantic Recall possible score range is 0-20 points; Fuld Immediate and Delayed Recall possible score range is 0-10).

  Baseline and 3 months

• Figure Copy & Delayed Test Performance From Pre- to Post-intervention

  Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Figure Copy \& Delayed possible score range is 0-36 points).

  Baseline and 3 months

• Neurophysiological Function Pre- & Post- Intervention

  Resting EEG and ERP recordings before (T1) and after (T2) strengthening exercise intervention

  Baseline and 3 months

Study Arms (2)

Early stage dementia

EXPERIMENTAL

Individuals with early stage dementia who attended a Adult Day Care Program at least twice a week. Participants engaged in a strengthening exercise program three to five times per week for 10 weeks.

Behavioral: Strengthening exercise

Normative older adults

ACTIVE COMPARATOR

Normative older adults with no known neurological condition. Participants engaged in a strengthening exercise program three to five times per week for 10 weeks.

Behavioral: Strengthening exercise

Interventions

Strengthening exercise BEHAVIORAL

3 months of 3-5 times per week of low-intensity exercises using a chair and small weights

Also known as: Strong Bones Program

Early stage dementia; Normative older adults

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult Day Program Participants with early dementia able to consent or assent with surrogate permission
• Control participants (55-100+ yo) able to participate at location with doctor permission

You may not qualify if:

• history of significant TBI, psychiatric condition, substance abuse, physical conditions that preclude participation in cognitive testing or strengthening exercises

Sponsors & Collaborators

• Union College, New York: lead
• US Department of Veterans Affairs: collaborator

Study Sites (1)

Stratton VA Medical Center

Albany, New York, 12208, United States

Location

Related Publications (1)

• Yerokhin V, Anderson-Hanley C, Hogan MJ, Dunnam M, Huber D, Osborne S, Shulan M. Neuropsychological and neurophysiological effects of strengthening exercise for early dementia: a pilot study. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2012;19(3):380-401. doi: 10.1080/13825585.2011.628378. Epub 2011 Dec 2.

  PMID: 22136405 RESULT

MeSH Terms

Conditions

Cognitive Dysfunction; Dementia; Alzheimer Disease; Motor Activity

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Behavior

Results Point of Contact

• Title: Cay Anderson-Hanley, PhD
• Organization: UNION COLLEGE

andersoc@union.edu

518-388-6355

Study Officials

• Cay Anderson-Hanley, PhD

  Union College

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 21, 2010
• First Posted: December 22, 2010
• Study Start: December 1, 2010
• Primary Completion: April 1, 2011
• Study Completion: April 1, 2011
• Last Updated: March 11, 2015
• Results First Posted: March 11, 2015

Record last verified: 2015-03

Locations

US (1)