A Double-blind Randomized Placebo Controlled Comparison of Scopolamine With Cinnarizin for Prevention of Simulator Sickness
Sponsor study identifier
interventional
100
1 country
1
Study Start
September 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
September 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
BACKGROUND:flight simulator have become an important component in pilot training. However, they are known to be associated with motion sickness like symptoms defined as Simulator Sickness (SS). Prevention countermeasures against motion sickness have been studied extensively focusing on cholinergic blockers and antihistamines. Most comparataive studies emphasized the effectiveness of scopolamine over outher agents. Evidence, though, on prophylaxis against SS is sparse. OBJECTIVE: to assess the effectiveness of oral scopolamine versus oral cinnarizine or placebo for SS prevention in helicopter pilots. DESIGN: a prospective, placebo controlled double-blind. SETTING: Israel Air Forse (IAF) Helicopter Aircaft vWeapon System Trainer. PARTICIPANTS: IAF experienced helicopter pilots. INTERVENTION: 0.6 mg oral scopolamine or 50 mg oral cinnarizine or placebo 1 hour before beginning of a 3 sortie simulator training
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September 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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September 2009
Date type not reportedThis date has not been verified as actual or estimated.
September 2010
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September 2010
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September 8, 2010
Actual (reported)September 9, 2010
Actual (reported)Finding more effective treatment to the motion sickness symptoms during and after simulator training.
To record a significant difference in motion sickness symptoms reduction during and after simulator training, after taking cinnarizine, scopolamine or placebo. We predict that scopolamine will prove to be more effective than cinnarizine with fewer side effects that can compromise pilot's performance during training.
1 year
0.6 mg
50 mg
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base 30 IAF
Yavné, Israel
First Submitted
September 8, 2010
First Posted
September 9, 2010
Study Start
September 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2010
Estimated (date passed)Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
September 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
September 9, 2010
Record last verified: 2010-09
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