Neuromodulation in Depressed and Schizophrenic Patients - Changing MEP (Muscle Evoked Potentials) by tDCS (Transcranial Direct Current Stimulation)

NCT01150734 | Completed

• 1 other identifier: 07/2009
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Muscle evoked potentials (MEP) are supposed to different in schizophrenic and depressed patients, compared to a sample of healthy volunteers. Transcranial Magnetic Stimulation (TMS)-evoked MEP are measured in all three groups at baseline and after tDCS (2 mA, 20 minutes). MEP amplitudes are supposed to normalize quickly in healthy volunteers, to stay diminished in depressed patients and to stay elevated in schizophrenic patients. These differences should disappear after regular pharmacological treatment. Outcome measures will be done in week 2 and week 4.

Conditions

Schizophrenia; Depression

Keywords

differences of Muscle evoked potentials (MEP) in psychiatric illnesses; differences in neuromodulation; normalization of neuromodulation after pharmacological treatment

Outcome Measures

Primary Outcomes (1)

• Decreased MEP amplitudes in depressed patients

  MEP amplitudes are supposed to be lower than in healthy controls or schizophrenic patients

  at baseline

Secondary Outcomes (3)

• Elevated MEP amplitudes in schizophrenic patients

  at baseline

• Normalization of MEP amplitudes after drug treatment

  4 weeks after baseline

• Normalization of MEP amplitudes after drug treatment

  4 weeks after baseline

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

15 depressed patients 15 schizophrenic patients 15 healthy volunteers

You may qualify if:

• The patient must be in the condition to understand the patient-information, as well as the necessary examinations.
• He/she must be able to give a written consent.
• No medication at least three weeks before enrollment.

You may not qualify if:

• Existence of a care/legal incapacity
• Existing pregnancy
• Severe psychiatric illness (with exception of affective disorder)
• Acute suicidality
• Drug-, medication- or alcohol dependence
• Dementia according to DSM IV / ICD 10-criterions
• Severe brain infarctus in the anamnesis
• Indications of structural damage of the basal ganglia or the brain stem
• Severe neurological disorders (e.g. M. Parkinson, epilepsy, discus-prolapse, dementia, systemic neurological illnesses, normal pressure hydrocephalus, cerebrovascular diseases, elevated intracranial pressure, in the last 6 months, polyneuropathies).
• Severe other medical conditions, like manifest arterial hypertonia, severe heart disease, pacemakers, respiratory failure, malignant illnesses all type, also in the history, active infectious diseases, skeletal disorders (like M. Paget, osteoporosis with spontaneous fractures, fresh fractures) Other circumstances, that speaks against a participation of the patient pinion of Medical Doctor at this study.

Sponsors & Collaborators

• Ludwig-Maximilians - University of Munich: lead

Study Sites (1)

Ludwig-Maximilians-University

Munich, 80333, Germany

Location

Related Links

• Related Info

MeSH Terms

Conditions

Schizophrenia; Depression

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Study Officials

• Frank Padberg, MD

  Ludwig-Maximilian-University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 23, 2010
• First Posted: June 25, 2010
• Study Start: October 1, 2009
• Primary Completion: December 1, 2010
• Study Completion: January 1, 2011
• Last Updated: April 22, 2011

Record last verified: 2011-04

Locations

DE (1)