Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)

NCT01150019 | Completed DMC

• 1 other identifier: PET_Resistin
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.

Conditions

Atherosclerosis

Keywords

atherosclerosis; vascular inflammation; resistin; adiponectin; 18FDG-PET

Outcome Measures

Primary Outcomes (1)

• Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET

  12 weeks

Secondary Outcomes (3)

• Circulating serum adiponectin levels

  12 weeks

• carotid intima-media thickness levels measured using ultrasonography

  12 weeks

• Circulating serum resistin levels

  12 weeks

Study Arms (2)

Obese Group

Other: Cross sectional study

Non Obese Group

Other: Cross sectional study

Interventions

Cross sectional study OTHER

This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

Non Obese Group; Obese Group

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy participats who underwent a medical health check in the health promotion center in Korea Guro University

You may qualify if:

• Healthy volunteers for visiting routine medical check in our clinic

You may not qualify if:

• History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
• Diabetes
• Hypertension
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin

Sponsors & Collaborators

• Korea University: lead

Study Sites (1)

Hae Yoon Choi

Seoul, 152-703, South Korea

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma, whole blood, serum

MeSH Terms

Conditions

Atherosclerosis

Interventions

Cross-Sectional Studies

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Studies; Epidemiologic Study Characteristics; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Kyung Mook Choi, MD.PhD

  Korea University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 9, 2010
• First Posted: June 24, 2010
• Study Start: April 1, 2010
• Primary Completion: June 1, 2010
• Study Completion: June 1, 2010
• Last Updated: July 8, 2010

Record last verified: 2010-04

Locations

KR (1)