Progression of Early Subclinical Atherosclerosis

NCT01410318 | Active Not Recruiting DMC

• 1 other identifier: PESA CNIC-SANTANDER
• Study Type: observational
• Target: 4,184
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of this study is to characterize the prevalence and progression rate of subclinical atherosclerotic lesions and to study their association to the imaging characteristics of atheroma plaques and to the presence of genetic, epigenetic, metabolomic, and environmental factors, including dietary habits, physical activity, biorhythms, psychosocial characteristics, and exposure to environmental pollutants

Conditions

Atherosclerosis

Keywords

Atherosclerosis; PESA; Subclinical; Cardiovascular diseases; Coronary disease; Heart diseases; Heart Failure; Myocardial Infarction; Stroke; Arteriosclerosis

Outcome Measures

Primary Outcomes (1)

• To assess the prevalence and 6-year progression rate of subclinical atherosclerotic disease in a population aged 40-54 years using basic and advanced cardiovascular imaging techniques.

  The basic imaging tests consist of vascular 2D and 3D ultrasound in carotid, aorta and ilio-femoral arteries and computed tomography (CT) for coronary artery calcification. The advanced imaging test consist of magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose-positron emission tomography (18FDG PET) in carotid and ilio-femoral territories. These imaging techniques enable early detection of subclinical atherosclerosis, characterization of the atherosclerotic burden, and monitoring of disease progression.

  20 years

Secondary Outcomes (1)

• To assess the association of both emerging and traditional cardiovascular risk factors with progression of subclinical atherosclerotic disease.

  20 years

Other Outcomes (2)

• To characterize the composition and evolution of atherosclerotic lesions using MRI and 18FDG PET to determine their relationship to risk factors and genetic, epigenetic, metabolomic, and environmental factors.

  20 years

• To assess the prevalence and progression of subclinical atherosclerosis in perimenopausal women and its relationship to cardiovascular risk factors and hormonal changes.

  20 years

Eligibility Criteria

• Age: 40 Years - 54 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The target population of the study consists of employees (N= 4,184) of the Banco de Santander Group in the Madrid region (65% males and 35% females, aged 40-54 years).

You may qualify if:

• Employees of the Banco de Santander Group
• Age between 40-54 years.

You may not qualify if:

• Myocardial Infarction
• Angina pectoris
• Stroke, either transient or with sequelae
• Peripheral vascular disease
• Prior angioplasty or heart surgery
• Atrial fibrillation
• Other heart diseases
• Subjects with the following conditions will also be excluded:
• Pregnancy
• Active treatment for any cancer
• Morbid obesity (BMI ≥40)
• Renal failure with creatinine clearance \<60 mL/min, as estimated by the Cockcroft and Gault formula
• Any disease that decreases life expectation to ≤6 years
• Pacemaker, implantable automatic defibrillator, or any implanted device that contraindicates MRI
• A chest CT in the previous year

Sponsors & Collaborators

• Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III: lead
• Grupo Santander: collaborator

Study Sites (1)

Ciudad Financiera del Grupo Santander

Boadilla del Monte, Madrid, 28660, Spain

Location

Related Publications (32)

• Fernandez-Ortiz A, Jimenez-Borreguero LJ, Penalvo JL, Ordovas JM, Mocoroa A, Fernandez-Friera L, Laclaustra M, Garcia L, Molina J, Mendiguren JM, Lopez-Melgar B, de Vega VM, Alonso-Farto JC, Guallar E, Sillesen H, Rudd JH, Fayad ZA, Ibanez B, Sanz G, Fuster V. The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: rationale and design. Am Heart J. 2013 Dec;166(6):990-8. doi: 10.1016/j.ahj.2013.08.024. Epub 2013 Oct 10.

  PMID: 24268213 BACKGROUND

• Fernandez-Friera L, Ibanez B, Fuster V. Imaging subclinical atherosclerosis: is it ready for prime time? A review. J Cardiovasc Transl Res. 2014 Oct;7(7):623-34. doi: 10.1007/s12265-014-9582-4. Epub 2014 Aug 14.

  PMID: 25119855 BACKGROUND

• Fernandez-Friera L, Penalvo JL, Fernandez-Ortiz A, Ibanez B, Lopez-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martinez de Vega V, Garcia L, Molina J, Sanchez-Gonzalez J, Guzman G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovas JM, Sanz G, Jimenez-Borreguero LJ, Fuster V. Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study. Circulation. 2015 Jun 16;131(24):2104-13. doi: 10.1161/CIRCULATIONAHA.114.014310. Epub 2015 Apr 16.

  PMID: 25882487 RESULT

• Fernandez-Alvira JM, Fuster V, Dorado B, Soberon N, Flores I, Gallardo M, Pocock S, Blasco MA, Andres V. Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study. J Am Coll Cardiol. 2016 May 31;67(21):2467-76. doi: 10.1016/j.jacc.2016.03.530.

  PMID: 27230041 RESULT

• Lopez-Melgar B, Fernandez-Friera L, Sanchez-Gonzalez J, Vilchez JP, Cecconi A, Mateo J, Penalvo JL, Oliva B, Garcia-Ruiz JM, Kauffman S, Jimenez-Borreguero LJ, Ruiz-Cabello J, Fernandez-Ortiz A, Ibanez B, Fuster V. Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method. Atherosclerosis. 2016 May;248:230-7. doi: 10.1016/j.atherosclerosis.2016.03.002. Epub 2016 Mar 15.

  PMID: 27038420 RESULT

• Penalvo JL, Fernandez-Friera L, Lopez-Melgar B, Uzhova I, Oliva B, Fernandez-Alvira JM, Laclaustra M, Pocock S, Mocoroa A, Mendiguren JM, Sanz G, Guallar E, Bansilal S, Vedanthan R, Jimenez-Borreguero LJ, Ibanez B, Ordovas JM, Fernandez-Ortiz A, Bueno H, Fuster V. Association Between a Social-Business Eating Pattern and Early Asymptomatic Atherosclerosis. J Am Coll Cardiol. 2016 Aug 23;68(8):805-14. doi: 10.1016/j.jacc.2016.05.080.

  PMID: 27539172 RESULT

• Hurtado-Roca Y, Bueno H, Fernandez-Ortiz A, Ordovas JM, Ibanez B, Fuster V, Rodriguez-Artalejo F, Laclaustra M. Oxidized LDL Is Associated With Metabolic Syndrome Traits Independently of Central Obesity and Insulin Resistance. Diabetes. 2017 Feb;66(2):474-482. doi: 10.2337/db16-0933. Epub 2016 Dec 19.

  PMID: 27993926 RESULT

• Coffeng JK, van der Ploeg HP, Castellano JM, Fernandez-Alvira JM, Ibanez B, Garcia-Lunar I, van der Beek AJ, Fernandez-Ortiz A, Mocoroa A, Garcia-Leal L, Cardenas E, Rojas C, Martinez-Castro MI, Santiago-Sacristan S, Fernandez-Gallardo M, Mendiguren JM, Bansilal S, van Mechelen W, Fuster V. A 30-month worksite-based lifestyle program to promote cardiovascular health in middle-aged bank employees: Design of the TANSNIP-PESA randomized controlled trial. Am Heart J. 2017 Feb;184:121-132. doi: 10.1016/j.ahj.2016.11.002. Epub 2016 Nov 10.

  PMID: 28224926 RESULT

• Lopez-Melgar B, Fernandez-Friera L, Oliva B, Garcia-Ruiz JM, Penalvo JL, Gomez-Talavera S, Sanchez-Gonzalez J, Mendiguren JM, Ibanez B, Fernandez-Ortiz A, Sanz J, Fuster V. Subclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life: The PESA Study. J Am Coll Cardiol. 2017 Jul 18;70(3):301-313. doi: 10.1016/j.jacc.2017.05.033.

  PMID: 28705310 RESULT

• Uzhova I, Fuster V, Fernandez-Ortiz A, Ordovas JM, Sanz J, Fernandez-Friera L, Lopez-Melgar B, Mendiguren JM, Ibanez B, Bueno H, Penalvo JL. The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study. J Am Coll Cardiol. 2017 Oct 10;70(15):1833-1842. doi: 10.1016/j.jacc.2017.08.027.

  PMID: 28982495 RESULT

• Fernandez-Alvira JM, Fuster V, Pocock S, Sanz J, Fernandez-Friera L, Laclaustra M, Fernandez-Jimenez R, Mendiguren J, Fernandez-Ortiz A, Ibanez B, Bueno H. Predicting Subclinical Atherosclerosis in Low-Risk Individuals: Ideal Cardiovascular Health Score and Fuster-BEWAT Score. J Am Coll Cardiol. 2017 Nov 14;70(20):2463-2473. doi: 10.1016/j.jacc.2017.09.032.

  PMID: 29145946 RESULT

• Fernandez-Friera L, Fuster V, Lopez-Melgar B, Oliva B, Garcia-Ruiz JM, Mendiguren J, Bueno H, Pocock S, Ibanez B, Fernandez-Ortiz A, Sanz J. Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors. J Am Coll Cardiol. 2017 Dec 19;70(24):2979-2991. doi: 10.1016/j.jacc.2017.10.024.

  PMID: 29241485 RESULT

• Dominguez F, Fuster V, Fernandez-Alvira JM, Fernandez-Friera L, Lopez-Melgar B, Blanco-Rojo R, Fernandez-Ortiz A, Garcia-Pavia P, Sanz J, Mendiguren JM, Ibanez B, Bueno H, Lara-Pezzi E, Ordovas JM. Association of Sleep Duration and Quality With Subclinical Atherosclerosis. J Am Coll Cardiol. 2019 Jan 22;73(2):134-144. doi: 10.1016/j.jacc.2018.10.060.

  PMID: 30654884 RESULT

• Tsilingiri K, de la Fuente H, Relano M, Sanchez-Diaz R, Rodriguez C, Crespo J, Sanchez-Cabo F, Dopazo A, Alonso-Lebrero JL, Vara A, Vazquez J, Casasnovas JM, Alfonso F, Ibanez B, Fuster V, Martinez-Gonzalez J, Martin P, Sanchez-Madrid F. Oxidized Low-Density Lipoprotein Receptor in Lymphocytes Prevents Atherosclerosis and Predicts Subclinical Disease. Circulation. 2019 Jan 8;139(2):243-255. doi: 10.1161/CIRCULATIONAHA.118.034326.

  PMID: 30586697 RESULT

• Fernandez-Friera L, Fuster V, Lopez-Melgar B, Oliva B, Sanchez-Gonzalez J, Macias A, Perez-Asenjo B, Zamudio D, Alonso-Farto JC, Espana S, Mendiguren J, Bueno H, Garcia-Ruiz JM, Ibanez B, Fernandez-Ortiz A, Sanz J. Vascular Inflammation in Subclinical Atherosclerosis Detected by Hybrid PET/MRI. J Am Coll Cardiol. 2019 Apr 2;73(12):1371-1382. doi: 10.1016/j.jacc.2018.12.075.

  PMID: 30922468 RESULT

• Redondo-Bravo L, Fernandez-Alvira JM, Gorriz J, Mendiguren JM, Sanz J, Fernandez-Friera L, Garcia-Ruiz JM, Fernandez-Ortiz A, Ibanez B, Bueno H, Fuster V. Does Socioeconomic Status Influence the Risk of Subclinical Atherosclerosis?: A Mediation Model. J Am Coll Cardiol. 2019 Jul 30;74(4):526-535. doi: 10.1016/j.jacc.2019.05.042.

  PMID: 31345427 RESULT

• Yin X, Willinger CM, Keefe J, Liu J, Fernandez-Ortiz A, Ibanez B, Penalvo J, Adourian A, Chen G, Corella D, Pamplona R, Portero-Otin M, Jove M, Courchesne P, van Duijn CM, Fuster V, Ordovas JM, Demirkan A, Larson MG, Levy D. Lipidomic profiling identifies signatures of metabolic risk. EBioMedicine. 2020 Jan;51:102520. doi: 10.1016/j.ebiom.2019.10.046. Epub 2019 Dec 24.

  PMID: 31877415 RESULT

• de la Chica JA, Gomez-Talavera S, Garcia-Ruiz JM, Garcia-Lunar I, Oliva B, Fernandez-Alvira JM, Lopez-Melgar B, Sanchez-Gonzalez J, de la Pompa JL, Mendiguren JM, Martinez de Vega V, Fernandez-Ortiz A, Sanz J, Fernandez-Friera L, Ibanez B, Fuster V. Association Between Left Ventricular Noncompaction and Vigorous Physical Activity. J Am Coll Cardiol. 2020 Oct 13;76(15):1723-1733. doi: 10.1016/j.jacc.2020.08.030.

  PMID: 33032733 RESULT

• Sanchez-Cabo F, Rossello X, Fuster V, Benito F, Manzano JP, Silla JC, Fernandez-Alvira JM, Oliva B, Fernandez-Friera L, Lopez-Melgar B, Mendiguren JM, Sanz J, Ordovas JM, Andres V, Fernandez-Ortiz A, Bueno H, Ibanez B, Garcia-Ruiz JM, Lara-Pezzi E. Machine Learning Improves Cardiovascular Risk Definition for Young, Asymptomatic Individuals. J Am Coll Cardiol. 2020 Oct 6;76(14):1674-1685. doi: 10.1016/j.jacc.2020.08.017.

  PMID: 33004133 RESULT

• Rossello X, Fuster V, Oliva B, Sanz J, Fernandez Friera LA, Lopez-Melgar B, Mendiguren JM, Lara-Pezzi E, Bueno H, Fernandez-Ortiz A, Ibanez B, Ordovas JM. Association Between Body Size Phenotypes and Subclinical Atherosclerosis. J Clin Endocrinol Metab. 2020 Dec 1;105(12):3734-44. doi: 10.1210/clinem/dgaa620.

  PMID: 32879953 RESULT

• Martinez-Lopez D, Roldan-Montero R, Garcia-Marques F, Nunez E, Jorge I, Camafeita E, Minguez P, Rodriguez de Cordoba S, Lopez-Melgar B, Lara-Pezzi E, Fernandez-Ortiz A, Ibanez B, Valdivielso JM, Fuster V, Michel JB, Blanco-Colio LM, Vazquez J, Martin-Ventura JL. Complement C5 Protein as a Marker of Subclinical Atherosclerosis. J Am Coll Cardiol. 2020 Apr 28;75(16):1926-1941. doi: 10.1016/j.jacc.2020.02.058.

  PMID: 32327104 RESULT

• Lopez-Melgar B, Fernandez-Friera L, Oliva B, Garcia-Ruiz JM, Sanchez-Cabo F, Bueno H, Mendiguren JM, Lara-Pezzi E, Andres V, Ibanez B, Fernandez-Ortiz A, Sanz J, Fuster V. Short-Term Progression of Multiterritorial Subclinical Atherosclerosis. J Am Coll Cardiol. 2020 Apr 14;75(14):1617-1627. doi: 10.1016/j.jacc.2020.02.026.

  PMID: 32273027 RESULT

• Cortes-Canteli M, Gispert JD, Salvado G, Toribio-Fernandez R, Tristao-Pereira C, Falcon C, Oliva B, Mendiguren J, Fernandez-Friera L, Sanz J, Garcia-Ruiz JM, Fernandez-Ortiz A, Sanchez-Gonzalez J, Ibanez B, Molinuevo JL, Fuster V. Subclinical Atherosclerosis and Brain Metabolism in Middle-Aged Individuals: The PESA Study. J Am Coll Cardiol. 2021 Feb 23;77(7):888-898. doi: 10.1016/j.jacc.2020.12.027.

  PMID: 33602472 RESULT

• Tristao-Pereira C, Fuster V, Lopez-Jimenez A, Fernandez-Pena A, Semerano A, Fernandez-Nueda I, Garcia-Lunar I, Ayuso C, Sanchez-Gonzalez J, Ibanez B, Gispert JD, Cortes-Canteli M. Subclinical atherosclerosis and brain health in midlife: Rationale and design of the PESA-Brain study. Am Heart J. 2024 Dec;278:195-207. doi: 10.1016/j.ahj.2024.09.028. Epub 2024 Sep 24.

  PMID: 39322173 DERIVED

• Devesa A, Fuster V, Garcia-Lunar I, Oliva B, Garcia-Alvarez A, Moreno-Arciniegas A, Vazirani R, Perez-Herreras C, Marina P, Bueno H, Fernandez-Friera L, Fernandez-Ortiz A, Sanchez-Gonzalez J, Ibanez B. Coronary Microvascular Function in Asymptomatic Middle-Aged Individuals With Cardiometabolic Risk Factors. JACC Cardiovasc Imaging. 2025 Jan;18(1):48-58. doi: 10.1016/j.jcmg.2024.08.002. Epub 2024 Sep 11.

  PMID: 39269413 DERIVED

• Fernandez-Friera L, Garcia-Alvarez A, Oliva B, Garcia-Lunar I, Garcia I, Moreno-Arciniegas A, Gomez-Talavera S, Perez-Herreras C, Sanchez-Gonzalez J, de Vega VM, Rossello X, Bueno H, Fernandez-Ortiz A, Ibanez B, Sanz J, Fuster V. Association between subclinical atherosclerosis burden and unrecognized myocardial infarction detected by cardiac magnetic resonance in middle-aged low-risk adults. Eur Heart J Cardiovasc Imaging. 2024 Jun 28;25(7):968-975. doi: 10.1093/ehjci/jeae044.

  PMID: 38426763 DERIVED

• Toribio-Fernandez R, Tristao-Pereira C, Carlos Silla-Castro J, Callejas S, Oliva B, Fernandez-Nueda I, Garcia-Lunar I, Perez-Herreras C, Maria Ordovas J, Martin P, Blanco-Kelly F, Ayuso C, Lara-Pezzi E, Fernandez-Ortiz A, Garcia-Alvarez A, Dopazo A, Sanchez-Cabo F, Ibanez B, Cortes-Canteli M, Fuster V. Apolipoprotein E-epsilon2 and Resistance to Atherosclerosis in Midlife: The PESA Observational Study. Circ Res. 2024 Feb 16;134(4):411-424. doi: 10.1161/CIRCRESAHA.123.323921. Epub 2024 Jan 23.

  PMID: 38258600 DERIVED

• Mendieta G, Pocock S, Mass V, Moreno A, Owen R, Garcia-Lunar I, Lopez-Melgar B, Fuster JJ, Andres V, Perez-Herreras C, Bueno H, Fernandez-Ortiz A, Sanchez-Gonzalez J, Garcia-Alvarez A, Ibanez B, Fuster V. Determinants of Progression and Regression of Subclinical Atherosclerosis Over 6 Years. J Am Coll Cardiol. 2023 Nov 28;82(22):2069-2083. doi: 10.1016/j.jacc.2023.09.814.

  PMID: 37993199 DERIVED

• Tristao-Pereira C, Fuster V, Oliva B, Moreno-Arciniegas A, Garcia-Lunar I, Perez-Herreras C, Scholl M, Suarez-Calvet M, Moro MA, Garcia-Alvarez A, Fernandez-Ortiz A, Sanchez-Gonzalez J, Zetterberg H, Blennow K, Ibanez B, Gispert JD, Cortes-Canteli M. Longitudinal interplay between subclinical atherosclerosis, cardiovascular risk factors, and cerebral glucose metabolism in midlife: results from the PESA prospective cohort study. Lancet Healthy Longev. 2023 Sep;4(9):e487-e498. doi: 10.1016/S2666-7568(23)00134-4.

  PMID: 37659430 DERIVED

• Sanchez-Cabo F, Fuster V, Silla-Castro JC, Gonzalez G, Lorenzo-Vivas E, Alvarez R, Callejas S, Benguria A, Gil E, Nunez E, Oliva B, Mendiguren JM, Cortes-Canteli M, Bueno H, Andres V, Ordovas JM, Fernandez-Friera L, Quesada AJ, Garcia JM, Rossello X, Vazquez J, Dopazo A, Fernandez-Ortiz A, Ibanez B, Fuster JJ, Lara-Pezzi E. Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study. Eur Heart J. 2023 Aug 1;44(29):2698-2709. doi: 10.1093/eurheartj/ehad361.

  PMID: 37339167 DERIVED

• Devesa A, Lobo-Gonzalez M, Martinez-Milla J, Oliva B, Garcia-Lunar I, Mastrangelo A, Espana S, Sanz J, Mendiguren JM, Bueno H, Fuster JJ, Andres V, Fernandez-Ortiz A, Sancho D, Fernandez-Friera L, Sanchez-Gonzalez J, Rossello X, Ibanez B, Fuster V. Bone marrow activation in response to metabolic syndrome and early atherosclerosis. Eur Heart J. 2022 May 14;43(19):1809-1828. doi: 10.1093/eurheartj/ehac102. Epub 2022 Mar 11.

  PMID: 35567559 DERIVED

• Raposeiras-Roubin S, Rossello X, Oliva B, Fernandez-Friera L, Mendiguren JM, Andres V, Bueno H, Sanz J, Martinez de Vega V, Abu-Assi E, Iniguez A, Fernandez-Ortiz A, Ibanez B, Fuster V. Triglycerides and Residual Atherosclerotic Risk. J Am Coll Cardiol. 2021 Jun 22;77(24):3031-3041. doi: 10.1016/j.jacc.2021.04.059.

  PMID: 34140107 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

* Orine (4 x 5 mL) * Blood (8 x 0.6 mL) * Serum (8 x 0.6 mL) * EDTA plasma (8 x 0.6 mL) * Buffy Coat (2 x 0.6 mL) * Non insultated RNA (2 x 5 mL PAXgene) * Insulated DNA (2 x 0.3 mL, 150 ng/microL + 1 x 0.3 mL, 75 ng/microL)

MeSH Terms

Conditions

Atherosclerosis; Cardiovascular Diseases; Coronary Disease; Heart Diseases; Heart Failure; Myocardial Infarction; Stroke; Arteriosclerosis

Condition Hierarchy (Ancestors)

Arterial Occlusive Diseases; Vascular Diseases; Myocardial Ischemia; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Valentín Fuster, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  PRINCIPAL INVESTIGATOR

• Antonio I Fernández Ortiz, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY DIRECTOR

• Borja Ibañez, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

• Ginés Sanz, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

• Jose María Ordovás, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

• Luis Jesús Jiménez Borreguero, MD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

• Jose Luis Peñalvo, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

• Martín Laclaustra, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

• Ana Dopazo, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

• Leticia Fernández Friera, PhD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

• Agustin Mocoroa, MD

  Banco Santander

  STUDY CHAIR

• Beatriz Lopez Melgar, MD

  Centro Nacional de Investigaciones Cardiovasculares Carlos III

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 2, 2011
• First Posted: August 5, 2011
• Study Start: June 14, 2010
• Primary Completion (Estimated): June 1, 2030
• Study Completion (Estimated): June 1, 2030
• Last Updated: April 29, 2021

Record last verified: 2021-04

Locations

ES (1)