NCT01143376

Brief Summary

The most appropriate and effective exercise interventions for weight loss remain a matter of continued discussion and there is a need to identify sustainable exercise programs which successfully promote weight loss and benefit health. The primary objective of this study is to determine if high-intensity intermittent sprinting (HIIS) produces better results in terms of reducing metabolic and cardiovascular risk factors, with special emphasis to fat mass loss and insulin sensitivity in "healthy" obese volunteers compared with an iso-caloric program of moderate-intensity continuous cycling (MICC) (control condition following the international recommendations). We will also assess the impact of short duration sprints (SDS) in the above factors and to understand the potential mechanisms behind different outcomes among training programs. The overall hypothesis is that HIIS will lead to a greater reduction in metabolic and cardiovascular risk factors compared with MICC in healthy obese volunteers and that SDS will produce similar improvements in cardiovascular risk factors as the longer duration HIIS

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
46

participants targeted

Target at P25-P50 for not_applicable obesity

Timeline
Completed

Started May 2010

Typical duration for not_applicable obesity

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2010

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

June 2, 2010

Completed
12 days until next milestone

First Posted

Study publicly available on registry

June 14, 2010

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2012

Completed
1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2014

Completed
Last Updated

April 20, 2017

Status Verified

April 1, 2017

Enrollment Period

2.6 years

First QC Date

June 2, 2010

Last Update Submit

April 19, 2017

Conditions

Obesity

Keywords

Obesityexercisebody compositioninsulin sensitivityappetitefood intake

Outcome Measures

Primary Outcomes (1)

  • Changes in body composition

    Body composition assessed by DEXA

    Baseline and after 12 weeks of training

Secondary Outcomes (1)

  • Changes in insulin sensitivity

    Baseline and after 12 weeks of training

Study Arms (3)

Moderate intensity exercise

ACTIVE COMPARATOR

Moderate intensity exercise

Behavioral: Moderate intensity exercise

High Intensity training

EXPERIMENTAL

High Intensity intermittent training

Behavioral: High intensity training

Short springs

EXPERIMENTAL

short springs training

Behavioral: short springs

Interventions

High intensity trainingBEHAVIORAL

high-intensity intermittent sprinting (HIIS) (8 sec sprint:12 sec rest) for 12 weeks, 4 times a week

High Intensity training
short springsBEHAVIORAL

short duration sprints (SDS)(8 sec sprint:12 sec rest) for 12 weeks, 4 times a week

Short springs
Moderate intensity exerciseBEHAVIORAL
Moderate intensity exercise

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • weight stable on the last three months,
  • not currently dieting to lose weight
  • inactive lifestyle.

You may not qualify if:

  • History of endocrine/cardiovascular/pulmonary/kidney disease,
  • anaemia,
  • gout,
  • depression or other psychological disorders,
  • eating disorders,
  • drug or alcohol abuse within the last two years
  • current medication known to affect appetite or induce weight loss.
  • planned surgery during the study period
  • participation in another research study
  • restraint score derived from the TFEQ\>12
  • post-menopausal women

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Norwegian University of Science and Technology

Trondheim, 7489, Norway

Location

Related Publications (2)

  • Martins C, Kazakova I, Ludviksen M, Mehus I, Wisloff U, Kulseng B, Morgan L, King N. High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals. Int J Sport Nutr Exerc Metab. 2016 Jun;26(3):197-204. doi: 10.1123/ijsnem.2015-0078. Epub 2015 Oct 19.

    PMID: 26479856RESULT

  • Martins C, Aschehoug I, Ludviksen M, Holst J, Finlayson G, Wisloff U, Morgan L, King N, Kulseng B. High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese. Med Sci Sports Exerc. 2017 Sep;49(9):1851-1858. doi: 10.1249/MSS.0000000000001296.

    PMID: 28398946RESULT

MeSH Terms

Conditions

ObesityMotor ActivityInsulin Resistance

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehaviorHyperinsulinismGlucose Metabolism DisordersMetabolic Diseases

Intervention Hierarchy (Ancestors)

Physical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Catia Martins, PhD

    Norwegian University of Science and Technology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 2, 2010

First Posted

June 14, 2010

Study Start

May 1, 2010

Primary Completion

December 1, 2012

Study Completion

January 1, 2014

Last Updated

April 20, 2017

Record last verified: 2017-04

Locations

NO(1)