NCT00773214

Brief Summary

The identification and characterization of individuals who vary in their response to exercise-induced weight loss is important. Weight loss in response to exercise is variable and it remains unknown who will succeed, why, and more importantly how to improve weight loss efficacy. This study will examine changes in behavioural, metabolic, physiological and biochemical variables in response to a 12 week supervised exercise programme and evaluate their association with weight loss in overweight and obese sedentary individuals. Our hypothesis is that changes in the plasma levels of appetite related hormones undermine the inter individual variation in weight loss in response to exercise. This study will improve the understanding of variability to exercise-induced weight loss and allow more individually tailored and appropriate strategies for weight management programmes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
22

participants targeted

Target at below P25 for not_applicable obesity

Timeline
Completed

Started Apr 2008

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2008

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

October 15, 2008

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 16, 2008

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2009

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2009

Completed
Last Updated

February 6, 2015

Status Verified

February 1, 2015

Enrollment Period

10 months

First QC Date

October 15, 2008

Last Update Submit

February 5, 2015

Conditions

Obesity

Keywords

ObesityAppetiteBody compositionEnergy compensation

Outcome Measures

Primary Outcomes (1)

  • Changes in fasting and postprandial plasma levels of appetite related hormones

    Baseline and after a 12 week exercise intervention

Secondary Outcomes (1)

  • Changes in body weight and body composition

    Baseline and after a 12-week exercise intervention

Study Arms (1)

exercise

EXPERIMENTAL
Behavioral: Exercise

Interventions

ExerciseBEHAVIORAL

12-week supervised exercise programme (5 times /week at 75% maximal Heart Rate)

exercise

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • \<BMI\<35 Kg/m2
  • weight stable on the last three months (\<2kg)
  • not currently dieting to lose weight
  • with an inactive lifestyle (not engaged in strenuous work or in regular brisk leisure time exercise more than once a week or in light exercise for more than 20 minutes/day in more than 3 times/week)

You may not qualify if:

  • History of endocrine/cardiovascular/pulmonary/kidney disease, anaemia, gout, depression or other psychological disorders
  • Eating disorders
  • Drug or alcohol abuse within the last two years
  • Current medication known to affect appetite or induce weight loss.
  • Those with a planned surgery during the study period or participating in another research study will also not be accepted to take part in this study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Norwegian University of Science and Technology

Trondheim, 7030, Norway

Location

Related Publications (1)

  • Martins C, Kulseng B, King NA, Holst JJ, Blundell JE. The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. J Clin Endocrinol Metab. 2010 Apr;95(4):1609-16. doi: 10.1210/jc.2009-2082. Epub 2010 Feb 11.

    PMID: 20150577RESULT

MeSH Terms

Conditions

Obesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Catia Martins, BSc, MSc, PhD

    Norwegian University of Science and Technology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 15, 2008

First Posted

October 16, 2008

Study Start

April 1, 2008

Primary Completion

February 1, 2009

Study Completion

December 1, 2009

Last Updated

February 6, 2015

Record last verified: 2015-02

Locations

NO(1)