NCT01143363

Brief Summary

Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals. Changes in the appetite-regulatory system in response to exercise are likely to explain, at least partially, the better outcome observed after HIIS. Unfortunately, there are no studies comparing the impact of different types of acute aerobic exercise on the release of appetite-regulating hormones, subjective feelings of appetite and subsequent energy intake (EI). The primary objective of this study is to investigate the effects of acute isocaloric bouts of HIIT and MICC or a short duration sprint, in comparison with a resting control condition, on the postprandial release of appetite-regulating hormones, subjective feelings of appetite and subsequent EI in obese individuals. The investigators hypothesize that an isocaloric session of HIIS will result in a better short-term appetite control compared with MICC, by reducing hunger feelings and subsequent food intake more than MICC and by inducing a larger increase in the release of satiety gut peptides compared with the MICC.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable obesity

Timeline
Completed

Started May 2010

Longer than P75 for not_applicable obesity

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2010

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

June 2, 2010

Completed
12 days until next milestone

First Posted

Study publicly available on registry

June 14, 2010

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2012

Completed
1.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2014

Completed
Last Updated

February 6, 2015

Status Verified

February 1, 2015

Enrollment Period

2.6 years

First QC Date

June 2, 2010

Last Update Submit

February 5, 2015

Conditions

Obesity

Keywords

Obesityexerciseappetitehungersatietyfood intake

Outcome Measures

Primary Outcomes (1)

  • Changes in gut peptides

    Blood samples taken in fasting and postprandially for 3h

Secondary Outcomes (1)

  • Food intake at test meal

    3h after breakfast

Study Arms (4)

Resting - control

PLACEBO COMPARATOR

No exercise

Behavioral: resting - control

Moderate intensity exercise

EXPERIMENTAL

Moderate intensity exercise (continuous) 1h after breakfast

Behavioral: Moderate intensity exercise

High intensity intermittent training

EXPERIMENTAL

High intensity intermittent training 1h after breakfast

Behavioral: High intensity intermittent training

Short sprint

EXPERIMENTAL

Short sprint 1h after breakfast

Behavioral: Short sprint

Interventions

resting - controlBEHAVIORAL
Resting - control
Moderate intensity exerciseBEHAVIORAL
Moderate intensity exercise
High intensity intermittent trainingBEHAVIORAL
High intensity intermittent training
Short sprintBEHAVIORAL
Short sprint

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • an inactive lifestyle,
  • weight stable on the previous 3 months,
  • not currently dieting to loose weight
  • restraint score derived from the Three Factor Eating Behaviour Questionnaire ≤12

You may not qualify if:

  • history of coronary heart disease,
  • type 1 or type 2 diabetes,
  • anaemia,
  • gout,
  • depression or other psychological disorders,
  • eating disorders,
  • drug or alcohol abuse within the last two years,
  • current medication known to affect appetite or induce weight loss and hypertension.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Norwegian University of Science and Technology

Trondheim, 7489, Norway

Location

Related Publications (1)

  • Martins C, Stensvold D, Finlayson G, Holst J, Wisloff U, Kulseng B, Morgan L, King NA. Effect of moderate- and high-intensity acute exercise on appetite in obese individuals. Med Sci Sports Exerc. 2015 Jan;47(1):40-8. doi: 10.1249/MSS.0000000000000372.

    PMID: 24824772RESULT

MeSH Terms

Conditions

ObesityMotor Activity

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehavior

Study Officials

  • Catia Martins, PhD

    Norwegian University of Science and Technology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 2, 2010

First Posted

June 14, 2010

Study Start

May 1, 2010

Primary Completion

December 1, 2012

Study Completion

June 1, 2014

Last Updated

February 6, 2015

Record last verified: 2015-02

Locations

NO(1)