Preventing Childhood Obesity: A Two-pronged Approach Starting in Pregnancy and the First Year Postpartum

NCT01129505 | Completed

• 1 other identifier: OPG-92367
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Our longitudinal aim is to reduce childhood obesity using our two-pronged intervention program, which includes healthy food choices and increased physical activity initiated during pregnancy and re-instated in the early period after delivery for overweight and obese women. We will accomplish this with our family-based Nutrition and Exercise Lifestyle Intervention Program (NELIP) to promote healthy family living. An intervention targeting school-aged children on the importance of healthy lifestyles occurs too late to prevent childhood obesity and establish lifelong healthy body weights. To break this spiraling cycle of generations of unhealthy body weights in Canadian children, and to reduce the risk of future obesity-related health problems, it is necessary to prevent excessive pregnancy weight gain, high blood sugars in the mother and to promote a healthy lifestyle during pregnancy and early post delivery. With our NELIP team as a cornerstone, and our pilot data already collected with promising results, we foresee an opportunity over the next 3 years to contribute to changing patient care with emphasis on disease prevention and healthy family lifestyle initiation early in life to reverse the trend of childhood obesity. With a solid research-based initiative from the lab to the community by educating health care providers, future health care can be improved by putting prevention-based programs into practice. Healthy women = healthy babies = healthy families = healthy futures!!

Conditions

Childhood Obesity; Excessive Weight Gain in Pregnancy With Baby Delivered; Dietary Modification; Healthy Lifestyle Habits

Keywords

pregnancy; intervention; exercise; nutrition; infants

Outcome Measures

Primary Outcomes (1)

• To prevent excessive pregnancy weight gain and GDM to decrease incidence of macrosomia

  To prevent excessive pregnancy weight gain on NELIP and GDM in order to decrease the incidence of macrosomia and large for gestational age babies (\> 4.0 kg)

  weekly weight gain during pregnancy and birth

Secondary Outcomes (1)

• To prevent weight retention in the mother and encourage healthy infant feeding practices

  2, 6 and 12 months post delivery

Interventions

Nutrition & Exercise Lifestyle Intervention Program (NELIP) BEHAVIORAL

Nutrition- individualize total energy intake with a minimum of 2000 kcal/day with a restriction of not more than 33% total energy intake, total carbohydrate of 40-50% total energy intake, total fat intake of 30% of total energy intake (substituting monounsaturated fatty acids for saturated and trans-fatty acids), and approximately 30% dedicated to protein intake. Exercise-25 minutes of walking per session, 3-4 times per week, each subsequent week increasing by 2 mins to a maximum of 40 mins/session. Family-based Behavioural Treatment (FBBT) Coupled with the individualized NELIP for each woman, FBBT will be presented in 3 group sessions (including family members), focussing on strategies to make healthy lifestyle choices with behavioural strategies.

Also known as: NELIP, FBBT

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• medically pre-screened for contraindications to exercise
• prior to 16 weeks gestation (pregnancy program)
• singleton pregnancy and pre-pregnancy BMI equal or greater than 25
• before 2 months post delivery (postpartum program)
• BMI equal or greater than 25 (postpartum program)

You may not qualify if:

• diagnosed with gestational diabetes or type 2 diabetes

Sponsors & Collaborators

• Western University, Canada: lead
• Canadian Institutes of Health Research (CIHR): collaborator
• Health Research Foundation: collaborator

Study Sites (1)

Exercise and Pregnancy Lab, 2245, 3-M Centre - University of Western Ontario

London, Ontario, N6A 3K7, Canada

Location

Related Publications (2)

• Mottola MF, Giroux I, Gratton R, Hammond JA, Hanley A, Harris S, McManus R, Davenport MH, Sopper MM. Nutrition and exercise prevent excess weight gain in overweight pregnant women. Med Sci Sports Exerc. 2010 Feb;42(2):265-72. doi: 10.1249/MSS.0b013e3181b5419a.

  PMID: 20083959 RESULT

• Hubbard ME, Ruchat SM, Davenport MH, Prapavessis H, Gratton R, McManus R, Giroux I, Hanley AJ, Mottola MF. Impact of an Antenatal Family-based Behavioral Treatment with a Nutrition and Exercise Lifestyle Intervention Program on Infant Weight-for-length at Birth. Int J Behav Med. 2025 Jan 6. doi: 10.1007/s12529-024-10345-8. Online ahead of print.

  PMID: 39762494 DERIVED

Related Links

• Click for more information about this study.

MeSH Terms

Conditions

Pediatric Obesity; Motor Activity

Interventions

Nutritional Status

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Health Status; Demography; Population Characteristics

Study Officials

• Michelle F Mottola, PhD

  Western University, Canada

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Michelle F. Mottola, FACSM

Study Record Dates

• First Submitted: May 21, 2010
• First Posted: May 24, 2010
• Study Start: March 1, 2009
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2013
• Last Updated: December 11, 2023

Record last verified: 2023-12

Locations

CA (1)