Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.

NCT01883674 | Completed

• 1 other identifier: PLC-021742
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

This project evaluates the use of different types of proteins from various food sources after an exercise session, on muscle mass and physical capacity in aged sarcopenic men (who have low muscle mass). Specifically, researchers want to:

• Examine the efficiency of protein intake after exercise on muscle mass and physical abilities;
• Examine the impact of exercise and proteins on blood lipids (LDL cholesterol, HDL cholesterol, total cholesterol and triglycerides);
• Examine the impact of exercise and proteins on liver enzymes;
• Examine the impact of exercise and proteins on a hormone that controls hunger;
• Evaluate the program's impact on the ability of the body to produce energy. All participants are exercising (resistance training) and ingest one of the 3 different sources of proteins, immediately after training:
• Milk proteins (from milk beverage)
• Essential amino acids (added to a soya beverage)
• No protein (rice beverage - control group) Our hypothesis is that proteins from milk will induce a gain in muscle mass and physical function equivalent to the essential amino acids (EAA). We anticipate that both milk proteins and EAA will be both superior to control group. This would represent an interesting finding since milk is more accessible, palatable and cheaper than essential amino acids commercial mix.

Conditions

Sarcopenia

Keywords

Sarcopenia; Physical capacity; Muscle force; Muscle quality; Milk proteins; Essential amino acids; Proteins; Resistance training; Exercise

Outcome Measures

Primary Outcomes (1)

• Muscle mass

  At baseline and post intervention (17th week)

Secondary Outcomes (6)

• Relative strength

  At baseline and post intervention (17th week)

• Blood markers of inflammation

  At baseline and post intervention (17th week)

• Plasma Lipid profile

  At baseline and post intervention (17th week)

• Plasma creatinine

  At baseline, mid (8th week) and post intervention (17th week)

• Blood markers of fatty liver

  At baseline and post intervention (17th week)

Other Outcomes (2)

• Dietary intakes

  At baseline, mid (8th week) and post intervention (17th week)

• Physical activity level

  At baseline and post intervention (17th week)

Study Arms (3)

Milk proteins

EXPERIMENTAL

This group will do a resistance training + milk proteins (milk beverage)

Other: Resistance training

Essential amino acids (add to soya bvg)

EXPERIMENTAL

This group will do a resistance training + essential amino acids (added to soya beverage)

Other: Resistance training

No protein (control)

PLACEBO COMPARATOR

This group will do a resistance training + ingestion of the control beverage (no protein, rice beverage)

Other: Resistance training

Interventions

Resistance training OTHER

All group will exercise 3x/week. Each session of resistance training will last 60min. and will target main muscular groups.

Essential amino acids (add to soya bvg); Milk proteins; No protein (control)

Eligibility Criteria

• Age: 65 Years - 75 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• years
• francophone or understanding French
• muscle mass index \< 10.75 kg/m2 (Janssen et al, 2004)
• body mass index \<30kg/m²
• weight stable (\< 2 kg) for 6 mo
• no resistance exercise for 3 years
• controlled blood pressure for at least 6 months

You may not qualify if:

• major physical disability
• medical treatment influencing metabolism
• statin treatment
• diagnosis or any sign of kidney disease

Sponsors & Collaborators

• Université de Sherbrooke: lead
• Dairy Farmers of Canada: collaborator

Study Sites (1)

Centre de recherche sur le vieillissement

Sherbrooke, Quebec, J1H 4C4, Canada

Location

MeSH Terms

Conditions

Sarcopenia; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Isabelle J. Dionne, Ph.D.

  Université de Sherbrooke

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 7, 2013
• First Posted: June 21, 2013
• Study Start: May 1, 2012
• Primary Completion: April 1, 2014
• Study Completion: December 1, 2014
• Last Updated: December 3, 2014

Record last verified: 2014-12

Locations

CA (1)