NCT01038102|Completed
Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance
HEPFAT
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HEPFAT
Sponsor study identifier
Secondary identifiers
OTHER_GRANT · Center for clinical research Dalarna 2009
interventional
65
1 country
1
Study Start
February 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
April 2010
Actual (reported)Study Completion
April 2010
Actual (reported)The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2010
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2009
Date type not reportedThis date has not been verified as actual or estimated.
December 21, 2009
Actual (reported)December 23, 2009
Actual (reported)April 2010
Actual (reported)April 2010
Actual (reported)Hepatic steatosis by MRT
10 weeks
Insulin resistance by oral glucose tolerance test
10 weeks
Changes in adipose tissue gene expression and lipogenic enzyme activity
10 weeks
Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%)
Diet high in saturated fat (15 E%)
Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%).
Diet high in saturated fat (15E%)
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Uppsala University Hospital, Uppsala Science Park
Uppsala, 75185, Sweden
Summers LK, Fielding BA, Bradshaw HA, Ilic V, Beysen C, Clark ML, Moore NR, Frayn KN. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. Diabetologia. 2002 Mar;45(3):369-77. doi: 10.1007/s00125-001-0768-3.
Yki-Jarvinen H. Fat in the liver and insulin resistance. Ann Med. 2005;37(5):347-56. doi: 10.1080/07853890510037383.
Ulf Risérus, PhD
Clinical Nutrition and Metabolism, Dept. of Public Health and Caring Sciences, Uppsala University
65 participants (actual enrollment reported by the registry).
First Submitted
December 21, 2009
First Posted
December 23, 2009
Study Start
February 2009
Date type not reportedThis date has not been verified as actual or estimated.
Relation of Obesity With Frequency of Meals (MST 0557)
Contact the study team to confirm eligibility.
Bjermo H, Iggman D, Kullberg J, Dahlman I, Johansson L, Persson L, Berglund J, Pulkki K, Basu S, Uusitupa M, Rudling M, Arner P, Cederholm T, Ahlstrom H, Riserus U. Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial. Am J Clin Nutr. 2012 May;95(5):1003-12. doi: 10.3945/ajcn.111.030114. Epub 2012 Apr 4.
Primary Completion
April 2010
Actual (reported)Study Completion
April 2010
Actual (reported)Last Updated
July 13, 2010
Record last verified: 2009-12
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Source: ClinicalTrials.gov.
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