NCT00229255|Completed
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Sponsor study identifier
interventional
22
1 country
1
Study Start
March 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2009
Actual (reported)Study Completion
June 2009
Actual (reported)The purpose of this study is to test the relationship between frequency of meals and hepatic fat content and insulin sensitivity. We, the researchers at Rockefeller University, hypothesize that low plasma insulin levels (as achieved by periods of fasting) will prevent insulin resistance and reduce hepatic lipid content. In contrast, frequent, carbohydrate-rich meals will predispose to hepatic steatosis (non-alcoholic) and insulin resistance. This is a 6 week inpatient study.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2009
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2005
Date type not reportedThis date has not been verified as actual or estimated.
September 27, 2005
Actual (reported)September 29, 2005
Actual (reported)June 2009
Actual (reported)June 2009
Actual (reported)We will determine total body insulin sensitivity with the help of the hyperinsulinemic-euglycemic clamp. We will also assess hepatic steatosis by conducting MRI scans on our subjects.
days 8,9,11 41 and 42
Weight, waist and hip circumference, fasting glucose and insulin, serum ketones, lipids and lipoproteins including VLDL and apolipoprotien B100, liver function tests, serum adiponectin (marker for insulin resistance), and measures of hunger.
days 1-42
High carbohydrate diet i.e. 65% carbohydrate, 15% protein, 20% fat for 4 weeks.
high carbohydrate diet i.e. 65% carbohydrate, 15% protein, 20% fat for 4 weeks
high carbohydrate diet i.e. 65% carbohydrate, 15% protein, 20% fat for 4 weeks.
high carbohydrate diet i.e. 65% carbohydrate, 15% protein, 20% fat for 4 weeks.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Rockefeller University Hospital
New York, New York, 10021, United States
Markus Stoffel, MD, PHD
Rockefeller University
22 participants (actual enrollment reported by the registry).
First Submitted
September 27, 2005
First Posted
September 29, 2005
Study Start
March 2005
Date type not reportedThis date has not been verified as actual or estimated.
Chromium's Effect on Insulin Resistance in Obesity
Contact the study team to confirm eligibility.
Primary Completion
June 2009
Actual (reported)Study Completion
June 2009
Actual (reported)Last Updated
June 1, 2012
Record last verified: 2012-05
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Source: ClinicalTrials.gov.
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