Bluebird
Effect of Varying Dose and Molecular Weight on the Serum LDL-cholesterol-lowering Properties of Oat β-glucan
Sponsor study identifier
interventional
367
3 countries
5
Study Start
November 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 2009
Actual (reported)Study Completion
August 2009
Actual (reported)The purposes of this study were:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2009
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2008
Date type not reportedThis date has not been verified as actual or estimated.
July 2009
Actual (reported)August 2009
Actual (reported)September 18, 2009
Actual (reported)September 22, 2009
Actual (reported)Serum LDL-cholesterol lowering effect of 3g high MW beta-glucan
4 weeks
Correlation between serum LDL-cholesterol lowering and log(MW*C)
4 weeks
Total cholesterol
4 weeks
Serum triglycerides
4 weeks
Serum HDL cholesterol
4 weeks
Fasting serum glucose
4 weeks
Serum aspartate transaminase
4 weeks
Wheat bran cereal
Cereal containing 3g high molecular weight oat beta glucan
Cereal containing 4g oat beta glucan with medium molecular weight
21g per day of ready to eat breakfast cereal containing wheat bran with 8g of total dietary fiber and 0.5g beta-glucan.
20.2 grams per day of ready to eat cereal containing 6g total dietary fiber and 3g oat beta glucan with high molecular weight
SUGiRS Human Nutrition Unit, School of Molecular & Microbial Biosciences, Unviersity of Sydney
Sydney, New South Wales, 2006, Australia
Human Nutraceutical Research Unit, Department of Human Health and Nutritional Sciences, University of Guelph
Guelph, Ontario, N1G 2W1, Canada
Glycemic Index Laboratories, Inc.
Toronto, Ontario, M5C 2X3, Canada
Nutraceuticals and Functional Foods Institute, Faculte des science de l'agriculture et de l'alimentation, Universite Laval
Laval, Quebec, Canada
Reading Scientific Services, Ltd (RSSL)
Reading, Berkshire, RG6 6LA, United Kingdom
Wolever TM, Tosh SM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Thomson BA, Duss R, Wood PJ. Physicochemical properties of oat beta-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am J Clin Nutr. 2010 Oct;92(4):723-32. doi: 10.3945/ajcn.2010.29174. Epub 2010 Jul 21.
Tosh SM, Brummer Y, Miller SS, Regand A, Defelice C, Duss R, Wolever TM, Wood PJ. Processing affects the physicochemical properties of beta-glucan in oat bran cereal. J Agric Food Chem. 2010 Jul 14;58(13):7723-30. doi: 10.1021/jf904553u.
Thomas MS Wolever, MD, PhD
Glycemic Index Laboratories, Inc
Peter J Wood, PhD
Agriculture and Agri-Food Canada
Susan M Tosh, PhD
Agriculture and Agri-Food Canada
Alison L Gibbs, PhD
Department of Statistics, University of Toronto
367 participants (actual enrollment reported by the registry).
First Submitted
September 18, 2009
First Posted
September 22, 2009
Study Start
November 2008
Date type not reportedThis date has not been verified as actual or estimated.
Efficacy and Safety of HEP-40 Chitosan for Mild to Moderately Elevated Cholesterol
Cereal containing 3g oat beta glucan with medium molecular weight
Cereal containing 4g oat beta glucan with low molecular weight
28.5g ready to eat cereal containing 8g total dietary fiber and 4g oat beta glucan with medium molecular weight
21.1g of ready to eat cereal containing 6g total fiber and 3g oat beta glucan with a medium molecular weight
28.7g ready to eat cereal containing 8g total dietary fiber and 4g oat beta glucan with low molecular weight
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Wolever TM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Tosh SM, Duss R. Bioactive oat beta-glucan reduces LDL cholesterol in Caucasians and non-Caucasians. Nutr J. 2011 Nov 25;10:130. doi: 10.1186/1475-2891-10-130.
Primary Completion
July 2009
Actual (reported)Study Completion
August 2009
Actual (reported)Last Updated
June 21, 2011
Record last verified: 2011-06
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Source: ClinicalTrials.gov.
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