Stress Resilience Study

NCT00891488 | Completed

• 2 other identifiers: AG01191R03AG030551-01A1
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test the hypothesis that physiological adaptations to regular exercise training (i.e. physical fitness) attenuates age-related decline in stress resilience to both oxidative stress and the neuroendocrine responses to psychosocial stress.

Conditions

Oxidative Stress; Aging

Keywords

VO2 max; stress; cortisol; fitness

Outcome Measures

Primary Outcomes (2)

• F2-isoprostane response to an oxidative challenge (forearm ischemia-reperfusion trial)

  Visit 4

• Cortisol response (plasma and salivary) to a psychosocial laboratory stressor--Trier Social Stress Test (TSST)

  Visit 3

Secondary Outcomes (3)

• Total antioxidant capacity

  Visit 4

• ACTH response to TSST

  Visit 3

• Heart rate response to the TSST

  Visit 3

Study Arms (2)

Fit

Unfit

Eligibility Criteria

• Age: 60 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community sample

You may qualify if:

• Men and post-menopausal women, ages 60-80 years
• Generally good health by self-report

You may not qualify if:

• Estrogen or testosterone supplementation within the previous 6 months
• Current smoker
• Body Mass Index (BMI) \> 32 kg/m2
• Any chronic illness that could affect cortisol levels, including diabetes mellitus, liver or renal disease
• Evidence of a previous myocardial infarction within the last 6 months by EKG or history of angina or shortness of breath
• Clinically significant arrhythmia on a resting EKG or significant EKG changes during the baseline VO2max test
• Any other condition that would contraindicate maximal exercise testing, including elevated blood pressure at rest (systolic BP \>140 or diastolic BP \>90 mm Hg on at least 2 measurements, at least 10 minutes apart) or musculoskeletal problems
• Depression as measured by the Beck Depression Inventory (BDI score \>17)
• Use of anti-oxidant supplements, in excess of standard multi-vitamins (1 tablet/day)

Sponsors & Collaborators

• Kronos Longevity Research Institute: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

Kronos Longevity Research Institute

Phoenix, Arizona, 85016, United States

Location

Related Publications (4)

• Traustadottir T, Bosch PR, Matt KS. The HPA axis response to stress in women: effects of aging and fitness. Psychoneuroendocrinology. 2005 May;30(4):392-402. doi: 10.1016/j.psyneuen.2004.11.002. Epub 2005 Jan 11.

  PMID: 15694119 BACKGROUND

• Fatouros IG, Jamurtas AZ, Villiotou V, Pouliopoulou S, Fotinakis P, Taxildaris K, Deliconstantinos G. Oxidative stress responses in older men during endurance training and detraining. Med Sci Sports Exerc. 2004 Dec;36(12):2065-72. doi: 10.1249/01.mss.0000147632.17450.ff.

  PMID: 15570141 BACKGROUND

• Vincent HK, Bourguignon C, Vincent KR. Resistance training lowers exercise-induced oxidative stress and homocysteine levels in overweight and obese older adults. Obesity (Silver Spring). 2006 Nov;14(11):1921-30. doi: 10.1038/oby.2006.224.

  PMID: 17135607 BACKGROUND

• Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000 Nov 9;408(6809):239-47. doi: 10.1038/35041687.

  PMID: 11089981 BACKGROUND

Related Links

• Kronos Longevity Research Institute

Biospecimen

Retention: SAMPLES WITH DNA

Blood, saliva, and urine samples

Study Officials

• Tinna Traustadóttir, PhD

  Kronos Longevity Research Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 30, 2009
• First Posted: May 1, 2009
• Study Start: July 1, 2008
• Primary Completion: May 1, 2010
• Study Completion: May 1, 2010
• Last Updated: August 3, 2010

Record last verified: 2010-07

Locations

US (1)