Human Brain Antioxidants During Oxidative Stress
Noninvasive Antioxidant Quantification in the Human Brain Under Oxidative Stress
2 other identifiers
observational
52
1 country
1
Brief Summary
Antioxidants are important for having a good memory and for smart thinking when people get old, and that is important for everyone's quality of life. This research will find out if normal aging and Alzheimer's disease use up brain antioxidants. It will develop a new imaging tool that can help doctors to stop cognitive decline.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jun 2013
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 22, 2012
CompletedFirst Posted
Study publicly available on registry
October 25, 2012
CompletedStudy Start
First participant enrolled
June 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
July 24, 2018
CompletedMay 3, 2019
May 1, 2019
4 years
October 22, 2012
May 1, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Antioxidant in Alzheimers
Occipital cortex and posterior cingulate ascorbate and glutathione concentration in young and elder patients as well as in patients with AD
1 year
Study Arms (1)
Elderly control
Healthy elderly subjects age and gender matched to the AD cohort, predominantly male
Eligibility Criteria
All data have been accrued for the healthy aging aim, which included healthy people age 18-22 and age 70-89. To study the second aim, 23 patients with AD will be recruited from the Minneapolis, MN VA medical center. 23 age - and gender- matched controls will be recruited to study neurodegenerative disease associated demand on the antioxidant system. We do NOT currently have the resources to screen candidates with AD who are not current patients at the VA medical center in Minneapolis.
You may qualify if:
- Age and gender match to AD patients: age range 65-89:
- note that we anticipate that our patients will be predominantly male, so we are NOT likely to enroll females for this portion of the study
You may not qualify if:
- Claustrophobia Implanted metal devices Pregnancy \> RDA dietary supplements
- ≥ 5 F+V per day Smoking Depression Poor health or systemic illness Medial history of or evidence for cognitive problems Unstable medication usage Neurological problems Psychiatric disorder Substance abuse Usage of investigational drugs Inability to complete cognitive tests written in and calibrated for English speakers Inadequate vision or hearing to accommodate participation MMSE (dementia) score ≤ 26
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Minnesotalead
- National Institute on Aging (NIA)collaborator
Study Sites (1)
University of Minnesota
Minneapolis, Minnesota, 55455, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Melissa Terpstra, PhD
University of Minnesota
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 22, 2012
First Posted
October 25, 2012
Study Start
June 1, 2013
Primary Completion
June 1, 2017
Study Completion
July 24, 2018
Last Updated
May 3, 2019
Record last verified: 2019-05