Relationship Between Physical Activity and Stem Cells in Older Adults

NCT00690183 | Completed

• 1 other identifier: 0226-08-EP
• Study Type: observational
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

This is a pilot study to develop a collaborative, translational research project investigating whether physical activity may in part exert a positive influence on aging via the mobilization of stem cells. Preliminary data will be collected to explore the relationship between physical activity and stem cell populations found in the blood. The study hypothesis is that stem cell decrease with age, but that persons who are more physically active will have a higher number of stem cells in the blood. The first assessment will include an evaluation of health, physical activity and lifestyle via questionnaires. Height, weight and abdominal girth will be measured, and blood will be drawn for immune and stem cell assessment. Participants will be given a pedometer and accelerometer to wear daily for 7 days. Participants will return for a second visit at which the pedometer and accelerometer will be returned and blood will be drawn. Stem cell and immune assays will be repeated to evaluate the variability of these measures over time. The correlation between stem cell numbers and physical activity will be analyzed.

Conditions

Aging

Keywords

physical activity; stem cells; lifestyle

Outcome Measures

Primary Outcomes (2)

• circulating stem cells

  Number of circulating stem cells determined by lab

  upon enrollment, one week later

• physical activity

  physical activity as reported

  upon enrollment

Secondary Outcomes (3)

• alcohol consumption

  upon enrollment

• smoking history

  upon enrollment

• plasma cytokine levels

  upon enrollment, one later

Eligibility Criteria

• Age: 60 Years - 105 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community Sample of Omaha, NE metro area

You may qualify if:

• years of age or older

You may not qualify if:

• Hospitalization within 2 months prior
• Immunological disease
• Hematopoietic disease
• No current infection
• No current chemotherapy

Sponsors & Collaborators

• University of Nebraska: lead

Study Sites (1)

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma will be retained for cytokine analysis.

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Laura D Bilek, PhD, PT

  University of Nebraska

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 2, 2008
• First Posted: June 4, 2008
• Study Start: June 5, 2008
• Primary Completion: August 1, 2008
• Study Completion: October 1, 2008
• Last Updated: September 28, 2023

Record last verified: 2023-09

Locations

US (1)