Mindfulness Meditation in Older Adults

NCT01532596 | Completed Early Phase 1

• 1 other identifier: MBSR-Older-00001
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test if an 8-week mindfulness meditation training (vs a wait-list control condition) program reduces neurobehavioral reactivity and improves affect regulation in a sample of older adults, as measured by functional magnetic resonance imaging. Additionally, we will examine if mindfulness meditation training reduces loneliness and markers of chronic inflammation.

Conditions

Aging

Outcome Measures

Primary Outcomes (1)

• Functional Neural Activity

  Neural responses to emotionally evocative stimuli

  Change from Baseline to 2 months

Secondary Outcomes (3)

• Pro-inflammation

  Change from Baseline to 2 months

• Loneliness

  Change from Baseline to 2 months

• Psychological Distress

  Change from Baseline to 2 months

Study Arms (2)

Mindfulness-Based Stress Reduction

EXPERIMENTAL

A standardized 8-week mindfulness meditation training program

Behavioral: Mindfulness-Based Stress Reduction

Wait-List

NO INTERVENTION

Interventions

Mindfulness-Based Stress Reduction BEHAVIORAL

8-week standardized mindfulness meditation training program

Also known as: MBSR

Mindfulness-Based Stress Reduction

Eligibility Criteria

• Age: 55 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• English-speaking adults between the ages of 55-85 years of age at time of entry
• post-menopausal and not pregnant (women only)
• Accessible geographically and willing to come to UCLA for all study related activities

You may not qualify if:

• they have regularly (\>1 time per week) practiced a mind-body therapy anytime in the last six months (e.g., meditation, yoga, tai chi)
• are not ambulatory, (c) indicate any treatment for mental health problems in the last six months
• indicate any major physical health problems in the last three months
• use medications affecting cardiovascular or endocrine function
• are left-handed
• or have metal in their bodies (including pacemakers and permanent piercings (e.g., bellyrings), but not dental fillings)
• indicate regular use of psychotropic medication or psychotherapy in the last six months
• cognitive impairment as indicated by a score lower than 23 on the Mini-Mental State examination
• smokers
• indicate feeling claustrophobic in confined spaces, such as an fMRI scanner
• weigh over 300 lbs
• indicate any use of doctor prescribed cholesterol lowering medications (e.g., statins)
• use any doctor prescribed pain medication
• indicate any implants

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

Cousins Center for Psychoneuroimmunology, UCLA

Los Angeles, California, 90095, United States

Location

MeSH Terms

Interventions

Mindfulness-Based Stress Reduction

Intervention Hierarchy (Ancestors)

Mindfulness; Cognitive Behavioral Therapy; Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• J. David Creswell, Ph.D.

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post-Doctoral Fellow, Cousins Center for Psychoneuroimmunology

Study Record Dates

• First Submitted: February 8, 2012
• First Posted: February 14, 2012
• Study Start: January 1, 2008
• Primary Completion: January 1, 2009
• Study Completion: January 1, 2009
• Last Updated: February 14, 2012

Record last verified: 2012-02

Locations

US (1)