Co-existent Obstructive Sleep Apnea (OSA) and Obesity: Finding Non-exercise Activity Thermogenesis (NEAT) Targets for Intervention
Co-existent OSA and Obesity: Finding NEAT Targets for Intervention
1 other identifier
observational
9
1 country
1
Brief Summary
Rationale: Obesity is an increasing childhood epidemic in Canada. Obstructive sleep apnea (OSA) is a complication of obesity which causes cardiovascular disease, reduced quality of life, and premature death. While the complex interactions between obesity and OSA are not entirely clear, we hypothesize that these conditions may compound each other by:
- 1.decreasing physical activity and total energy expenditure by reducing both non-exercise physical pursuits (NEAT- non-exercise activity thermogenesis) and purposeful physical activity.
- 2.alterations in the secretion of appetite-controlling hormones, which may lead to increases in energy intake.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Sep 2010
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 2, 2009
CompletedFirst Posted
Study publicly available on registry
March 3, 2009
CompletedStudy Start
First participant enrolled
September 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedMarch 9, 2018
March 1, 2018
2 years
March 2, 2009
March 7, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
NEAT (kcal/day)
10 day period
Secondary Outcomes (1)
Physical activity behavior (minutes of moderate-vigorous physical activity as directly measured by accelerometry), appetite regulating hormone profile and self-report appetite assessment.
10 day period
Study Arms (2)
1.
Children with both obesity and obstructive sleep apnea
2
Children without the presence of both obesity and obstructive sleep apnea
Eligibility Criteria
Subjects will be recruited from those scheduled to undergo polysomnography in the sleep laboratory at the Children's Hospital of Eastern Ontario
You may qualify if:
- age 10-17 years
- coming for polysomnography at the Children's Hospital of Eastern Ontario
You may not qualify if:
- children receiving treatment for OSA with CPAP (continuous positive airway pressure) or bi-level therapy
- craniofacial abnormalities
- genetic syndromes
- neuromuscular disease
- tracheostomy
- medications that may affect appetite or energy balance (systemic corticosteroids)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Childrens Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1, Canada
Biospecimen
urine
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- INDIV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Katz, Sherri Lynne, M.D.
Study Record Dates
First Submitted
March 2, 2009
First Posted
March 3, 2009
Study Start
September 1, 2010
Primary Completion
September 1, 2012
Study Completion
December 1, 2012
Last Updated
March 9, 2018
Record last verified: 2018-03