NCT00502398

Brief Summary

Patients with hemolytic disorders (e.g. sickle cell anemia or thalassemia) are known to develop pulmonary hypertension. Hemolysis is where red blood cells are destroyed and their contents released into the circulation. It is thought that these red-cell contents cause constriction and thrombosis of the blood vessels in the lungs. Conversely, it is possible that patients with pulmonary hypertension have hemolysis. In this study we will be drawing blood from a range of patients and normal controls for a panel of blood tests related to hemolysis.

Trial Health

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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 15, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 17, 2007

Completed
2 months until next milestone

Study Start

First participant enrolled

September 1, 2007

Completed
Last Updated

October 16, 2007

Status Verified

October 1, 2007

First QC Date

July 15, 2007

Last Update Submit

October 14, 2007

Conditions

Pulmonary Artery Hypertension

Interventions

Blood testPROCEDURE

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • One of the following four conditions :
  • Pulmonary artery hypertension
  • Obstructive sleep apnea with pulmonary hypertension
  • Lung transplant candidates without pulmonary hypertension
  • Normal Controls

You may not qualify if:

  • Known hemolytic disorder
  • Recent blood loss (\<3 months)
  • Recent blood transfusion (\<3 months)
  • Liver disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Pulmonary Institute, Rabin Medical Center (Beilinson campus)

Petah Tikva, 49100, Israel

RECRUITING

MeSH Terms

Conditions

Familial Primary Pulmonary Hypertension

Interventions

Hematologic Tests

Condition Hierarchy (Ancestors)

Hypertension, PulmonaryLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Clinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisInvestigative Techniques

Study Officials

  • Mordechai Kramer, MD

    Rabin Medical Center

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ben Fox, MRCP

CONTACT

+972 3 937 7221foxb@clalit.org.il

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 15, 2007

First Posted

July 17, 2007

Study Start

September 1, 2007

Last Updated

October 16, 2007

Record last verified: 2007-10

Locations

IL(1)