Evaluation of Respiratory Muscle in Patient With Pulmonary Arterial Hypertension

NCT05056532 | Completed

• 1 other identifier: PAH
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is that evaluation of basic and accessory respiratory muscles and their relationship of six minute walk test in patient with pulmonary arterial hypertension (PAH)

Conditions

Pulmonary Artery Hypertension

Keywords

respiratory muscle strength; exercise capacity; dyspnea; accessory respiratory muscle

Outcome Measures

Primary Outcomes (4)

• pectoralis muscle strength

  pectoralis muscle strength will be evaluated with hand held dynamometers according to muscle test technique

  15 minute

• serratus anterior muscle strength

  Serratus anterior muscle strength will be evaluated with hand held dynamometers according to muscle test technique

  15 minutes

• sternocleidomasteoideus muscle strength

  sternocleidomasteoideus muscle strength will be evaluated with hand held dynamometers according to muscle test technique

  15 minutes

• Respiratory mouth pressure

  Respiratory mouth pressure will be measured to determine maximally inspiratory pressure and maximally expiratory pressure according to ATS/ERS guidelines.

  15 minutes

Secondary Outcomes (2)

• Six Minute Walk Test (6MWT)

  30 minutes

• Dyspnea assessment

  20 minutes

Study Arms (2)

patients

Maximal mouth pressure will be evaluated for determine respiratory muscle strength, m. pectoralis, m. serratus anterior, m. sternocloideumasteoideus and quadriceps muscles strengths will be measured to evaluate accessory respiratory muscle strength, London chest activity of daily living scale will be done for assessment of dyspnea and six minute walk test will be used for determination of functionally capacity

Diagnostic Test: patient assessment

Control group

Maximal mouth pressure will be evaluated for determine respiratory muscle strength, m. pectoralis, m. serratus anterior, m. sternocloideumasteoideus and quadriceps muscles strengths will be measured to evaluate accessory respiratory muscle strength, London chest activity of daily living scale will be done for assessment of dyspnea and six minute walk test will be used for determination of functionally capacity

Diagnostic Test: patient assessment

Interventions

patient assessment DIAGNOSTIC_TEST

subjective and objective measurement will be performed in patients with PAH

Control group; patients

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

patient group will be chosen among the admitted to clinic control group will consist of invited volunteers

You may qualify if:

• patients with diagnosis of pulmonary arterial hypertension
• patients with stabil drug therapy at least three months

You may not qualify if:

• patients with obstructive and/ or restrictive lung disease comorbidity
• severe orthopedic and/ or neurological comorbidity
• patients with heart failure
• patients with ischemic heart disease
• uncooperative patients

Sponsors & Collaborators

• Giresun University: lead

Study Sites (1)

Istanbul university-cerrahpasa cardiology institute

Istanbul, Haseki, 34096, Turkey (Türkiye)

Location

Related Publications (2)

• Panagiotou M, Peacock AJ, Johnson MK. Respiratory and limb muscle dysfunction in pulmonary arterial hypertension: a role for exercise training? Pulm Circ. 2015 Sep;5(3):424-34. doi: 10.1086/682431.

  PMID: 26401245 BACKGROUND

• Riou M, Pizzimenti M, Enache I, Charloux A, Canuet M, Andres E, Talha S, Meyer A, Geny B. Skeletal and Respiratory Muscle Dysfunctions in Pulmonary Arterial Hypertension. J Clin Med. 2020 Feb 3;9(2):410. doi: 10.3390/jcm9020410.

  PMID: 32028638 BACKGROUND

MeSH Terms

Conditions

Familial Primary Pulmonary Hypertension; Dyspnea

Condition Hierarchy (Ancestors)

Hypertension, Pulmonary; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Habibe DURDU

  Giresun University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 20, 2021
• First Posted: September 24, 2021
• Study Start: September 9, 2021
• Primary Completion: March 28, 2022
• Study Completion: April 18, 2022
• Last Updated: June 1, 2022

Record last verified: 2022-05

Locations

TU (1)