A Comparison of p53-induced Genes Activation in Patients With and Without Acute Myocardial Infarction
1 other identifier
observational
79
1 country
1
Brief Summary
The purpose of this study is to compare p53-induced genes activation as possible markers differentiating between patients presenting with acute myocardial infarction and controls.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Nov 2010
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 8, 2010
CompletedFirst Posted
Study publicly available on registry
August 31, 2010
CompletedStudy Start
First participant enrolled
November 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2011
CompletedOctober 31, 2012
October 1, 2012
11 months
August 8, 2010
October 30, 2012
Conditions
Outcome Measures
Primary Outcomes (1)
Expression of P53 induced genes in patients with and without acute myocardial infarction
Up to 4 hours following recruitment
Secondary Outcomes (1)
Correlation between P53 associated gene expression with troponin level
After 5 days from recruitment
Study Arms (2)
acute MI group
Patients presenting with acute ST elevation myocardial infarction, admitted to the intensive cardiac care unit and that are planned for emergency primary PCI
Controls
Patients undergoing a non-invasive evaluation of possible myocardial ischemia.
Interventions
Eligibility Criteria
Aacute MI group- Patients with acute ST elevation MI planned for emergency primary PCI Controls: Patients undergoing non-invasive evaluation of possible myocardial ischemia
You may qualify if:
- Acute MI group:
- Patient presenting with chest pain lasting for at leasY 1 hour and no more than 6 hours accompanied by 1 of the following ECG criteria:
- ST segment elevation of anterior or inferior wall (at least 2 consecutive leads)
- New LBBB
- Controls:
- Patients undergoing non-invasive evaluation of possible myocardial ischemia
You may not qualify if:
- Chronic lung disease requiring chronic treatment
- Any malignancy in the 5 year prior to enrollment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Meir Medical Center
Kfar Saba, Israel, Israel
Related Publications (1)
Ashur-Fabian O, Avivi A, Trakhtenbrot L, Adamsky K, Cohen M, Kajakaro G, Joel A, Amariglio N, Nevo E, Rechavi G. Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12236-41. doi: 10.1073/pnas.0404998101. Epub 2004 Aug 9.
PMID: 15302922BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 8, 2010
First Posted
August 31, 2010
Study Start
November 1, 2010
Primary Completion
October 1, 2011
Study Completion
October 1, 2011
Last Updated
October 31, 2012
Record last verified: 2012-10