Screening for Fabry Disease Among Young Stroke Patients in an Israeli Stroke Clinic
1 other identifier
interventional
1,000
1 country
1
Brief Summary
The purpose of this study is to determine the incidence of Fabry Disease in young stroke patients in an Israeli stroke clinic.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 22, 2010
CompletedFirst Posted
Study publicly available on registry
April 23, 2010
CompletedStudy Start
First participant enrolled
May 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedJune 12, 2014
June 1, 2014
4.6 years
April 22, 2010
June 11, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
positive screening of fabry disease
past 5 years
Interventions
Dry blood spots (DBS) analysis of a- galactosidase-A activity will be used for male patients' diagnosis. Males and females with enzymatic activity bellow the test's cut-off will be further diagnosed by gene sequencing. Since females are heterozygote and may have high residual levels of active enzyme, female patients with a- galactosidase-A activity of 30% bellow averaged normal range will also be further diagnosed by gene sequencing as described before (8).
Eligibility Criteria
You may qualify if:
- diagnosis of stoke or TIA Time period within last 5 years -
You may not qualify if:
- Known diagnosis of stroke or index event due to trauma
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Neurology Dept. Edith Wolfson Medical Center
Holon, 58100, Israel
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor Yair Lampl
Study Record Dates
First Submitted
April 22, 2010
First Posted
April 23, 2010
Study Start
May 1, 2010
Primary Completion
December 1, 2014
Last Updated
June 12, 2014
Record last verified: 2014-06