NCT01581086

Brief Summary

This study is looking for high blood pressure in the lungs (Pulmonary artery hypertension PAH) in HIV and COPD patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jan 2012

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

April 17, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

April 19, 2012

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2016

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2017

Completed
Last Updated

August 26, 2025

Status Verified

May 1, 2016

Enrollment Period

4.3 years

First QC Date

April 17, 2012

Last Update Submit

August 19, 2025

Conditions

Pulmonary Artery Hypertension

Keywords

HIVCOPDPulmonary disease

Outcome Measures

Primary Outcomes (1)

  • elevated NT-proBNP as a biomarker

    establish a pulmonary hypertension cohort for translational investigations, to determine the utility of NT-proBNP as a biomarker of PAH

    3 years

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Pitt mens Study(MACS). University of Pittsburgh HIV Clinic(PACT). Emphysema COPD Research Center Research Registry(ECRC). University of Pittsburgh Medical center pulmonary hypertension clinic

You may qualify if:

  • Male/Female 18-80 years of age.
  • Subject has been previously enrolled in PACT/MAC/ECRC study.
  • Must have recent ProBNP test \>120pg/ml or abnormal echocardiogram (right ventricular systolic pressure \>or=40mmHg) without evidence of left sided heart failure.

You may not qualify if:

  • Previous diagnosis of congenital heart failure.
  • If evidence of Left ventricular systolic or diastolic dysfunction, echo will be reviewed by the PI on a case by case basis.
  • Creatine clearance \<60ml/min per 1.73 m2.
  • Undiagnosed chest pain or myocardial infarction, stroke or cardiovascular event within 3 months.
  • Pregnancy.
  • Subjects receiving chronic anticoagulant.
  • Inability to complete the 6 minute walk test.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Whole Blood

MeSH Terms

Conditions

Familial Primary Pulmonary HypertensionPulmonary Disease, Chronic ObstructiveLung Diseases

Condition Hierarchy (Ancestors)

Hypertension, PulmonaryRespiratory Tract DiseasesLung Diseases, ObstructiveChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Michael Risbano, MD

    University of Pittsburgh

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 17, 2012

First Posted

April 19, 2012

Study Start

January 1, 2012

Primary Completion

May 1, 2016

Study Completion

January 1, 2017

Last Updated

August 26, 2025

Record last verified: 2016-05

Locations

US(1)