NCT00473902

Brief Summary

We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (\> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
39

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Aug 2003

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2003

Completed
1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2004

Completed
2.7 years until next milestone

First Submitted

Initial submission to the registry

May 15, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 16, 2007

Completed
Last Updated

May 16, 2007

Status Verified

May 1, 2007

First QC Date

May 15, 2007

Last Update Submit

May 15, 2007

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (1)

  • a. Muscle and bone mass b. Knee extension strength e. Creatine content f. Muscle oxidative capacity g. Aerobic power (oxygen consumption)

    six months

Secondary Outcomes (1)

  • a. Functional capacity b. Strength with weight machines

    six months

Interventions

TrainingBEHAVIORAL
Creatine Monohydrate, Conjugated Linoleic AcidDRUG

Eligibility Criteria

Age65 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)

You may qualify if:

  • Healthy,
  • Ambulatory,
  • Recreationally active,
  • Community dwelling

You may not qualify if:

  • Evidence of coronary heart disease;
  • Congestive heart disease;
  • Uncontrolled hypertension;
  • Chronic obstructive pulmonary disease;
  • Diabetes mellitus;
  • Renal failure;
  • Major orthopedic disability; and
  • Smoking

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

McMaster University Medical Center

Hamilton, Ontario, L8N 3Z5, Canada

Location

Related Publications (1)

  • Tarnopolsky M, Zimmer A, Paikin J, Safdar A, Aboud A, Pearce E, Roy B, Doherty T. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS One. 2007 Oct 3;2(10):e991. doi: 10.1371/journal.pone.0000991.

    PMID: 17912368DERIVED

MeSH Terms

Conditions

Sarcopenia

Interventions

CreatineLinoleic Acids, Conjugated

Condition Hierarchy (Ancestors)

Muscular AtrophyNeuromuscular ManifestationsNeurologic ManifestationsNervous System DiseasesAtrophyPathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsSigns and Symptoms

Intervention Hierarchy (Ancestors)

GuanidinesAmidinesOrganic ChemicalsAmino AcidsAmino Acids, Peptides, and ProteinsLinoleic AcidsFatty Acids, Omega-6Fatty Acids, UnsaturatedFatty AcidsLipids

Study Officials

  • Mark A Tarnopolsky, M.D., Ph.D.

    McMaster University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 15, 2007

First Posted

May 16, 2007

Study Start

August 1, 2003

Study Completion

September 1, 2004

Last Updated

May 16, 2007

Record last verified: 2007-05

Locations

CA(1)