Exercise and Branched Chain Amino Acids (BCAA)Requirements in Older Men

NCT01931722 | Suspended DMC

• 1 other identifier: 002
• Study Type: interventional
• Target: 6
• Locations: 1 country
• Sites: 1

Brief Summary

Likely, branched chain amino acid (BCAA) requirements are increased in older strength-trained (ST) individuals. If so, supplementation in this group will maximize muscle protein synthesis (MPS) and minimize loss of muscle with age (sarcopenia).

Conditions

Sarcopenia

Keywords

branched chain amino acid requirement; older men; strength training; sarcopenia

Outcome Measures

Primary Outcomes (1)

• Required Branched chain amino acid of older strength trained men

  Branched chain amino acid requirement will be measured in 55-65 years old strength trained men using indicator amino acid oxidation method

  12 months

Secondary Outcomes (1)

• Muscle size

  12 months

Study Arms (2)

Branched chain amino acid

ACTIVE COMPARATOR

Branched chain amino acid as food supplement

Dietary Supplement: Branched chain amino acid; Behavioral: Strength training

Weight training

ACTIVE COMPARATOR

Strength training will include a split-training program using all major muscle groups of the body on a three day "on", one day "off" protocol. Muscle areas targeted on each training day will be as follows: Day1: chest, shoulder, triceps; Day2: back, biceps; Day3: legs and calfs; Day4: will be a rest day. On Day5: this cycle will begin again. A combination of free weights and machines will be used for each training day. Progressive overload protocol will be applied where the load used by every participant will be adjusted bi-weekly based on their 70% of 1RM (repetition maximum). Instruction will be provided for all exercises and professional trainers will oversee all training sessions.

Dietary Supplement: Branched chain amino acid; Behavioral: Strength training

Interventions

Branched chain amino acid DIETARY_SUPPLEMENT

seven graded intakes of a BCAA (branched chain amino acid) mixture from 50 to 350 mg.kg-1.d-1 will be used to measure BCAA requirement

Also known as: Ajinomoto branched chain amino acids

Branched chain amino acid; Weight training

Strength training BEHAVIORAL

Strength training will include a split-training program using all major muscle groups of the body on a three day "on", one day "off" protocol. Muscle areas targeted on each training day will be as follows: Day1: chest, shoulder, triceps; Day2: back, biceps; Day3: legs and calfs; Day4: will be a rest day. On Day5: this cycle will begin again. A combination of free weights and machines will be used for each training day. Progressive overload protocol will be applied where the load used by every participant will be adjusted bi-weekly based on their 70% of 1 repetition maximum (maximum weight that can be lifted only one time). Instruction will be provided for all exercises and professional trainers will oversee all training sessions.

Also known as: weight training

Branched chain amino acid; Weight training

Eligibility Criteria

• Age: 55 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Recreationally active (\~2-3 h/wk of physical activity) healthy older men (55-65 y)
• A minimum of 4 month weight training experience

You may not qualify if:

• Have symptoms or take medication for respiratory disease
• Have symptoms or take medication for cardiovascular disease
• Have symptoms or take medication for metabolic disease
• Have symptoms or take mediation for neuromuscular disease
• Use heart rate or blood pressure medications
• Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time
• Have an excessive alcohol intake (more than 2 drinks per day)
• Have any cardiovascular or neuromuscular limitations to exercise
• Are allergic to milk or milk products
• Use anabolic steroids or performance enhancing drugs

Sponsors & Collaborators

• University of Western Ontario, Canada: lead

Study Sites (1)

Exercise Nutrition Research Laboratory

London, Ontario, N6A 5B9, Canada

Location

Related Publications (15)

• Riazi R, Wykes LJ, Ball RO, Pencharz PB. The total branched-chain amino acid requirement in young healthy adult men determined by indicator amino acid oxidation by use of L-[1-13C]phenylalanine. J Nutr. 2003 May;133(5):1383-9. doi: 10.1093/jn/133.5.1383.

  PMID: 12730426 BACKGROUND

• Lemon PW, Tarnopolsky MA, MacDougall JD, Atkinson SA. Protein requirements and muscle mass/strength changes during intensive training in novice bodybuilders. J Appl Physiol (1985). 1992 Aug;73(2):767-75. doi: 10.1152/jappl.1992.73.2.767.

  PMID: 1400008 BACKGROUND

• Norton LE, Layman DK. Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise. J Nutr. 2006 Feb;136(2):533S-537S. doi: 10.1093/jn/136.2.533S.

  PMID: 16424142 BACKGROUND

• Pencharz PB, Ball RO. Different approaches to define individual amino acid requirements. Annu Rev Nutr. 2003;23:101-16. doi: 10.1146/annurev.nutr.23.011702.073247. Epub 2003 Feb 21.

  PMID: 12626690 BACKGROUND

• Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr. 2003 Aug;78(2):250-8. doi: 10.1093/ajcn/78.2.250.

  PMID: 12885705 BACKGROUND

• Lemon PW. Beyond the zone: protein needs of active individuals. J Am Coll Nutr. 2000 Oct;19(5 Suppl):513S-521S. doi: 10.1080/07315724.2000.10718974.

  PMID: 11023001 BACKGROUND

• Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr. 2006 Jan;136(1 Suppl):319S-23S. doi: 10.1093/jn/136.1.319S.

  PMID: 16365106 BACKGROUND

• Kim JS, Wilson JM, Lee SR. Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants. J Nutr Biochem. 2010 Jan;21(1):1-13. doi: 10.1016/j.jnutbio.2009.06.014. Epub 2009 Oct 1.

  PMID: 19800212 BACKGROUND

• Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E381-7. doi: 10.1152/ajpendo.00488.2005. Epub 2006 Feb 28.

  PMID: 16507602 BACKGROUND

• Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr. 2005 Nov;82(5):1065-73. doi: 10.1093/ajcn/82.5.1065.

  PMID: 16280440 BACKGROUND

• Humayun MA, Elango R, Ball RO, Pencharz PB. Reevaluation of the protein requirement in young men with the indicator amino acid oxidation technique. Am J Clin Nutr. 2007 Oct;86(4):995-1002. doi: 10.1093/ajcn/86.4.995.

  PMID: 17921376 BACKGROUND

• Dardevet D, Rieu I, Fafournoux P, Sornet C, Combaret L, Bruhat A, Mordier S, Mosoni L, Grizard J. Leucine: a key amino acid in ageing-associated sarcopenia? Nutr Res Rev. 2003 Jun;16(1):61-70. doi: 10.1079/NRR200252.

  PMID: 19079937 BACKGROUND

• Cermak NM, Res PT, de Groot LC, Saris WH, van Loon LJ. Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr. 2012 Dec;96(6):1454-64. doi: 10.3945/ajcn.112.037556. Epub 2012 Nov 7.

  PMID: 23134885 BACKGROUND

• Bross R, Ball RO, Pencharz PB. Development of a minimally invasive protocol for the determination of phenylalanine and lysine kinetics in humans during the fed state. J Nutr. 1998 Nov;128(11):1913-9. doi: 10.1093/jn/128.11.1913.

  PMID: 9808642 BACKGROUND

• Campbell WW, Trappe TA, Wolfe RR, Evans WJ. The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci. 2001 Jun;56(6):M373-80. doi: 10.1093/gerona/56.6.m373.

  PMID: 11382798 BACKGROUND

MeSH Terms

Conditions

Sarcopenia

Interventions

Amino Acids, Branched-Chain; Resistance Training

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Amino Acids; Amino Acids, Peptides, and Proteins; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Peter Lemon, PhD

  The University of Western Ontario

  PRINCIPAL INVESTIGATOR

• Arash Bandegan, MSc.

  The University of Western Ontario

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Weider Research Chair

Study Record Dates

• First Submitted: August 26, 2013
• First Posted: August 29, 2013
• Study Start: January 1, 2016
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: January 12, 2016

Record last verified: 2016-01

Locations

CA (1)