RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Darbepoetin Alfa Treatment on Mortality and Morbidity in Heart Failure (HF) Subjects With Symptomatic Left Ventricular Systolic Dysfunction and Anemia
2 other identifiers
interventional
2,278
34 countries
743
Brief Summary
The purpose of the study is to determine the efficacy of treatment of anemia with darbepoetin alfa compared to placebo on the composite of time to death from any cause or first hospital admission for worsening heart failure in patients with symptomatic left ventricular systolic dysfunction and anemia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 heart-failure
Started Jun 2006
Longer than P75 for phase_3 heart-failure
743 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2006
CompletedFirst Submitted
Initial submission to the registry
July 27, 2006
CompletedFirst Posted
Study publicly available on registry
July 31, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 11, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
October 11, 2012
CompletedResults Posted
Study results publicly available
December 13, 2013
CompletedNovember 8, 2022
November 1, 2022
6.4 years
July 27, 2006
October 23, 2013
November 4, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Time to All Cause Death or First Hospitalization for Worsening Heart Failure
Time to death from any cause or first hospital admission for worsening heart failure (adjudicated by the Clinical Endpoint Committee), whichever occurred first, estimated by Kaplan-Meier method. Participants not experiencing a qualifying event during the study were censored at their last contact time or the study termination date, whichever occurred first.
From randomization to the end of study; maximum time on study was 73 months
Secondary Outcomes (4)
Time to Death From Any Cause
From randomization to the end of study; maximum time on study was 73 months
Time to Cardiovascular Death or First Hospital Admission for Worsening Heart Failure
From randomization to the end of study; maximum time on study was 73 months
Change From Baseline to Month 6 in Kansas City Cardiomyopathy Questionnaire (KCCQ) Overall Summary Score
Baseline and Month 6
Change From Baseline to Month 6 in KCCQ Symptom Frequency Score
Baseline and Month 6
Study Arms (2)
Darbepoetin alfa
EXPERIMENTALStarting dose of 0.75 µg/kg subcutaneously every 2 weeks until hemoglobin concentrations reach 13.0 g/dL on 2 consecutive visits, then monthly dosing, titrated to achieve hemoglobin target of 13.0 g/dL, not to exceed 14.5 g/dL.
Placebo
PLACEBO COMPARATORParticipants received dose and administration schedule (every 2 weeks or once a month) changes that simulated the changes for participants receiving darbepoetin alfa.
Interventions
Eligibility Criteria
You may qualify if:
- Heart failure of at least 3 months duration and of New York Heart Association (NYHA) class II, III, or IV
- hemoglobin between 9.0 g/dL and 12.0 g/dL
- left ventricular ejection fraction equal to or less than 40%
You may not qualify if:
- Transferrin saturation (Tsat) \< 15%
- Blood pressure \> 160/100 mm Hg
- Heart failure primarily due to valvular heart disease or clinically significant valvular heart disease that might lead to surgical correction within 12 months of randomization
- Recipient of a major organ transplant or receiving renal replacement therapy
- Serum creatinine \> 3.0 mg/dL (\> 265 µmol/L)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Amgenlead
Study Sites (754)
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Birmingham, Alabama, 35211, United States
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Birmingham, Alabama, 35294, United States
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Huntsville, Alabama, 35801, United States
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Mobile, Alabama, 36608, United States
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Gilbert, Arizona, 85296, United States
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Mesa, Arizona, 85206, United States
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Scottsdale, Arizona, 85251, United States
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Tucson, Arizona, 85723, United States
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Little Rock, Arkansas, 72204, United States
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Little Rock, Arkansas, 72205, United States
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Anaheim, California, 92801, United States
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Buena Park, California, 90621, United States
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Corona, California, 92879, United States
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Culver City, California, 90232, United States
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Downey, California, 90241, United States
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La Jolla, California, 92037, United States
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Lancaster, California, 93534, United States
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Larkspur, California, 94939, United States
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Loma Linda, California, 92354, United States
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Long Beach, California, 90822, United States
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Los Angeles, California, 90017, United States
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Los Angeles, California, 90024, United States
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Los Angeles, California, 90033-1026, United States
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Los Angeles, California, 90048, United States
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Los Angeles, California, 90073, United States
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Modesto, California, 95355, United States
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Oakland, California, 94609, United States
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Pasadena, California, 91105, United States
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Redondo Beach, California, 90277, United States
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Sacramento, California, 95819, United States
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Sacramento, California, 95825, United States
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San Diego, California, 92120, United States
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San Francisco, California, 94115, United States
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San Francisco, California, 94118, United States
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Santa Monica, California, 90404, United States
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Santa Rosa, California, 95405, United States
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Sylmar, California, 91342, United States
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Walnut Creek, California, 94598, United States
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Westlake Village, California, 91361, United States
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Aurora, Colorado, 80012, United States
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Colorado Springs, Colorado, 80907, United States
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Denver, Colorado, 80218, United States
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Littleton, Colorado, 80120, United States
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Loveland, Colorado, 80538, United States
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Bridgeport, Connecticut, 06606, United States
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Fairfield, Connecticut, 06430, United States
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Washington D.C., District of Columbia, 20010, United States
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Washington D.C., District of Columbia, 20422, United States
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Jacksonville, Florida, 32207, United States
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Jacksonville, Florida, 32209, United States
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Jacksonville, Florida, 32258, United States
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Jacksonville Beach, Florida, 32250, United States
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Jupiter, Florida, 33458, United States
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Melbourne, Florida, 32901, United States
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Miami, Florida, 33133, United States
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Miami Beach, Florida, 33140, United States
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Orlando, Florida, 32803, United States
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Port Charlotte, Florida, 33952, United States
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Safety Harbor, Florida, 34695, United States
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Sarasota, Florida, 34239, United States
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St. Petersburg, Florida, 33701, United States
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St. Petersburg, Florida, 33705, United States
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Tamarac, Florida, 33321, United States
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Tampa, Florida, 33609, United States
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Atlanta, Georgia, 30308, United States
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Atlanta, Georgia, 30342, United States
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Augusta, Georgia, 30901, United States
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Covington, Georgia, 30014, United States
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Rome, Georgia, 30165, United States
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Meridian, Idaho, 83642, United States
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Chicago, Illinois, 60611, United States
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Elk Grove Village, Illinois, 60007, United States
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Evanston, Illinois, 60202, United States
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Hinsdale, Illinois, 60521, United States
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Maywood, Illinois, 60153, United States
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Melrose Park, Illinois, 60160, United States
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Oak Lawn, Illinois, 60453, United States
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Oakbrook Terrace, Illinois, 60181, United States
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Peoria, Illinois, 61606, United States
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Rockford, Illinois, 61107, United States
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Springfield, Illinois, 62701, United States
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Springfield, Illinois, 62702, United States
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Anderson, Indiana, 46011, United States
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Fort Wayne, Indiana, 46805, United States
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Indianapolis, Indiana, 46202, United States
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Indianapolis, Indiana, 46250, United States
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Indianapolis, Indiana, 46260, United States
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Jeffersonville, Indiana, 47130, United States
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Valparaiso, Indiana, 46383, United States
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Des Moines, Iowa, 50314, United States
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Iowa City, Iowa, 52242, United States
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Iowa City, Iowa, 52245, United States
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Kansas City, Kansas, 66160, United States
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Olathe, Kansas, 66061, United States
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Wichita, Kansas, 67214, United States
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Louisville, Kentucky, 40202, United States
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Louisville, Kentucky, 40207, United States
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Madisonville, Kentucky, 42431, United States
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Alexandria, Louisiana, 71301, United States
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Covington, Louisiana, 70433, United States
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Lake Charles, Louisiana, 70601, United States
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Marrero, Louisiana, 70072, United States
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Slidell, Louisiana, 70458, United States
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South Portland, Maine, 04106, United States
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Annapolis, Maryland, 21401, United States
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Baltimore, Maryland, 21287, United States
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Salisbury, Maryland, 21804, United States
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Ayer, Massachusetts, 01432, United States
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Boston, Massachusetts, 02115, United States
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Boston, Massachusetts, 02118, United States
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Haverhill, Massachusetts, 01830, United States
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Natick, Massachusetts, 01760, United States
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North Dartmouth, Massachusetts, 02747, United States
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West Roxbury, Massachusetts, 02132, United States
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Whitman, Massachusetts, 02382, United States
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Worcester, Massachusetts, 01604, United States
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Worcester, Massachusetts, 01655, United States
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Detroit, Michigan, 48201, United States
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Detroit, Michigan, 48202, United States
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Grand Rapids, Michigan, 49503, United States
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Lansing, Michigan, 48910, United States
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Muskegon, Michigan, 49444, United States
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Petoskey, Michigan, 49770, United States
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Saginaw, Michigan, 48601, United States
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Southfield, Michigan, 48075, United States
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Duluth, Minnesota, 55805, United States
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Minneapolis, Minnesota, 55304, United States
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Minneapolis, Minnesota, 55417, United States
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Minneapolis, Minnesota, 55455, United States
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Saint Louis Park, Minnesota, 55426, United States
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Saint Paul, Minnesota, 55102, United States
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Columbia, Missouri, 65201, United States
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Kansas City, Missouri, 64108, United States
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Kansas City, Missouri, 64111, United States
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St Louis, Missouri, 63104, United States
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St Louis, Missouri, 63110, United States
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St Louis, Missouri, 63122, United States
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Kalispell, Montana, 59901, United States
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Missoula, Montana, 59802, United States
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Grand Island, Nebraska, 68803, United States
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Lincoln, Nebraska, 68506, United States
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Lincoln, Nebraska, 68526, United States
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Lebanon, New Hampshire, 03756, United States
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Hackensack, New Jersey, 07601, United States
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Morristown, New Jersey, 07962, United States
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Newark, New Jersey, 07103, United States
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Newark, New Jersey, 07112, United States
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Summit, New Jersey, 07902, United States
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Westwood, New Jersey, 07675, United States
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Albuquerque, New Mexico, 87131, United States
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Buffalo, New York, 14221, United States
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Cortlandt Manor, New York, 10567, United States
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Flushing, New York, 11355, United States
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Garden City, New York, 11530, United States
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Johnson City, New York, 13790, United States
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Kingston, New York, 12401, United States
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New York, New York, 10001, United States
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New York, New York, 10016, United States
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New York, New York, 10019, United States
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New York, New York, 10021, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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Rochester, New York, 14618, United States
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Staten Island, New York, 10305, United States
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Syracuse, New York, 13210, United States
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The Bronx, New York, 10461, United States
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The Bronx, New York, 10467, United States
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Troy, New York, 12180, United States
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West Islip, New York, 11795, United States
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Williamsville, New York, 14221, United States
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Asheville, North Carolina, 28803, United States
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Burlington, North Carolina, 27215, United States
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Chapel Hill, North Carolina, 27599, United States
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Charlotte, North Carolina, 28204, United States
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Durham, North Carolina, 27705, United States
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Gastonia, North Carolina, 28054, United States
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Greensboro, North Carolina, 27403, United States
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New Bern, North Carolina, 28562, United States
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Winston-Salem, North Carolina, 27103, United States
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Winston-Salem, North Carolina, 27157, United States
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Akron, Ohio, 44307, United States
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Canton, Ohio, 44710, United States
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Cincinnati, Ohio, 45267, United States
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Cleveland, Ohio, 44106, United States
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Cleveland, Ohio, 44109, United States
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Cleveland, Ohio, 44195, United States
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Dayton, Ohio, 45414, United States
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Garfield Heights, Ohio, 44125, United States
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Mayfield Heights, Ohio, 44124, United States
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Sandusky, Ohio, 44870, United States
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Toledo, Ohio, 43606, United States
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Oklahoma City, Oklahoma, 73104, United States
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Oklahoma City, Oklahoma, 73109, United States
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Oklahoma City, Oklahoma, 73112, United States
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Oklahoma City, Oklahoma, 73120, United States
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Tulsa, Oklahoma, 74104, United States
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Bend, Oregon, 97701, United States
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Hillsboro, Oregon, 97123, United States
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Portland, Oregon, 97213, United States
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Allentown, Pennsylvania, 18106, United States
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Hershey, Pennsylvania, 17033, United States
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Lancaster, Pennsylvania, 17603, United States
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Philadelphia, Pennsylvania, 19102, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19107, United States
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Philadelphia, Pennsylvania, 19140, United States
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Philadelphia, Pennsylvania, 19141, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Pittsburgh, Pennsylvania, 15224, United States
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Sayre, Pennsylvania, 18840, United States
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Wyomissing, Pennsylvania, 19610, United States
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Pawtucket, Rhode Island, 02860, United States
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Anderson, South Carolina, 29621, United States
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Charleston, South Carolina, 29401, United States
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Charleston, South Carolina, 29403, United States
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Columbia, South Carolina, 29204, United States
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Orangeburg, South Carolina, 29115, United States
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Spartanburg, South Carolina, 29303, United States
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Chattanooga, Tennessee, 37404, United States
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Germantown, Tennessee, 38138, United States
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Jackson, Tennessee, 38305, United States
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Memphis, Tennessee, 38104, United States
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Memphis, Tennessee, 38120, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232-8802, United States
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Tullahoma, Tennessee, 37388, United States
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Beaumont, Texas, 77702, United States
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Dallas, Texas, 75216, United States
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Dallas, Texas, 75226, United States
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Dallas, Texas, 75230, United States
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Dallas, Texas, 75231, United States
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Dallas, Texas, 75390, United States
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Galveston, Texas, 77555, United States
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Houston, Texas, 77004, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77074, United States
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Lubbock, Texas, 79410, United States
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Odessa, Texas, 79763, United States
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San Antonio, Texas, 78217, United States
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Tyler, Texas, 75708, United States
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Salt Lake City, Utah, 84148, United States
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Annandale, Virginia, 22003, United States
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Midlothian, Virginia, 23114, United States
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Richmond, Virginia, 23249, United States
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Roanoke, Virginia, 24014, United States
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Bellingham, Washington, 98225, United States
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Kirkland, Washington, 98034, United States
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Seattle, Washington, 98195, United States
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Tacoma, Washington, 98405, United States
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Beloit, Wisconsin, 53511, United States
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Madison, Wisconsin, 53707, United States
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Madison, Wisconsin, 53792, United States
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Milwaukee, Wisconsin, 53215, United States
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Adrogué, Buenos Aires, 1836, Argentina
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Bahía Blanca, Buenos Aires, 8000, Argentina
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Capital Federal, Buenos Aires, C1408INH, Argentina
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Capital Federal, Buenos Aires, C1426ANZ, Argentina
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Ciudad Autónoma de Buenos Aires, Buenos Aires, 1118, Argentina
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Ciudad Autonoma de Buenos Aires, Buenos Aires, 1425, Argentina
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Coronel Suárez, Buenos Aires, 7540, Argentina
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La Plata, Buenos Aires, 1900, Argentina
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Mar del Plata, Buenos Aires, B7600FZN, Argentina
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Quilmes, Buenos Aires, B1878GEG, Argentina
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San Martín, Buenos Aires, 1650, Argentina
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Córdoba, Córdoba, X5016KEH, Argentina
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Cipolletti, RÃ-o Negro, R8324EMD, Argentina
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Rosario, Santa Fe Province, S2000CVD, Argentina
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Buenos Aires, 1155, Argentina
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Buenos Aires, B1708KCH, Argentina
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Buenos Aires, C1181ACH, Argentina
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Buenos Aires, C1280AEB, Argentina
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Buenos Aires, C1405BCH, Argentina
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Buenos Aires, C1416DRJ, Argentina
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Capital Federal, C1221ADC, Argentina
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Corrientes, W3400AMZ, Argentina
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Córdoba, 5000, Argentina
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Córdoba, X5004CDT, Argentina
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Mendoza, 5500, Argentina
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Salta, A4406CLA, Argentina
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Santa Fe, 3000, Argentina
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Camperdown, New South Wales, 2050, Australia
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Coffs Harbour, New South Wales, 2450, Australia
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Concord, New South Wales, 2139, Australia
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Gosford, New South Wales, 2250, Australia
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New Lambton Heights, New South Wales, 2305, Australia
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Randwick, New South Wales, 2031, Australia
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Chermside, Queensland, 4032, Australia
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Kippa-Ring, Queensland, 4021, Australia
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Woolloongabba, Queensland, 4102, Australia
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Bedford Park, South Australia, 5042, Australia
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Geelong, Victoria, 3220, Australia
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Heidelberg, Victoria, 3084, Australia
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Parkville, Victoria, 3052, Australia
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Prahran, Victoria, 3181, Australia
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Nedlands, Western Australia, 6009, Australia
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Innsbruck, 6020, Austria
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Linz, 4010, Austria
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Linz, 4021, Austria
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Salzburg, 5020, Austria
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Vienna, 1090, Austria
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Vienna, 1150, Austria
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Wels, 4600, Austria
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Aalst, 9300, Belgium
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Antwerp, 2020, Belgium
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Antwerp, 2060, Belgium
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Bonheiden, 2820, Belgium
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Bruges, 8000, Belgium
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Brussels, 1070, Belgium
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Brussels, 1090, Belgium
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Genk, 3600, Belgium
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Ghent, 9000, Belgium
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Hasselt, 3500, Belgium
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Huy, 4500, Belgium
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Leuven, 3000, Belgium
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Roeselare, 8800, Belgium
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Turnhout, 2300, Belgium
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Fortaleza, Ceará, 60864-194, Brazil
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Salvador, Estado de Bahia, 40144-900, Brazil
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Goiânia, Goiás, 74605-050, Brazil
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Belo Horizonte, Minas Gerais, 30110-908, Brazil
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Curitiba, Paraná, 80010-030, Brazil
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Recife, Pernambuco, 50100-060, Brazil
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Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Porto Alegre, Rio Grande do Sul, 90620-001, Brazil
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Campinas, São Paulo, 13059-740, Brazil
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Riberão Preto, São Paulo, 14048-900, Brazil
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São Paulo, São Paulo, 04012-909, Brazil
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São Paulo, São Paulo, 05403-900, Brazil
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São José Do Rio Preto, São Paulo, 15090-000, Brazil
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São Paulo, São Paulo, 04025-002, Brazil
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Rio de Janeiro, 20020-020, Brazil
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Rio de Janeiro, 20551-030, Brazil
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Rio de Janeiro, 22271-100, Brazil
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Dimitrovgrad, 6400, Bulgaria
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Haskovo, 6300, Bulgaria
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Pleven, 5800, Bulgaria
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Plovdiv, 4000, Bulgaria
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Plovdiv, 4002, Bulgaria
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Plovdiv, 4003, Bulgaria
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Rousse, 7002, Bulgaria
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Sofia, 1202, Bulgaria
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Sofia, 1233, Bulgaria
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Sofia, 1309, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1527, Bulgaria
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Sofia, 1606, Bulgaria
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Varna, 9010, Bulgaria
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Veliko Tarnovo, 5000, Bulgaria
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Calgary, Alberta, T2E 7C5, Canada
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Edmonton, Alberta, T6G 2B7, Canada
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Edmonton, Alberta, T6K 4C1, Canada
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Campbell River, British Columbia, V9W 5Y4, Canada
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Surrey, British Columbia, V3V 1Z2, Canada
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Winnipeg, Manitoba, R3C 0N2, Canada
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Winnipeg, Manitoba, R3T 2E8, Canada
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St. John's, Newfoundland and Labrador, A1B 3V6, Canada
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Halifax, Nova Scotia, B3H 3A7, Canada
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Ajax, Ontario, L1S 7K8, Canada
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Cambridge, Ontario, N1R 7R1, Canada
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Hamilton, Ontario, L8L 2X2, Canada
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Kingston, Ontario, K7L 1C2, Canada
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London, Ontario, N6A 5A5, Canada
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Mississauga, Ontario, L5B 4A2, Canada
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North York, Ontario, M2K 2W2, Canada
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Ottawa, Ontario, K1Y 4W7, Canada
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Scarborough Village, Ontario, M1E 5E9, Canada
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Scarborough Village, Ontario, M1P 2V5, Canada
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Toronto, Ontario, M5B 1W8, Canada
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Toronto, Ontario, M5G 1X5, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H2W 1T7, Canada
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Montreal, Quebec, H2W 1T8, Canada
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Montreal, Quebec, H3A 1A1, Canada
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Montreal, Quebec, H3G 1A4, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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St-Jérôme, Quebec, J7Z 5T3, Canada
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Regina, Saskatchewan, S4P 3X3, Canada
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Saskatoon, Saskatchewan, S7H 5H9, Canada
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Rancagua, Cachapoal, 2841959, Chile
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La Serena, Elqui, 1731295, Chile
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San Miguel, Santiago Metropolitan, 8900085, Chile
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Osorno, Chile
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Santiago, 7500922, Chile
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Santiago, 8320000, Chile
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Santiago, 8330032, Chile
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Santiago, Chile
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Temuco, 4781151, Chile
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Viña del Mar, Chile
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Benešov, 256 01, Czechia
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Brno, 656 91, Czechia
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České Budějovice, 370 87, Czechia
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Jihlava, 586 01, Czechia
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Karlovy Vary, 360 01, Czechia
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Pardubice, 530 02, Czechia
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Prague, 100 34, Czechia
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Prague, 108 00, Czechia
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Prague, 110 00, Czechia
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Prague, 120 00, Czechia
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Prague, 128 08, Czechia
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Příbram, 261 01, Czechia
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Tábor, 390 03, Czechia
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Ústí nad Labem, 401 13, Czechia
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Fredericia, 7000, Denmark
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Frederiksberg, 2000, Denmark
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Frederikshavn, 9900, Denmark
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Glostrup Municipality, 2600, Denmark
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Hellerup, 2900, Denmark
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Herlev, 2730, Denmark
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Horsens, 8700, Denmark
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Hvidovre, 2650, Denmark
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København Ø, 2011, Denmark
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København S, 2300, Denmark
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Køge, 4600, Denmark
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Odense, 5000, Denmark
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Roskilde, 4000, Denmark
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Svendborg, 5700, Denmark
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Pärnu, 80010, Estonia
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Tallinn, 10138, Estonia
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Tallinn, 10617, Estonia
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Tallinn, 13419, Estonia
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Espoo, 00029, Finland
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Related Publications (5)
McMurray JJ, Anand IS, Diaz R, Maggioni AP, O'Connor C, Pfeffer MA, Polu KR, Solomon SD, Sun Y, Swedberg K, Tendera M, van Veldhuisen DJ, Wasserman SM, Young JB; RED-HF Committees and Investigators. Design of the Reduction of Events with Darbepoetin alfa in Heart Failure (RED-HF): a Phase III, anaemia correction, morbidity-mortality trial. Eur J Heart Fail. 2009 Aug;11(8):795-801. doi: 10.1093/eurjhf/hfp098.
PMID: 19633103BACKGROUNDSwedberg K, Young JB, Anand IS, Cheng S, Desai AS, Diaz R, Maggioni AP, McMurray JJ, O'Connor C, Pfeffer MA, Solomon SD, Sun Y, Tendera M, van Veldhuisen DJ; RED-HF Committees; RED-HF Investigators. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med. 2013 Mar 28;368(13):1210-9. doi: 10.1056/NEJMoa1214865. Epub 2013 Mar 10.
PMID: 23473338BACKGROUNDChung EY, Palmer SC, Saglimbene VM, Craig JC, Tonelli M, Strippoli GF. Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis. Cochrane Database Syst Rev. 2023 Feb 13;2(2):CD010590. doi: 10.1002/14651858.CD010590.pub3.
PMID: 36791280DERIVEDAbraityte A, Aukrust P, Kou L, Anand IS, Young J, Mcmurray JJV, van Veldhuisen DJ, Gullestad L, Ueland T. T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF. Clin Res Cardiol. 2019 Feb;108(2):133-141. doi: 10.1007/s00392-018-1331-2. Epub 2018 Jul 26.
PMID: 30051179DERIVEDvan der Meer P, Grote Beverborg N, Pfeffer MA, Olson K, Anand IS, Westenbrink BD, McMurray JJV, Swedberg K, Young JB, Solomon SD, van Veldhuisen DJ. Hyporesponsiveness to Darbepoetin Alfa in Patients With Heart Failure and Anemia in the RED-HF Study (Reduction of Events by Darbepoetin Alfa in Heart Failure): Clinical and Prognostic Associations. Circ Heart Fail. 2018 Feb;11(2):e004431. doi: 10.1161/CIRCHEARTFAILURE.117.004431.
PMID: 29367268DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Study Director
- Organization
- Amgen Inc.
Study Officials
- STUDY DIRECTOR
MD
Amgen
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 27, 2006
First Posted
July 31, 2006
Study Start
June 1, 2006
Primary Completion
October 11, 2012
Study Completion
October 11, 2012
Last Updated
November 8, 2022
Results First Posted
December 13, 2013
Record last verified: 2022-11