Measuring Time Windows in Patients With Schizophrenia and Healthy Controls
Relating the 'Experienced Present' With the Mechanisms of Neuronal Function: A Comparative Study in Patients With Schizophrenia and Healthy Controls Using Psychophysical and Neurophysiological Methods
1 other identifier
observational
126
1 country
3
Brief Summary
Abnormalities in the ability to distinguish events in time may have a great impact on everyday life. The main objective of the study is to evaluate the magnitude of the temporal windows in schizophrenia, i.e. the time interval during which two events are perceived as synchronous. The investigators test the hypothesis that these temporal windows are enlarged, and check the relationship between this impairment and disorganization symptoms, in order to explore the link between this cognitive impairment and clinical symptoms. They explore also the neurobiological bases of the impairment by means of electroencephalogram (EEG) recordings. Event-related potentials (N50) will reveal whether or not the coding of the stimuli has the same temporal characteristics in patients and controls. The distribution and amplitude of oscillatory activities will be analyzed as a function of the synchronous or asynchronous response of the subject, thus allowing to explore the links between synchrony perception and neuronal synchronization phenomena.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2005
Longer than P75 for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2005
CompletedFirst Submitted
Initial submission to the registry
July 10, 2006
CompletedFirst Posted
Study publicly available on registry
July 11, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedOctober 5, 2017
September 1, 2017
6.6 years
July 10, 2006
October 4, 2017
Conditions
Keywords
Study Arms (2)
Healthy volunteers
Patients
Interventions
Eligibility Criteria
Primary care clinic, residents of Strasbourg
You may qualify if:
- Patients with schizophrenia (DSM-IV criteria)
- Healthy controls matched with patients on age, sex and education level
- Age between 18 and 50
- Informed consent signed
- No severe somatic illness
- No invalidating sensory disease
- No drug abuse, as defined by DSM-IV criteria
- No general anesthesia in the past 3 months
- No intake of drug affecting the CNS, except for patients
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Service de Psychiatrie Adulte & INSERM U841, Hôpital Albert Chenevier et Henri Mondor (AP-HP)
Créteil, 94000, France
Centre Hospitalier de Rouffach
Rouffach, 68250, France
INSERM U666 - Département de Psychiatrie - Hôpitaux Universitaires de Strasbourg
Strasbourg, 67091, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Anne GIERSCH, MD
Institut National de la Santé Et de la Recherche Médicale, France
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 10, 2006
First Posted
July 11, 2006
Study Start
September 1, 2005
Primary Completion
April 1, 2012
Study Completion
December 1, 2012
Last Updated
October 5, 2017
Record last verified: 2017-09