Improvement in Memory With Plasticity-Based Adaptive Cognitive Training (IMPACT)

NCT00283010 | Completed

• 1 other identifier: OUT-105-2005
• Study Type: interventional
• Target: 487
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to evaluate the effects of a computer-based training program on the memory and cognitive abilities of mature individuals undergoing healthy aging.

Conditions

Aging

Keywords

cognitive enhancement; memory; auditory memory; speech; computerized; cognitive decline

Outcome Measures

Primary Outcomes (1)

• Cognitive effects of training

  6 months

Secondary Outcomes (1)

• Safety effects of computer-based training

  6 months

Study Arms (2)

Experimental Treatment

EXPERIMENTAL

Computerized Plasticity-Based Adaptive Cognitive Training

Other: Computerized Plasticity-Based Adaptive Cognitive Training

Active Control

ACTIVE COMPARATOR

Educational DVDs

Other: Educational DVDs

Interventions

Computerized Plasticity-Based Adaptive Cognitive Training OTHER

Also known as: BrainHQ, Brain Fitness Program

Experimental Treatment

Educational DVDs OTHER

Active Control

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Age 65 or older at the time of consent.
• Mini-Mental State Examination (MMSE) score of 26 or higher.
• Fluent English speaker. For the purposes of this study, fluency will be defined as living in an English speaking country and attending an English speaking school by the age of six (participants will demonstrate fluency by reading aloud a selected paragraph).
• Visual capacity adequate to read 14 point type (participants will demonstrate visual capacity by reading aloud a selected sentence).
• Adequate hearing capacity. (Participants will demonstrate by repeating a series of words spoken by the screening clinician; the words will be spoken while a view of the clinician's mouth is obstructed to prevent lip-reading.)
• Willing and able to commit to the 6-month time requirement of the entire study period with an emphasis on availability for the 8-10 week computer based training.

You may not qualify if:

• Mini-Mental State Examination (MMSE) score of 25 or lower.
• Self-report of current diagnosis or history of major neurological illness. Specifically:
• Alzheimer's disease
• Parkinson's disease
• Multiple sclerosis
• Amyotrophic lateral sclerosis
• Self-report of current diagnosis or history of psychiatric illness. Specifically:
• Major depressive disorder
• Bipolar disorder
• Schizophrenia
• Post traumatic stress disorder
• Obsessive-compulsive disorder
• Self-reported history of psychiatric hospitalization.
• History of a stroke, transient ischemic attack (TIA), or traumatic brain injury within the past year; or lifetime history of stroke, TIA, or traumatic brain injury that has left residual expressive or receptive language problems. Traumatic brain injuries include, but are not limited to: concussion with loss of consciousness; head trauma with loss of consciousness; persistent migraines (persistent being defined as a predictable pattern occurring more frequently than every other month); and history of seizure disorder.
• Fibromyalgia or symptoms of tremor severe enough to prevent the use of a computer mouse or other pointing device. Clinician to observe participant during signature of consent form, during drawing portion of Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) assessment, and to directly ask participant as instructed in the Body Image Ideals Questionnaire (BIQ) to make tremor assessment.

Sponsors & Collaborators

• Posit Science Corporation: lead
• Mayo Clinic: collaborator
• University of Southern California: collaborator

Study Sites (1)

Posit Science Corporation

San Francisco, California, 94108, United States

Location

Related Publications (3)

• Smith GE, Housen P, Yaffe K, Ruff R, Kennison RF, Mahncke HW, Zelinski EM. A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc. 2009 Apr;57(4):594-603. doi: 10.1111/j.1532-5415.2008.02167.x. Epub 2009 Feb 9.

  PMID: 19220558 RESULT

• Zelinski EM, Spina LM, Yaffe K, Ruff R, Kennison RF, Mahncke HW, Smith GE. Improvement in memory with plasticity-based adaptive cognitive training: results of the 3-month follow-up. J Am Geriatr Soc. 2011 Feb;59(2):258-65. doi: 10.1111/j.1532-5415.2010.03277.x.

  PMID: 21314646 RESULT

• Zelinski EM, Peters KD, Hindin S, Petway KT 2nd, Kennison RF. Evaluating the relationship between change in performance on training tasks and on untrained outcomes. Front Hum Neurosci. 2014 Aug 13;8:617. doi: 10.3389/fnhum.2014.00617. eCollection 2014.

  PMID: 25165440 RESULT

MeSH Terms

Conditions

Speech; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Verbal Behavior; Communication; Behavior; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Henry W Mahncke, PhD

  Posit Science Corporation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 25, 2006
• First Posted: January 27, 2006
• Study Start: January 1, 2006
• Primary Completion: April 1, 2008
• Study Completion: April 1, 2008
• Last Updated: November 2, 2015

Record last verified: 2015-10

Locations

US (1)