A Study of Factors That Affect Long-Term Kidney Transplant Function
DeKAF
Study of Long-term Deterioration of Kidney Allograft Function (DeKAF)
1 other identifier
observational
3,175
2 countries
7
Brief Summary
The causes of deterioration of transplanted kidney function are poorly understood. The purpose of this study is to determine the disease processes that cause transplanted kidney dysfunction and loss in patients who received a kidney either recently or over a year prior to entering this study. This study will also identify specific characteristics in kidney transplant recipients that predict whether a kidney transplant will be successful.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2005
Longer than P75 for all trials
7 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2005
CompletedFirst Submitted
Initial submission to the registry
December 27, 2005
CompletedFirst Posted
Study publicly available on registry
December 28, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2018
CompletedNovember 1, 2019
October 1, 2019
13.3 years
December 27, 2005
October 30, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Kidney transplant failure
throughout study (for prospective cohort)
Study Arms (2)
Retrospective Cohort
537 transplant recipient records used retrospectively
Prospective Cohort
3137 transplant recipients enrolled prospectively
Eligibility Criteria
Kidney transplant recipients
You may qualify if:
- Received a kidney transplant within 10 days prior to study entry, on or after 10-01-2005
- Recipient of kidney or simultaneous kidney/pancreas with no additional transplant at the time of the kidney transplant
- Received a kidney transplant before 10-01-2005
- Recipient of kidney or simultaneous kidney/pancreas with no additional transplant at the time of the kidney transplant
- Undergoes a clinically indicated kidney biopsy due to new onset deterioration of function, defined as having an increase in serum creatinine
- The creatinine level on or before 01-01-2006 must be 2 mg/dl or less OR the patient must have developed new onset proteinuria, defined as having a protein/creatinine ratio of 0.4 or more
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Minnesotalead
- Astellas Pharma Inccollaborator
- Bristol-Myers Squibbcollaborator
- Novartiscollaborator
- Pfizercollaborator
- Sanoficollaborator
Study Sites (7)
University of Alabama - Division of Nephrology
Birmingham, Alabama, 35294, United States
University of Iowa - Nephrology Division
Iowa City, Iowa, 52242, United States
Hennepin County Medical Center - Division of Nephrology
Minneapolis, Minnesota, 55415, United States
University of Minnesota Dept of Surgery - Transplantation Division
Minneapolis, Minnesota, 55455, United States
Mayo Clinic - Division of Nephrology
Rochester, Minnesota, 55905, United States
University of Alberta - Division of Nephrology & Immunology
Edmonton, Alberta, T6G 2S2, Canada
Health Sciences Center - Section of Nephrology
Winnipeg, Manitoba, R3A 1R9, Canada
Related Publications (6)
Hariharan S, Kasiske B, Matas A, Cohen A, Harmon W, Rabb H. Surrogate markers for long-term renal allograft survival. Am J Transplant. 2004 Jul;4(7):1179-83. doi: 10.1111/j.1600-6143.2004.00484.x.
PMID: 15196079BACKGROUNDKasiske BL, Gaston RS, Gourishankar S, Halloran PF, Matas AJ, Jeffery J, Rush D. Long-term deterioration of kidney allograft function. Am J Transplant. 2005 Jun;5(6):1405-14. doi: 10.1111/j.1600-6143.2005.00853.x.
PMID: 15888048BACKGROUNDMatas AJ, Helgeson E, Fieberg A, Leduc R, Gaston RS, Kasiske BL, Rush D, Hunsicker L, Cosio F, Grande JP, Cecka JM, Connett J, Mannon RB. Risk Prediction for Delayed Allograft Function: Analysis of the Deterioration of Kidney Allograft Function (DeKAF) Study Data. Transplantation. 2022 Feb 1;106(2):358-368. doi: 10.1097/TP.0000000000003718.
PMID: 33675321DERIVEDGrande JP, Helgeson ES, Matas AJ. Correlation of Glomerular Size With Donor-Recipient Factors and With Response to Injury. Transplantation. 2021 Nov 1;105(11):2451-2460. doi: 10.1097/TP.0000000000003570.
PMID: 33273317DERIVEDOetting WS, Schladt DP, Dorr CR, Wu B, Guan W, Remmel RP, Ikle D, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN03 Investigators. Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A. Transplantation. 2019 Aug;103(8):1591-1602. doi: 10.1097/TP.0000000000002659.
PMID: 30801535DERIVEDSeibert SR, Schladt DP, Wu B, Guan W, Dorr C, Remmel RP, Matas AJ, Mannon RB, Israni AK, Oetting WS, Jacobson PA. Tacrolimus trough and dose intra-patient variability and CYP3A5 genotype: Effects on acute rejection and graft failure in European American and African American kidney transplant recipients. Clin Transplant. 2018 Dec;32(12):e13424. doi: 10.1111/ctr.13424. Epub 2018 Oct 31.
PMID: 30318646DERIVED
Biospecimen
Blood and urine specimens.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Arthur J. Matas, MD
University of Minnesota
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 27, 2005
First Posted
December 28, 2005
Study Start
October 1, 2005
Primary Completion
December 31, 2018
Study Completion
December 31, 2018
Last Updated
November 1, 2019
Record last verified: 2019-10