NCT00125216

Brief Summary

The purpose of this study is to evaluate the effects of Response Elaboration Training (RET), which is a speech/language therapy for aphasia. The study is designed to determine whether verbal language production improves in terms of content and length of utterances as a result of treatment.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
47

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Dec 2004

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2004

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

July 27, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 29, 2005

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2007

Completed
5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
Last Updated

April 7, 2014

Status Verified

April 1, 2014

Enrollment Period

3 years

First QC Date

July 27, 2005

Last Update Submit

April 4, 2014

Conditions

Keywords

AphasiaLanguage TherapyRehabilitation of speech and language disordersSpeech-language pathology

Outcome Measures

Primary Outcomes (1)

  • verbal production of meaningful content words in connected speech

    Participants were asked to describe pictured scenes and to provide a monologue on a topic of their choice. Their speech/language was audio recorded during these tasks and recordings were transcribed by project speech/language pathologists. Counts of content words were made.

    3 and 6 weeks following completion of treatment

Study Arms (1)

Arm 1

OTHER

Single subject design - participant receives three administrations of the same treatment

Behavioral: Response Elaboration Training

Interventions

Therapist modeling, reinforcement and forward-chaining are used to stimulate verbal descriptions of pictures

Arm 1

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of moderate to severe nonfluent or fluent aphasia
  • Nonverbal intelligence within normal limits
  • Auditory and visual acuity adequate for experimental tasks
  • months post-onset of single, focal brain injury (e.g., stroke)

You may not qualify if:

  • Previous history of therapy with RET
  • Diagnosed psychological disorder other than depression
  • Neurological condition other than that which resulted in aphasia
  • History of alcohol or substance abuse
  • Non-native English speaker
  • Premorbid history of speech/language disorder

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

VA Salt Lake City Health Care System, Salt Lake City

Salt Lake City, Utah, 84148, United States

Location

Related Publications (1)

  • Wambaugh JL, Nessler C, Wright S. Modified response elaboration training: application to procedural discourse and personal recounts. Am J Speech Lang Pathol. 2013 May;22(2):S409-25. doi: 10.1044/1058-0360(2013/12-0063).

MeSH Terms

Conditions

AphasiaLanguage DisordersSpeech Disorders

Condition Hierarchy (Ancestors)

Communication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Julie L. Wambaugh, PhD

    VA Salt Lake City Health Care System, Salt Lake City

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
FED
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 27, 2005

First Posted

July 29, 2005

Study Start

December 1, 2004

Primary Completion

December 1, 2007

Study Completion

December 1, 2012

Last Updated

April 7, 2014

Record last verified: 2014-04

Locations