tDCS and Aphasia Treatment

NCT01922245 | Completed DMC

• 1 other identifier: 062951
• Study Type: interventional
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

This project will investigate the use of noninvasive brain stimulation in the form of tDCS (transcranial direct current stimulation) in conjunction with speech-language therapy, for the improvement of language production in stroke survivors with aphasia. The hypothesis is that anodal tDCS and speech-language therapy will facilitate improved outcomes compared to speech therapy alone.

Conditions

Aphasia

Keywords

aphasia; therapy; stroke; language; naming; quality of life; tDCS; treatment

Outcome Measures

Primary Outcomes (1)

• change in naming performance in singles words and sentence context

  Naming will be tested using standardized tests such at the Boston Naming Test and or the Philadelphia Naming Test. In addition, sentence probes have been created that will assess naming in the sentence context throughout the study.

  change from baseline naming performance at two weeks and four weeks post treatment

Secondary Outcomes (2)

• change in sentence production

  change from baseline performance at two weeks and four weeks post treatment

• change in health related quality of life

  change from baseline performance at two weeks and four weeks post treatment

Study Arms (1)

anodal tDCS

EXPERIMENTAL

Soterix 1x1 device: anodal tDCS administered to the left hemisphere

Device: Soterix 1x1 tDCS

Interventions

Soterix 1x1 tDCS DEVICE

Anodal and sham tDCS will be administered. All of the participants will also receive behavioral speech-language therapy.

anodal tDCS

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Hunter College of City University of New York: lead

Study Sites (1)

Hunter College Brookdale Campus

New York, New York, 10010, United States

Location

Related Publications (3)

• Baker JM, Rorden C, Fridriksson J. Using transcranial direct-current stimulation to treat stroke patients with aphasia. Stroke. 2010 Jun;41(6):1229-36. doi: 10.1161/STROKEAHA.109.576785. Epub 2010 Apr 15.

  PMID: 20395612 BACKGROUND

• Fiori V, Cipollari S, Di Paola M, Razzano C, Caltagirone C, Marangolo P. tDCS stimulation segregates words in the brain: evidence from aphasia. Front Hum Neurosci. 2013 Jun 14;7:269. doi: 10.3389/fnhum.2013.00269. eCollection 2013.

  PMID: 23785323 BACKGROUND

• Elsner B, Kugler J, Pohl M, Mehrholz J. Transcranial direct current stimulation (tDCS) for improving aphasia in patients after stroke. Cochrane Database Syst Rev. 2013 Jun 25;(6):CD009760. doi: 10.1002/14651858.CD009760.pub2.

  PMID: 23799617 RESULT

MeSH Terms

Conditions

Aphasia; Stroke; Language

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Communication; Behavior

Study Officials

• Elizabeth E Galletta, PhD

  Hunter College/City University of NY

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: August 2, 2013
• First Posted: August 14, 2013
• Study Start: July 1, 2013
• Primary Completion: January 1, 2016
• Study Completion: January 1, 2016
• Last Updated: August 14, 2020

Record last verified: 2020-08

Locations

US (1)