NCT00090441

Brief Summary

To investigate the role in coronary heart disease (CHD) of intragenic variation in a network of six genes affecting lipoprotein transport and metabolism.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4,303

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2004

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2004

Completed
25 days until next milestone

First Submitted

Initial submission to the registry

August 26, 2004

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 30, 2004

Completed
3.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2008

Completed
Last Updated

January 4, 2013

Status Verified

December 1, 2012

Enrollment Period

3.9 years

First QC Date

August 26, 2004

Last Update Submit

January 3, 2013

Conditions

AtherosclerosisCardiovascular DiseasesCoronary DiseaseHeart Diseases

Outcome Measures

Primary Outcomes (1)

  • To discover all common single nucleotide polymorphisms among a set of 6 key genes in the reverse cholesterol transport system and test them for associations with angiographic coronary artery disease.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Study subjects for the primary association study were selected from Intermountain Healthcare's ongoing Angiographic Registry and DNA Bank.

Men aged ≤60 years and women ≤70 years. Approximately 3,000 subjects (∼2,000 CAD cases and ∼1,000 angiographically normal controls, matched 2:1 for sex, age, and date of registry entry) were selected. A separate set of cases with highly familial premature CAD (first-degree relative with CHD onset \<55 in men, \<65 in women) from the University of Utah Cardiovascular Genetics Family Tree Registry and a separate set of controls (randomly invited from a public records database) were enrolled as a replication set.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

MeSH Terms

Conditions

AtherosclerosisCardiovascular DiseasesCoronary DiseaseHeart Diseases

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesMyocardial Ischemia

Study Officials

  • Jeffrey Anderson, MD

    Intermountain Health Care; University of Utah School of Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

August 26, 2004

First Posted

August 30, 2004

Study Start

August 1, 2004

Primary Completion

July 1, 2008

Study Completion

July 1, 2008

Last Updated

January 4, 2013

Record last verified: 2012-12