NCT00090441

Completed

Risk Burden of Lipoprotein Metabolic Gene Haplotypes

Intermountain Health Care, Inc.Source

Other study identifiers

Sponsor study identifier

1265

Secondary identifiers

5R01HL071878-04

NIH

Study Type

observational

Actual enrollment (reported)

4,303

Locations

0 countries

Sites

N/A

Timeline

Study Start

August 2004

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

July 2008

Actual (reported)

Study Completion

July 2008

Actual (reported)

Brief Summary

To investigate the role in coronary heart disease (CHD) of intragenic variation in a network of six genes affecting lipoprotein transport and metabolism.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 4,303 participants
Study completion date: July 2008
Actual (reported)
Listed locations: 0 countries · 0 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
August 2004
Date type not reported
This date has not been verified as actual or estimated.
First Submitted
August 26, 2004
Actual (reported)
First Posted
August 30, 2004
Actual (reported)
Primary Completion
July 2008
Actual (reported)
Study Completion
July 2008
Actual (reported)

Last Updated: January 4, 2013
Status Verified: December 2012
Last Update Submitted: January 3, 2013

Conditions

Atherosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases

Outcome Measures

Primary Outcomes (1)

To discover all common single nucleotide polymorphisms among a set of 6 key genes in the reverse cholesterol transport system and test them for associations with angiographic coronary artery disease.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

Study subjects for the primary association study were selected from Intermountain Healthcare's ongoing Angiographic Registry and DNA Bank.

Men aged ≤60 years and women ≤70 years. Approximately 3,000 subjects (∼2,000 CAD cases and ∼1,000 angiographically normal controls, matched 2:1 for sex, age, and date of registry entry) were selected. A separate set of cases with highly familial premature CAD (first-degree relative with CHD onset \<55 in men, \<65 in women) from the University of Utah Cardiovascular Genetics Family Tree Registry and a separate set of controls (randomly invited from a public records database) were enrolled as a replication set.

Sponsors & Collaborators

National Heart, Lung, and Blood Institute (NHLBI)
NIHcollaborator
Intermountain Health Care, Inc.
Otherlead

MeSH Terms

Conditions

AtherosclerosisCardiovascular DiseasesCoronary DiseaseHeart Diseases

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesMyocardial Ischemia

Study Officials

Jeffrey Anderson, MD
Intermountain Health Care; University of Utah School of Medicine
PRINCIPAL INVESTIGATOR

Enrollment

4,303 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: RETROSPECTIVE
Sponsor Type: OTHER

Study Record Dates

First Submitted

August 26, 2004

First Posted

August 30, 2004

Study Start

August 2004

Date type not reported

This date has not been verified as actual or estimated.

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Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Primary Completion

July 2008

Actual (reported)

Study Completion

July 2008

Actual (reported)

Last Updated

January 4, 2013

Record last verified: 2012-12

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT00090441
Data provider: ClinicalTrials.gov
Source updated: 2013-01-04
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:34:57 UTC

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Eligibility Criteria

Sponsors & Collaborators

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Source record