Epidemiology of Atherosclerosis

NCT00005147 | Completed

• 2 other identifiers: 1018R01HL024489
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine the role of genetic factors in predicting resistance and susceptibility to coronary artery disease.

Conditions

Atherosclerosis; Cardiovascular Diseases; Heart Diseases; Coronary Arteriosclerosis

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (57)

• Mailly F, Moll P, Kottke BA, Kamboh MI, Humphries SE, Ferrell RE. Estimation of the frequency of isoform-genotype discrepancies at the apolipoprotein E locus in heterozygotes for the isoforms. Genet Epidemiol. 1992;9(4):239-48. doi: 10.1002/gepi.1370090403.

  PMID: 1398044 BACKGROUND

• Reilly SL, Ferrell RE, Kottke BA, Kamboh MI, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances. Am J Hum Genet. 1991 Dec;49(6):1155-66.

  PMID: 1842218 BACKGROUND

• Kottke BA, Moll PP, Michels VV, Weidman WH. Levels of lipids, lipoproteins, and apolipoproteins in a defined population. Mayo Clin Proc. 1991 Dec;66(12):1198-208. doi: 10.1016/s0025-6196(12)62470-7.

  PMID: 1749288 BACKGROUND

• Kamboh MI, Ferrell RE, Kottke BA. Expressed hypervariable polymorphism of apolipoprotein (a). Am J Hum Genet. 1991 Nov;49(5):1063-74.

  PMID: 1928089 BACKGROUND

• Kaprio J, Ferrell RE, Kottke BA, Kamboh MI, Sing CF. Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to risk for cardiovascular disease. Arterioscler Thromb. 1991 Sep-Oct;11(5):1330-48. doi: 10.1161/01.atv.11.5.1330.

  PMID: 1911720 BACKGROUND

• Turner ST, Michels VV. Sodium-lithium countertransport and hypertension in Rochester, Minnesota. Hypertension. 1991 Aug;18(2):183-90. doi: 10.1161/01.hyp.18.2.183.

  PMID: 1885226 BACKGROUND

• Perusse L, Moll PP, Sing CF. Evidence that a single gene with gender- and age-dependent effects influences systolic blood pressure determination in a population-based sample. Am J Hum Genet. 1991 Jul;49(1):94-105.

  PMID: 2063879 BACKGROUND

• Crews DE, Kamboh MI, Bindon JR, Ferrell RE. Genetic studies of human apolipoproteins. XVII: Population genetics of apolipoprotein polymorphisms in American Samoa. Am J Phys Anthropol. 1991 Feb;84(2):165-70. doi: 10.1002/ajpa.1330840206.

  PMID: 2021192 BACKGROUND

• Kamboh MI, Weiss KM, Ferrell RE. Genetic studies of human apolipoproteins. XVI. APOE polymorphism and cholesterol levels in the Mayans of the Yucatan Peninsula, Mexico. Clin Genet. 1991 Jan;39(1):26-32. doi: 10.1111/j.1399-0004.1991.tb02981.x.

  PMID: 1997212 BACKGROUND

• Kamboh MI, Ferrell RE. Genetic studies of human apolipoproteins. XV. An overview of IEF immunoblotting methods to screen apolipoprotein polymorphisms. Hum Hered. 1990;40(4):193-207. doi: 10.1159/000153931.

  PMID: 2199367 BACKGROUND

• Ferrell RE, Kamboh MI, Majumder PP, Valdez R, Weiss KM. Genetic studies of human apolipoproteins. XIII. Quantitative polymorphism of apolipoprotein C-III in the Mayans of the Yucatan Peninsula. Hum Hered. 1990;40(3):127-35. doi: 10.1159/000153919.

  PMID: 2365371 BACKGROUND

• Eichner JE, Kuller LH, Ferrell RE, Meilahn EN, Kamboh MI. Phenotypic effects of apolipoprotein structural variation on lipid profiles. III. Contribution of apolipoprotein E phenotype to prediction of total cholesterol, apolipoprotein B, and low density lipoprotein cholesterol in the healthy women study. Arteriosclerosis. 1990 May-Jun;10(3):379-85. doi: 10.1161/01.atv.10.3.379.

  PMID: 2344296 BACKGROUND

• Kamboh MI, Kelly LJ, Ferrell RE. Genetic studies of human apolipoproteins: XIV. A simple agarose isoelectric focusing gel method for apolipoprotein E phenotyping. Electrophoresis. 1990 Apr;11(4):314-8. doi: 10.1002/elps.1150110408.

  PMID: 2340826 BACKGROUND

• Rebbeck TR, Turner ST, Sing CF. Sodium-lithium countertransport genotype and the probability of hypertension in adults. Hypertension. 1993 Oct;22(4):560-8. doi: 10.1161/01.hyp.22.4.560.

  PMID: 8406661 BACKGROUND

• Bren ND, Rastogi A, Kottke BA. Quantification of human plasma apolipoproteins C-I, C-II, and C-III by radioimmunoassays. Mayo Clin Proc. 1993 Jul;68(7):657-64. doi: 10.1016/s0025-6196(12)60601-6.

  PMID: 8350639 BACKGROUND

• Pettitt DJ, Moll PP, Knowler WC, Mott DM, Nelson RG, Saad MF, Bennett PH, Kottke BA. Insulinemia in children at low and high risk of NIDDM. Diabetes Care. 1993 Apr;16(4):608-15. doi: 10.2337/diacare.16.4.608.

  PMID: 8462388 BACKGROUND

• Maciejko JJ, Holmes DR, Kottke BA, Zinsmeister AR, Dinh DM, Mao SJ. Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. N Engl J Med. 1983 Aug 18;309(7):385-9. doi: 10.1056/NEJM198308183090701.

  PMID: 6410239 BACKGROUND

• Moll PP, Sing CF, Weidman WH, Gordon H, Ellefson RD, Hodgson PA, Kottke BA. Total cholesterol and lipoproteins in school children: prediction of coronary heart disease in adult relatives. Circulation. 1983 Jan;67(1):127-34. doi: 10.1161/01.cir.67.1.127.

  PMID: 6847791 BACKGROUND

• Moll PP, Berry TD, Weidman WH, Ellefson R, Gordon H, Kottke BA. Detection of genetic heterogeneity among pedigrees through complex segregation analysis: an application to hypercholesterolemia. Am J Hum Genet. 1984 Jan;36(1):197-211.

  PMID: 6607671 BACKGROUND

• Moll PP, Sing CF, Lussier-Cacan S, Davignon J. An application of a model for a genotype-dependent relationship between a concomitant (age) and a quantitative trait (LDL cholesterol) in pedigree data. Genet Epidemiol. 1984;1(4):301-14. doi: 10.1002/gepi.1370010403.

  PMID: 6544242 BACKGROUND

• Kottke BA: The Role of Apolipoproteins A-I and A-II in Atherogenesis and Coronary Heart Disease: Clinical Measurements of Apolipoproteins. Perspect Lipid Disorders, 2:4-11, 1984

  BACKGROUND

• Sing CF, Boerwinkle E, Moll PP. Strategies for elucidating the phenotypic and genetic heterogeneity of a chronic disease with a complex etiology. Prog Clin Biol Res. 1985;194:39-66.

  PMID: 3906666 BACKGROUND

• Sing CF, Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet. 1985 Mar;37(2):268-85.

  PMID: 3985008 BACKGROUND

• Sing CF et al: Apolipoproteins and Cardiovascular Risk: Genetics and Epidemiology. Ann Biol Clin, 43:411-417, 1985

  BACKGROUND

• Sing CF, Boerwinkle E, Turner ST. Genetics of primary hypertension. Clin Exp Hypertens A. 1986;8(4-5):623-51. doi: 10.3109/10641968609046580.

  PMID: 3530548 BACKGROUND

• Kottke BA: Perspectives in Medicine; Apolipoprotein Markers for Coronary Artery Diseases - A Dissenting View. Drug Ther, 16:151-171, 1986

  BACKGROUND

• Boerwinkle E, Sing CF. Bias of the contribution of single-locus effects to the variance of a quantitative trait. Am J Hum Genet. 1986 Jul;39(1):137-44.

  PMID: 3463204 BACKGROUND

• Moll PP, Sing CF, Williams RR, Mao SJ, Kottke BA. The genetic determination of plasma apolipoprotein A-I levels measured by radioimmunoassay: a study of high-risk pedigrees. Am J Hum Genet. 1986 Mar;38(3):361-72.

  PMID: 3082191 BACKGROUND

• Boehnke M, Moll PP, Lange K, Weidman WH, Kottke BA. Univariate and bivariate analyses of cholesterol and triglyceride levels in pedigrees. Am J Med Genet. 1986 Mar;23(3):775-92. doi: 10.1002/ajmg.1320230306.

  PMID: 3953676 BACKGROUND

• Boerwinkle E, Chakraborty R, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet. 1986 May;50(2):181-94. doi: 10.1111/j.1469-1809.1986.tb01037.x.

  PMID: 3435047 BACKGROUND

• Kottke BA, Zinsmeister AR, Holmes DR Jr, Kneller RW, Hallaway BJ, Mao SJ. Apolipoproteins and coronary artery disease. Mayo Clin Proc. 1986 May;61(5):313-20. doi: 10.1016/s0025-6196(12)61947-8.

  PMID: 3702492 BACKGROUND

• Hurt RD, Briones ER, Offord KP, Patton JG, Mao SJ, Morse RM, Kottke BA. Plasma lipids and apolipoprotein A-I and A-II levels in alcoholic patients. Am J Clin Nutr. 1986 Apr;43(4):521-9. doi: 10.1093/ajcn/43.4.521.

  PMID: 3962905 BACKGROUND

• Badimon JJ, Kottke BA, Chen TC, Chan L, Mao SJ. Quantification and immunolocalization of apolipoprotein E in experimental atherosclerosis. Atherosclerosis. 1986 Jul;61(1):57-66. doi: 10.1016/0021-9150(86)90113-9.

  PMID: 3730054 BACKGROUND

• Au YP, Hallaway BJ, Kottke BA. Use of a quality-control plasma sample to decrease interassay variation in radioimmunoassays of apolipoprotein A-I. Clin Chem. 1986 Jul;32(7):1394-7.

  PMID: 3087660 BACKGROUND

• Au YP, Bren ND, Kottke BA. A rapid apolipoprotein E radioimmunoassay using solid-phase staphylococcus protein. Use of pooled plasma as a secondary standard. Biochem Biophys Res Commun. 1986 Jul 16;138(1):455-62. doi: 10.1016/0006-291x(86)90302-5.

  PMID: 3091017 BACKGROUND

• Kottke BA: Hyperlipoproteinemia. The Case for Individualized Care. Consultant, 26:160-169, 1986

  BACKGROUND

• Boerwinkle E, Visvikis S, Welsh D, Steinmetz J, Hanash SM, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in a sample of unrelated individuals. Am J Med Genet. 1987 Jul;27(3):567-82. doi: 10.1002/ajmg.1320270310.

  PMID: 3631131 BACKGROUND

• Templeton AR, Boerwinkle E, Sing CF. A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila. Genetics. 1987 Oct;117(2):343-51. doi: 10.1093/genetics/117.2.343.

  PMID: 2822535 BACKGROUND

• Boerwinkle E, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. III. Simultaneous estimation of the frequencies and effects of the apolipoprotein E polymorphism and residual polygenetic effects on cholesterol, betalipoprotein and triglyceride levels. Ann Hum Genet. 1987 Jul;51(3):211-26. doi: 10.1111/j.1469-1809.1987.tb00874.x.

  PMID: 3688836 BACKGROUND

• Sing CF, Boerwinkle EA. Genetic architecture of inter-individual variability in apolipoprotein, lipoprotein and lipid phenotypes. Ciba Found Symp. 1987;130:99-127. doi: 10.1002/9780470513507.ch7.

  PMID: 3327665 BACKGROUND

• Boehnke M, Moll PP, Kottke BA, Weidman WH. Partitioning the variability of fasting plasma glucose levels in pedigrees. Genetic and environmental factors. Am J Epidemiol. 1987 Apr;125(4):679-89. doi: 10.1093/oxfordjournals.aje.a114581.

  PMID: 3826046 BACKGROUND

• Sing CF et al: Characterization of Genes Affecting Quantitative Traits in Humans. Proceedings Second International Conference on Quantitative Genetics, B. Weir (Ed.) Sinauer. In press, 1987

  BACKGROUND

• Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988 Jan-Feb;8(1):1-21. doi: 10.1161/01.atv.8.1.1.

  PMID: 3277611 BACKGROUND

• Lavie CJ, Gau GT, Squires RW, Kottke BA. Management of lipids in primary and secondary prevention of cardiovascular diseases. Mayo Clin Proc. 1988 Jun;63(6):605-21. doi: 10.1016/s0025-6196(12)64891-5.

  PMID: 3287024 BACKGROUND

• Moll PP, Michels VV, Weidman WH, Kottke BA. Genetic determination of plasma apolipoprotein AI in a population-based sample. Am J Hum Genet. 1989 Jan;44(1):124-39.

  PMID: 2491774 BACKGROUND

• Kaprio J, Ferrell RE, Kottke BA, Sing CF. Smoking and reverse cholesterol transport: evidence for gene-environment interaction. Clin Genet. 1989 Oct;36(4):266-8. doi: 10.1111/j.1399-0004.1989.tb03201.x. No abstract available.

  PMID: 2509115 BACKGROUND

• Boehnke M, Moll PP. Identifying pedigrees segregating at a major locus for a quantitative trait: an efficient strategy for linkage analysis. Am J Hum Genet. 1989 Feb;44(2):216-24.

  PMID: 2912068 BACKGROUND

• Turner ST, Weidman WH, Michels VV, Reed TJ, Ormson CL, Fuller T, Sing CF. Distribution of sodium-lithium countertransport and blood pressure in Caucasians five to eighty-nine years of age. Hypertension. 1989 Apr;13(4):378-91. doi: 10.1161/01.hyp.13.4.378.

  PMID: 2925236 BACKGROUND

• Hasstedt SJ, Moll PP. Estimation of genetic model parameters: variables correlated with a quantitative phenotype exhibiting major locus inheritance. Genet Epidemiol. 1989;6(2):319-32. doi: 10.1002/gepi.1370060203.

  PMID: 2721927 BACKGROUND

• Carlson TL, Kottke BA. Effect of 25-hydroxycholesterol and bile acids on the regulation of cholesterol metabolism in Hep G2 cells. Biochem J. 1989 Nov 15;264(1):241-7. doi: 10.1042/bj2640241.

  PMID: 2513806 BACKGROUND

• Kottke BA, Friedlaender JS, Zerba KE, Sing CF. Lipid and apolipoprotein levels in six Solomon Island societies differ from those in a U.S. white population. Am J Phys Anthropol. 1990 Apr;81(4):483-91. doi: 10.1002/ajpa.1330810405.

  PMID: 2110417 BACKGROUND

• Reilly SL, Kottke BA, Sing CF. The effects of generation and gender on the joint distributions of lipid and apolipoprotein phenotypes in the population at large. J Clin Epidemiol. 1990;43(9):921-40. doi: 10.1016/0895-4356(90)90076-2.

  PMID: 2213081 BACKGROUND

• Sing CF, Haviland MB, Zerba KE, Templeton AR. Application of cladistics to the analysis of genotype-phenotype relationships. Eur J Epidemiol. 1992 May;8 Suppl 1:3-9. doi: 10.1007/BF00145343.

  PMID: 1354623 BACKGROUND

• Reilly SL, Ferrell RE, Kottke BA, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants. Am J Hum Genet. 1992 Dec;51(6):1311-24.

  PMID: 1463013 BACKGROUND

• Hallaway BJ, Rastogi A, Kottke BA. Apolipoprotein B quantified by particle-concentration fluorescence immunoassay. Clin Chem. 1992 Dec;38(12):2387-91.

  PMID: 1458572 BACKGROUND

• Turner ST, Rebbeck TR, Sing CF. Sodium-lithium countertransport and probability of hypertension in Caucasians 47 to 89 years old. Hypertension. 1992 Dec;20(6):841-50. doi: 10.1161/01.hyp.20.6.841.

  PMID: 1452301 BACKGROUND

• Sing CF, Moll PP. Genetics of atherosclerosis. Annu Rev Genet. 1990;24:171-87. doi: 10.1146/annurev.ge.24.120190.001131. No abstract available.

  PMID: 2088166 BACKGROUND

MeSH Terms

Conditions

Atherosclerosis; Cardiovascular Diseases; Heart Diseases; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Coronary Disease; Myocardial Ischemia

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: September 1, 1979
• Study Completion: June 1, 1991
• Last Updated: May 13, 2016

Record last verified: 2000-04