NCT00005393|Completed
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Sponsor study identifier
observational
5,115
0 countries
N/A
Study Start
August 1996
Actual (reported)Primary Completion
December 31, 2021
Actual (reported)Study Completion
December 31, 2021
Actual (reported)To measure serum concentrations of alpha tocopherol, selenium and all major carotenoids (alpha- and beta- carotene, lutein, (beta-cryptoxanthin and lycopene) in Black and white, male and female, high and low education individuals aged 18-30 in 1985-86. In subsequent renewals additional markers of oxidative stress and endothelial dysfunction have been measured in blood collected 7 to 30 years after baseline.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2021
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 1996
Actual (reported)May 25, 2000
Actual (reported)May 26, 2000
Actual (reported)December 31, 2021
Actual (reported)December 31, 2021
Actual (reported)Clinical cardiovascular disease
Events are ascertained in annual direct contact with the participant. Medical records are obtained and adjudicated for event status.
Annual participant contact
subclinical cardiovascular disease
every 5 years
The study sample was selected from residents of Minneapolis, MN, Birmingham, AL, Chicago, IL and Oakland, CA in 1985-86 as a community based sample.
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, Steffes M. Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2003 Aug;49(8):1358-66. doi: 10.1373/49.8.1358.
Svilaas A, Sakhi AK, Andersen LF, Svilaas T, Strom EC, Jacobs DR Jr, Ose L, Blomhoff R. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr. 2004 Mar;134(3):562-7. doi: 10.1093/jn/134.3.562.
blood and urine samples and DNA
David R Jacobs, PhD
University of Minnesota
Myron D Gross, PhD
University of Minnesota
5,115 participants (actual enrollment reported by the registry).
First Submitted
May 25, 2000
First Posted
May 26, 2000
Study Start
August 1996
Actual (reported)Lee DH, Gross MD, Jacobs DR Jr; Cardiovascular Risk Development in Young Adults Study. Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2004 Mar;50(3):582-8. doi: 10.1373/clinchem.2003.028852. Epub 2004 Jan 15.
Lee DH, Jacobs DR Jr, Gross M, Steffes M. Serum gamma-glutamyltransferase was differently associated with microalbuminuria by status of hypertension or diabetes: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2005 Jul;51(7):1185-91. doi: 10.1373/clinchem.2004.045872. Epub 2005 May 12.
Primary Completion
December 31, 2021
Actual (reported)Study Completion
December 31, 2021
Actual (reported)Last Updated
February 10, 2022
Record last verified: 2022-02
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Source: ClinicalTrials.gov.
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