Epidemiology: Oxidative Stress and Early Atherosclerosis

NCT00005393 | Completed

• 1 other identifier: 4299
• Study Type: observational
• Target: 5,115
• Locations: 0 countries
• Sites: N/A

Brief Summary

To measure serum concentrations of alpha tocopherol, selenium and all major carotenoids (alpha- and beta- carotene, lutein, (beta-cryptoxanthin and lycopene) in Black and white, male and female, high and low education individuals aged 18-30 in 1985-86. In subsequent renewals additional markers of oxidative stress and endothelial dysfunction have been measured in blood collected 7 to 30 years after baseline.

Conditions

Cardiovascular Diseases; Heart Diseases; Atherosclerosis; Coronary Arteriosclerosis

Outcome Measures

Primary Outcomes (1)

• Clinical cardiovascular disease

  Events are ascertained in annual direct contact with the participant. Medical records are obtained and adjudicated for event status.

  Annual participant contact

Secondary Outcomes (1)

• subclinical cardiovascular disease

  every 5 years

Eligibility Criteria

• Age: 17 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study sample was selected from residents of Minneapolis, MN, Birmingham, AL, Chicago, IL and Oakland, CA in 1985-86 as a community based sample.

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University of Minnesota: lead
• Northwestern University: collaborator
• Kaiser Permanente: collaborator
• University of Alabama at Birmingham: collaborator

Related Publications (4)

• Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, Steffes M. Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2003 Aug;49(8):1358-66. doi: 10.1373/49.8.1358.

  PMID: 12881453 BACKGROUND

• Svilaas A, Sakhi AK, Andersen LF, Svilaas T, Strom EC, Jacobs DR Jr, Ose L, Blomhoff R. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr. 2004 Mar;134(3):562-7. doi: 10.1093/jn/134.3.562.

  PMID: 14988447 BACKGROUND

• Lee DH, Gross MD, Jacobs DR Jr; Cardiovascular Risk Development in Young Adults Study. Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2004 Mar;50(3):582-8. doi: 10.1373/clinchem.2003.028852. Epub 2004 Jan 15.

  PMID: 14726472 BACKGROUND

• Lee DH, Jacobs DR Jr, Gross M, Steffes M. Serum gamma-glutamyltransferase was differently associated with microalbuminuria by status of hypertension or diabetes: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2005 Jul;51(7):1185-91. doi: 10.1373/clinchem.2004.045872. Epub 2005 May 12.

  PMID: 15890893 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

blood and urine samples and DNA

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Diseases; Atherosclerosis; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Coronary Disease; Myocardial Ischemia

Study Officials

• David R Jacobs, PhD

  University of Minnesota

  PRINCIPAL INVESTIGATOR

• Myron D Gross, PhD

  University of Minnesota

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: August 1, 1996
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: February 10, 2022

Record last verified: 2022-02