Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients

NCT00006194 | Completed

• 2 other identifiers: NCRR-M01RR00036-0764M01RR000036
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Decreased skeletal muscle mass is a prevalent condition among the elderly, and an important cause of disability and functional decline. The declines in muscle mass associated with aging may be related to alterations in specific kinds of growth factors in the muscle. Elderly hip fracture patients often have significant decreases in muscle mass. The purpose of this study is to investigate whether an exercise program can induce changes in muscle growth factors that are associated with increases in muscle mass and strength in elderly hip fracture patients.

Conditions

Hip Fractures; Muscular Atrophy

Keywords

sarcopenia

Interventions

Exercise BEHAVIORAL

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Enrollment in HSC protocol #97-0695 "Rehabilitation Intensification Post Hip Fracture"
• Community-dwelling
• Hip fracture within 16 weeks of the screening assessment for protocol 97-0695
• Persistent mobility and/or ADL impairments, but independent in ambulation
• Modified Physical Performance Test (PPT) score between 12 and 28

Sponsors & Collaborators

• National Center for Research Resources (NCRR): lead

Study Sites (1)

Washington University

St Louis, Missouri, 63110, United States

Location

Related Publications (1)

• Fairhall NJ, Dyer SM, Mak JC, Diong J, Kwok WS, Sherrington C. Interventions for improving mobility after hip fracture surgery in adults. Cochrane Database Syst Rev. 2022 Sep 7;9(9):CD001704. doi: 10.1002/14651858.CD001704.pub5.

  PMID: 36070134 DERIVED

MeSH Terms

Conditions

Hip Fractures; Muscular Atrophy; Sarcopenia

Interventions

Exercise

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: NIH

Study Record Dates

• First Submitted: September 7, 2000
• First Posted: September 8, 2000
• Last Updated: June 24, 2005

Record last verified: 2003-12

Locations

US (1)