Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

NCT04532814 | Active Not Recruiting

• 2 other identifiers: 20-002949R01DK045343
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Conditions

Upper Body Obesity

Outcome Measures

Primary Outcomes (1)

• Skeletal muscle glucose uptake

  Is exercise induced skeletal muscle glucose uptake different in obese compared to lean adults

  1 hour

Study Arms (2)

Lean

OTHER

Control

Other: Exercise

Obese

EXPERIMENTAL

Other: Exercise

Interventions

Exercise OTHER

Cycling 60% VO2 max

Lean; Obese

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• For the exercise studies of leg glucose uptake - "insulin sensitive" group:
• Sedentary, normal weight, premenopausal women.
• Sedentary, age-matched normal weight men.
• Weight stable for two (2) months prior to study.
• Willing to provide written, informed consent.
• For the exercise studies of leg glucose uptake - "insulin resistant" group:
• For the exercise studies of leg glucose uptake - "insulin resistant" group:
• Upper body obese (UBO) premenopausal women.
• Age-matched upper body obese (UBO) men.
• Weight stable for two (2) months prior to study.
• Willing to provide written, informed consent.

You may not qualify if:

• Age \< 18 or \> 55 years (premenopausal women and age-matched men).
• Use of glucose-lowering agents.
• For female subjects: positive pregnancy test at the time of enrollment or study
• History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
• Active systemic illness or malignancy.
• Symptomatic macrovascular or microvascular disease.

Sponsors & Collaborators

• Mayo Clinic: lead
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): collaborator

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location

Related Links

• Mayo Clinic Clinical Trials

MeSH Terms

Conditions

Obesity, Abdominal

Interventions

Exercise

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Michael D Jensen, MD

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: This study is aimed to determine whether obesity effects muscle glucose utilization during exercise.

Study Record Dates

• First Submitted: August 27, 2020
• First Posted: August 31, 2020
• Study Start: September 6, 2020
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): May 31, 2027
• Last Updated: September 15, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)