Nutrient Sensing & Signaling in Aging Muscle

NCT02999802 | Completed DMC

• 2 other identifiers: 15-0226R56AG051267
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

This research seeks to better understand how cellular and molecular bases of changes associated with aging contribute to decreased function and increased incidence of disease. Specific mechanism in muscle responsible for anabolic resistance - a key component of sarcopenia and frailty - will be identified. The proposed research is relevant to public health because the discovery of new targets for interventions and novel therapeutics to improve muscle strength and function, prevent falls, and reduce physical dependency will improve the healthspan and quality of life in older adults by improving their physical function and ability to remain independent and healthy for a longer period of time.

Conditions

Nutrient Sensing

Keywords

Nutrient Sensing; Exercise; Elderly

Outcome Measures

Primary Outcomes (1)

• Change in muscle protein synthesis in response to amino acids

  Measurement of the change in muscle protein synthesis in response to amino acids by standard stable isotope method

  Change from baseline to 3 months

Secondary Outcomes (2)

• Muscle mass

  Change from baseline to 3 months

• Muscle function

  Change from baseline to 3 months

Study Arms (1)

Exercise

EXPERIMENTAL

Determining the effect of 12 weeks of resistance training exercise on the response of muscle amino acid sensing

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

Progressive resistance exercise training

Exercise

Eligibility Criteria

• Age: 65 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• yrs
• Stable body weight for at least 1 year
• Ability to sign consent form:

You may not qualify if:

• Exercise training (\>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
• Physical dependence or frailty (impairment in the Activities of Daily Living (ADL), history of falls (\>2/year), or \>5% weight loss in the past year)
• Significant heart, liver, kidney, blood, or respiratory disease
• Peripheral vascular disease
• Diabetes mellitus or other untreated endocrine disease
• Active cancer
• Acute infectious disease or history of chronic infections
• Recent (within 3 months) treatment with anabolic steroids, or prolonged systemic corticosteroids.
• Alcohol or drug abuse
• Tobacco use (smoking or chewing)
• Malnutrition (BMI \< 18.5 kg/sq meter)
• Obesity (BMI \> 30 kg/sq meter)

Sponsors & Collaborators

• The University of Texas Medical Branch, Galveston: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

UTMB

Galveston, Texas, 77555, United States

Location

Related Publications (1)

• Moro T, Brightwell CR, Deer RR, Graber TG, Galvan E, Fry CS, Volpi E, Rasmussen BB. Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training. J Nutr. 2018 Jun 1;148(6):900-909. doi: 10.1093/jn/nxy064.

  PMID: 29796648 DERIVED

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Blake B Rasmussen, PhD

  University of Texas

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2016
• First Posted: December 21, 2016
• Study Start: October 1, 2015
• Primary Completion: December 21, 2016
• Study Completion: December 21, 2016
• Last Updated: June 13, 2018

Record last verified: 2017-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)