Quantitative Genetic Analysis of Lipid Research Clinic Family Data

NCT00005188 | Completed

• 2 other identifiers: 1066R01HL033973
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To assess the mode of inheritance of familial combined hyperlipidemia and familial primary hypoalphalipoproteinemia and to resolve genetic and familial environmental effects on several phenotypes of importance to coronary heart disease.

Conditions

Cardiovascular Diseases; Heart Diseases; Coronary Disease; Tangier Disease; Atherosclerosis

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (24)

• Rao DC, Wette R. Nonrandom sampling in genetic epidemiology: maximum likelihood methods for multifactorial analysis of quantitative data ascertained through truncation. Genet Epidemiol. 1987;4(5):357-76. doi: 10.1002/gepi.1370040505.

  PMID: 3319764 BACKGROUND

• Rao DC, Vogler GP, McGue M, Russell JM. Maximum-likelihood estimation of familial correlations from multivariate quantitative data on pedigrees: a general method and examples. Am J Hum Genet. 1987 Dec;41(6):1104-16.

  PMID: 3687943 BACKGROUND

• Rao DC, Wette R, Ewens WJ. Multifactorial analysis of family data ascertained through truncation: a comparative evaluation of two methods of statistical inference. Am J Hum Genet. 1988 Mar;42(3):506-15.

  PMID: 3348215 BACKGROUND

• Wette R, McGue MK, Rao DC, Cloninger CR. On the properties of maximum likelihood estimators of familial correlations under variable sibship size. Biometrics. 1988 Sep;44(3):717-25.

  PMID: 3203127 BACKGROUND

• Province MA, Rao DC. Familial aggregation in the presence of temporal trends. Stat Med. 1988 Jan-Feb;7(1-2):185-98. doi: 10.1002/sim.4780070120.

  PMID: 3258435 BACKGROUND

• Borecki IB, Laskarzewski P, Rao DC. Genetic factors influencing apolipoprotein AI and AII levels in a kindred with premature coronary heart disease. Genet Epidemiol. 1988;5(6):393-406. doi: 10.1002/gepi.1370050604.

  PMID: 3145239 BACKGROUND

• Province MA, Tishler P, Rao DC. Repeated-measures model for the investigation of temporal trends using longitudinal family studies: application to systolic blood pressure. Genet Epidemiol. 1989;6(2):333-47. doi: 10.1002/gepi.1370060204.

  PMID: 2721928 BACKGROUND

• McGue M, Wette R, Rao DC. Path analysis under generalized marital resemblance: evaluation of the assumptions underlying the mixed homogamy model by the Monte Carlo method. Genet Epidemiol. 1989;6(2):373-88. doi: 10.1002/gepi.1370060207.

  PMID: 2721930 BACKGROUND

• Reddy BM, Rao DC. Phenylthiocarbamide taste sensitivity revisited: complete sorting test supports residual family resemblance. Genet Epidemiol. 1989;6(3):413-21. doi: 10.1002/gepi.1370060304.

  PMID: 2753351 BACKGROUND

• Rao DC, Wette R. Nonrandom sampling in genetic epidemiology: an implementation of the Hanis-Chakraborty method for multifactorial analysis. Genet Epidemiol. 1989;6(3):461-70. doi: 10.1002/gepi.1370060308.

  PMID: 2753354 BACKGROUND

• Perusse L, Rice T, Bouchard C, Vogler GP, Rao DC. Cardiovascular risk factors in a French-Canadian population: resolution of genetic and familial environmental effects on blood pressure by using extensive information on environmental correlates. Am J Hum Genet. 1989 Aug;45(2):240-51.

  PMID: 2757030 BACKGROUND

• Byard PJ, Mukherjee BN, Bhattacharya SK, Russell JM, Rao DC. Familial aggregation of blood pressure and anthropometric variables in patrilocal households. Am J Phys Anthropol. 1989 Jul;79(3):305-11. doi: 10.1002/ajpa.1330790306.

  PMID: 2764083 BACKGROUND

• McGue M, Gerrard JW, Lebowitz MD, Rao DC. Commingling in the distributions of immunoglobulin levels. Hum Hered. 1989;39(4):196-201. doi: 10.1159/000153860.

  PMID: 2583731 BACKGROUND

• Rao DC, Wette R. Environmental index in genetic epidemiology: an investigation of its role, adequacy, and limitations. Am J Hum Genet. 1990 Jan;46(1):168-78.

  PMID: 2294748 BACKGROUND

• Vogler GP, Wette R, Laskarzewski PM, Perry TS, Rice T, Province MA, Rao DC. Heterogeneity in the biological and cultural determinants of high-density lipoprotein cholesterol in five North American populations: the Lipid Research Clinics Family Study. Hum Hered. 1989;39(5):249-57. doi: 10.1159/000153868.

  PMID: 2613250 BACKGROUND

• Rice T, Vogler GP, Perry TS, Laskarzewski PM, Province MA, Rao DC. Heterogeneity in the familial aggregation of fasting serum uric acid level in five North American populations: the Lipid Research Clinics Family Study. Am J Med Genet. 1990 Jun;36(2):219-25. doi: 10.1002/ajmg.1320360216.

  PMID: 2368810 BACKGROUND

• Rice T, Vogler GP, Perry TS, Laskarzewski PM, Province MA, Rao DC. Heterogeneity in the familial aggregation of fasting plasma glucose in five North American populations: the Lipid Research Clinics Family Study. Int J Epidemiol. 1990 Jun;19(2):290-6. doi: 10.1093/ije/19.2.290.

  PMID: 2198234 BACKGROUND

• Rice T, Laskarzewski PM, Rao DC. Commingling and complex segregation analysis of fasting plasma glucose in the Lipid Research Clinics family study. Am J Med Genet. 1992 Nov 1;44(4):399-404. doi: 10.1002/ajmg.1320440402.

  PMID: 1442875 BACKGROUND

• Rice T, Laskarzewski PM, Perry TS, Rao DC. Commingling and segregation analysis of serum uric acid in five North American populations: the Lipid Research Clinics family study. Hum Genet. 1992 Sep-Oct;90(1-2):133-8. doi: 10.1007/BF00210757.

  PMID: 1427769 BACKGROUND

• Rice T, Vogler GP, Laskarzewski PM, Perry TS, Rao DC. Familial aggregation of lipids and lipoproteins in families ascertained through random and nonrandom probands in the Minnesota Lipid Research Clinic Family Study. Hum Biol. 1991 Aug;63(4):419-39.

  PMID: 1889794 BACKGROUND

• Rice T, Vogler GP, Laskarzewski PM, Perry TS, Rao DC. Familial aggregation of lipids and lipoproteins in families ascertained through random and nonrandom probands in the Stanford Lipid Research Clinics Family Study. Am J Med Genet. 1991 Jun 1;39(3):270-7. doi: 10.1002/ajmg.1320390306.

  PMID: 1867276 BACKGROUND

• Rice T, Vogler GP, Perry TS, Laskarzewski PM, Rao DC. Familial aggregation of lipids and lipoproteins in families ascertained through random and nonrandom probands in the Iowa Lipid Research Clinics family study. Hum Hered. 1991;41(2):107-21. doi: 10.1159/000153987.

  PMID: 1855782 BACKGROUND

• Borecki IB, Rao DC, Yaouanq J, Lalouel JM. Serum ferritin as a marker of affection for genetic hemochromatosis. Hum Hered. 1990;40(3):159-66. doi: 10.1159/000153924.

  PMID: 2365376 BACKGROUND

• Vogler GP, Wette R, McGue MK, Rao DC. Properties of alternative estimators of familial correlations under variable sibship size. Biometrics. 1995 Mar;51(1):276-83.

  PMID: 7766782 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Diseases; Coronary Disease; Tangier Disease; Atherosclerosis

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Vascular Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Hypoalphalipoproteinemias; Hypolipoproteinemias; Lipid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dyslipidemias; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Arteriosclerosis; Arterial Occlusive Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: July 1, 1986
• Study Completion: June 1, 1991
• Last Updated: May 13, 2016

Record last verified: 2004-08