NCT00005545

Brief Summary

To determine if risk factors measured in childhood can predict the development of atherosclerotic coronary and carotid artery disease in adulthood.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
600

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Dec 1998

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 1998

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
8.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2009

Completed
Last Updated

December 12, 2013

Status Verified

December 1, 2013

Enrollment Period

10.4 years

First QC Date

May 25, 2000

Last Update Submit

December 10, 2013

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary ArteriosclerosisCarotid Artery Diseases

Outcome Measures

Primary Outcomes (1)

  • Flow-mediated dilatation

    1999 to 2008

Eligibility Criteria

Age35 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Muscatine Study Longitudinal Adult Cohort - representative sample of childhood participants from the 1970s

Participated in at least on school survey examination, at least one young-adult follow-up survey examination and the first Longitudinal Adult Cohort examination

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (1)

  • Tschirren J, Lauer RM, Sonka M. Automated analysis of Doppler ultrasound velocity flow diagrams. IEEE Trans Med Imaging. 2001 Dec;20(12):1422-5. doi: 10.1109/42.974936.

    PMID: 11811841BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Stored plasma and DNA samples

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary Artery DiseaseCarotid Artery Diseases

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Study Officials

  • Ronald Lauer

    University of Iowa

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

December 1, 1998

Primary Completion

May 1, 2009

Study Completion

May 1, 2009

Last Updated

December 12, 2013

Record last verified: 2013-12