NCT00005372

Brief Summary

To investigate the role of serum and dietary antioxidants, serum pro-oxidants, and smoking on the progression/regression of carotid intima-media thickness (IMT).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jan 1994

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1994

Completed
6.4 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
4.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2005

Completed
Last Updated

January 20, 2016

Status Verified

January 1, 2016

First QC Date

May 25, 2000

Last Update Submit

January 15, 2016

Conditions

AtherosclerosisCardiovascular DiseasesHeart Diseases

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (11)

  • Dwyer JH. Exposure to environmental tobacco smoke and coronary risk. Circulation. 1997 Sep 2;96(5):1367-9. No abstract available.

    PMID: 9315516BACKGROUND

  • Dwyer JH, Sun P, Kwong-Fu H, Dwyer KM, Selzer RH. Automated intima-media thickness: the Los Angeles Atherosclerosis Study. Ultrasound Med Biol. 1998 Sep;24(7):981-7. doi: 10.1016/s0301-5629(98)00069-6.

    PMID: 9809632BACKGROUND

  • Nordstrom CK, Dwyer KM, Merz CN, Shircore A, Dwyer JH. Work-related stress and early atherosclerosis. Epidemiology. 2001 Mar;12(2):180-5. doi: 10.1097/00001648-200103000-00009.

    PMID: 11246578BACKGROUND

  • Sun P, Dwyer KM, Merz CN, Sun W, Johnson CA, Shircore AM, Dwyer JH. Blood pressure, LDL cholesterol, and intima-media thickness: a test of the "response to injury" hypothesis of atherosclerosis. Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):2005-10. doi: 10.1161/01.atv.20.8.2005.

    PMID: 10938024BACKGROUND

  • Dwyer KM, Nordstrom CK, Bairey Merz CN, Dwyer JH. Carotid wall thickness and years since bilateral oophorectomy: the Los Angeles Atherosclerosis Study. Am J Epidemiol. 2002 Sep 1;156(5):438-44. doi: 10.1093/aje/kwf051.

    PMID: 12196313BACKGROUND

  • Bairey Merz CN, Dwyer J, Nordstrom CK, Walton KG, Salerno JW, Schneider RH. Psychosocial stress and cardiovascular disease: pathophysiological links. Behav Med. 2002 Winter;27(4):141-7. doi: 10.1080/08964280209596039.

    PMID: 12165968BACKGROUND

  • Nordstrom CK, Dwyer KM, Merz CN, Shircore A, Dwyer JH. Leisure time physical activity and early atherosclerosis: the Los Angeles Atherosclerosis Study. Am J Med. 2003 Jul;115(1):19-25. doi: 10.1016/s0002-9343(03)00242-0.

    PMID: 12867230BACKGROUND

  • Dwyer JH, Navab M, Dwyer KM, Hassan K, Sun P, Shircore A, Hama-Levy S, Hough G, Wang X, Drake T, Merz CN, Fogelman AM. Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study. Circulation. 2001 Jun 19;103(24):2922-7. doi: 10.1161/01.cir.103.24.2922.

    PMID: 11413081BACKGROUND

  • Dwyer JH, Allayee H, Dwyer KM, Fan J, Wu H, Mar R, Lusis AJ, Mehrabian M. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med. 2004 Jan 1;350(1):29-37. doi: 10.1056/NEJMoa025079.

    PMID: 14702425BACKGROUND

  • Wu H, Dwyer KM, Fan Z, Shircore A, Fan J, Dwyer JH. Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study. Am J Clin Nutr. 2003 Dec;78(6):1085-91. doi: 10.1093/ajcn/78.6.1085.

    PMID: 14668268BACKGROUND

  • Burcelin R, Eddouks M, Kande J, Assan R, Girard J. Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats. Biochem J. 1992 Dec 1;288 ( Pt 2)(Pt 2):675-9. doi: 10.1042/bj2880675.

    PMID: 1463468BACKGROUND

MeSH Terms

Conditions

AtherosclerosisCardiovascular DiseasesHeart Diseases

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • James Dwyer

    University of Southern California

Study Design

Study Type
observational
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

January 1, 1994

Study Completion

February 1, 2005

Last Updated

January 20, 2016

Record last verified: 2016-01