Insulin and Biogenic Amines in Cardiovascular Disease

NCT00005194 | Completed

• 2 other identifiers: 1073R01HL037871
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine the role played by insulin and biogenic amines in obesity-related hypertension and cardiovascular disease.

Conditions

Cardiovascular Diseases; Hypertension; Heart Diseases; Obesity; Myocardial Infarction; Insulin Resistance

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (32)

• Landsberg L. Diet, obesity and hypertension: an hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis. Q J Med. 1986 Dec;61(236):1081-90. No abstract available.

  PMID: 3310065 BACKGROUND

• Landsberg L. Insulin and hypertension: lessons from obesity. N Engl J Med. 1987 Aug 6;317(6):378-9. doi: 10.1056/NEJM198708063170609. No abstract available.

  PMID: 3299098 BACKGROUND

• Krieger DR, Landsberg L. Mechanisms in obesity-related hypertension: role of insulin and catecholamines. Am J Hypertens. 1988 Jan;1(1):84-90. doi: 10.1093/ajh/1.1.84.

  PMID: 3285861 BACKGROUND

• Landsberg L, Krieger DR. Obesity, metabolism, and the sympathetic nervous system. Am J Hypertens. 1989 Mar;2(3 Pt 2):125S-132S. doi: 10.1093/ajh/2.3.125s.

  PMID: 2647103 BACKGROUND

• Landsberg L. Obesity, metabolism, and hypertension. Yale J Biol Med. 1989 Sep-Oct;62(5):511-9.

  PMID: 2697985 BACKGROUND

• Troisi RJ, Weiss ST, Segal MR, Cassano PA, Vokonas PS, Landsberg L. The relationship of body fat distribution to blood pressure in normotensive men: the normative aging study. Int J Obes. 1990 Jun;14(6):515-25.

  PMID: 2401588 BACKGROUND

• Landsberg L. Insulin resistance, energy balance and sympathetic nervous system activity. Clin Exp Hypertens A. 1990;12(5):817-30. doi: 10.3109/10641969009073502.

  PMID: 2208753 BACKGROUND

• Landsberg L. The sympathoadrenal system, obesity and hypertension: an overview. J Neurosci Methods. 1990 Sep;34(1-3):179-86. doi: 10.1016/0165-0270(90)90056-l.

  PMID: 2259240 BACKGROUND

• Sparrow D, O'Connor GT, Young JB, Rosner B, Weiss ST. Relationship of urinary serotonin excretion to cigarette smoking and respiratory symptoms. The Normative Aging Study. Chest. 1992 Apr;101(4):976-80. doi: 10.1378/chest.101.4.976.

  PMID: 1372851 BACKGROUND

• Cassano PA, Rosner B, Vokonas PS, Weiss ST. Obesity and body fat distribution in relation to the incidence of non-insulin-dependent diabetes mellitus. A prospective cohort study of men in the normative aging study. Am J Epidemiol. 1992 Dec 15;136(12):1474-86. doi: 10.1093/oxfordjournals.aje.a116468.

  PMID: 1288277 BACKGROUND

• Hu H, Sparrow D, Weiss S. Association of serum albumin with blood pressure in the normative aging study. Am J Epidemiol. 1992 Dec 15;136(12):1465-73. doi: 10.1093/oxfordjournals.aje.a116467.

  PMID: 1288276 BACKGROUND

• Troisi R, Willett WC, Weiss ST. Trans-fatty acid intake in relation to serum lipid concentrations in adult men. Am J Clin Nutr. 1992 Dec;56(6):1019-24. doi: 10.1093/ajcn/56.6.1019.

  PMID: 1442652 BACKGROUND

• Young JB, Troisi RJ, Weiss ST, Parker DR, Sparrow D, Landsberg L. Relationship of catecholamine excretion to body size, obesity, and nutrient intake in middle-aged and elderly men. Am J Clin Nutr. 1992 Nov;56(5):827-34. doi: 10.1093/ajcn/56.5.827.

  PMID: 1415000 BACKGROUND

• Landsberg L, Troisi R, Parker D, Young JB, Weiss ST. Obesity, blood pressure, and the sympathetic nervous system. Ann Epidemiol. 1991 May;1(4):295-303. doi: 10.1016/1047-2797(91)90040-j.

  PMID: 1669511 BACKGROUND

• Cassano PA, Segal MR, Vokonas PS, Weiss ST. Body fat distribution, blood pressure, and hypertension. A prospective cohort study of men in the normative aging study. Ann Epidemiol. 1990 Oct;1(1):33-48. doi: 10.1016/1047-2797(90)90017-m.

  PMID: 1669488 BACKGROUND

• Troisi RJ, Heinold JW, Vokonas PS, Weiss ST. Cigarette smoking, dietary intake, and physical activity: effects on body fat distribution--the Normative Aging Study. Am J Clin Nutr. 1991 May;53(5):1104-11. doi: 10.1093/ajcn/53.5.1104.

  PMID: 1850574 BACKGROUND

• Troisi RJ, Weiss ST, Parker DR, Sparrow D, Young JB, Landsberg L. Relation of obesity and diet to sympathetic nervous system activity. Hypertension. 1991 May;17(5):669-77. doi: 10.1161/01.hyp.17.5.669.

  PMID: 2022410 BACKGROUND

• Landsberg L. Obesity-related hypertension and the insulin resistance syndrome. Trans Am Clin Climatol Assoc. 1995;106:69-75; discussion 75-6. No abstract available.

  PMID: 7483180 BACKGROUND

• Landsberg L. Pathophysiology of obesity-related hypertension: role of insulin and the sympathetic nervous system. J Cardiovasc Pharmacol. 1994;23 Suppl 1:S1-8.

  PMID: 7519690 BACKGROUND

• Payton M, Hu H, Sparrow D, Weiss ST. Low-level lead exposure and renal function in the Normative Aging Study. Am J Epidemiol. 1994 Nov 1;140(9):821-9. doi: 10.1093/oxfordjournals.aje.a117330.

  PMID: 7977292 BACKGROUND

• Ward KD, Sparrow D, Vokonas PS, Willett WC, Landsberg L, Weiss ST. The relationships of abdominal obesity, hyperinsulinemia and saturated fat intake to serum lipid levels: the Normative Aging Study. Int J Obes Relat Metab Disord. 1994 Mar;18(3):137-44.

  PMID: 8186810 BACKGROUND

• Ward KD, Sparrow D, Landsberg L, Young JB, Vokonas PS, Weiss ST. The relationship of epinephrine excretion to serum lipid levels: the Normative Aging Study. Metabolism. 1994 Apr;43(4):509-13. doi: 10.1016/0026-0495(94)90085-x.

  PMID: 8159112 BACKGROUND

• Payton M, Hu H, Sparrow D, Young JB, Landsberg L, Weiss ST. Relation between blood lead and urinary biogenic amines in community-exposed men. Am J Epidemiol. 1993 Nov 15;138(10):815-25. doi: 10.1093/oxfordjournals.aje.a116785.

  PMID: 8237970 BACKGROUND

• Landsberg L, Young JB. Sympathoadrenal activity and obesity: physiological rationale for the use of adrenergic thermogenic drugs. Int J Obes Relat Metab Disord. 1993 Feb;17 Suppl 1:S29-34.

  PMID: 8384176 BACKGROUND

• Parker DR, Weiss ST, Troisi R, Cassano PA, Vokonas PS, Landsberg L. Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study. Am J Clin Nutr. 1993 Aug;58(2):129-36. doi: 10.1093/ajcn/58.2.129.

  PMID: 8338037 BACKGROUND

• Young JB, Macdonald IA. Sympathoadrenal activity in human obesity: heterogeneity of findings since 1980. Int J Obes Relat Metab Disord. 1992 Dec;16(12):959-67.

  PMID: 1335975 BACKGROUND

• Landsberg L. Obesity and hypertension: experimental data. J Hypertens Suppl. 1992 Dec;10(7):S195-201.

  PMID: 1291654 BACKGROUND

• Landsberg L. Hyperinsulinemia: possible role in obesity-induced hypertension. Hypertension. 1992 Jan;19(1 Suppl):I61-6. doi: 10.1161/01.hyp.19.1_suppl.i61.

  PMID: 1730456 BACKGROUND

• Daly PA, Landsberg L. Pathogenesis of hypertension in NIDDM: lessons from obesity. J Hum Hypertens. 1991 Aug;5(4):277-85. No abstract available.

  PMID: 1956026 BACKGROUND

• Daly PA, Landsberg L. Hypertension in obesity and NIDDM. Role of insulin and sympathetic nervous system. Diabetes Care. 1991 Mar;14(3):240-8. doi: 10.2337/diacare.14.3.240.

  PMID: 2044439 BACKGROUND

• Manning WJ, Shannon RP, Santinga JA, Parker JA, Gervino EV, Come PC, Wei JY. Reversal of changes in left ventricular diastolic filling associated with normal aging using diltiazem. Am J Cardiol. 1991 Apr 15;67(9):894-6. doi: 10.1016/0002-9149(91)90628-x. No abstract available.

  PMID: 2011992 BACKGROUND

• Lipsitz LA, Jonsson PV, Marks BL, Parker JA, Royal HD, Wei JY. Reduced supine cardiac volumes and diastolic filling rates in elderly patients with chronic medical conditions. Implications for postural blood pressure homeostasis. J Am Geriatr Soc. 1990 Feb;38(2):103-7. doi: 10.1111/j.1532-5415.1990.tb03469.x.

  PMID: 2299113 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Hypertension; Heart Diseases; Obesity; Myocardial Infarction; Insulin Resistance

Condition Hierarchy (Ancestors)

Vascular Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Myocardial Ischemia; Infarction; Ischemia; Pathologic Processes; Necrosis; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: September 1, 1986
• Study Completion: August 1, 1991
• Last Updated: February 18, 2016

Record last verified: 2000-06