Hypertension in Blacks of West African Origin
2 other identifiers
observational
N/A
0 countries
N/A
Brief Summary
To continue an international collaborative study on hypertension in populations of West African origin.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Sep 1991
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 1991
CompletedFirst Submitted
Initial submission to the registry
May 25, 2000
CompletedFirst Posted
Study publicly available on registry
May 26, 2000
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2005
CompletedJuly 29, 2016
January 1, 2008
13.9 years
May 25, 2000
July 28, 2016
Conditions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Related Publications (67)
Rotimi C, Cooper R, Cao G, Sundarum C, McGee D. Familial aggregation of cardiovascular diseases in African-American pedigrees. Genet Epidemiol. 1994;11(5):397-407. doi: 10.1002/gepi.1370110502.
PMID: 7835686BACKGROUNDRotimi C, Morrison L, Cooper R, Oyejide C, Effiong E, Ladipo M, Osotemihen B, Ward R. Angiotensinogen gene in human hypertension. Lack of an association of the 235T allele among African Americans. Hypertension. 1994 Nov;24(5):591-4. doi: 10.1161/01.hyp.24.5.591.
PMID: 7960018BACKGROUNDCooper RS, Rotimi CN, Kaufman JS, Muna WF, Mensah GA. Hypertension treatment and control in sub-Saharan Africa: the epidemiological basis for policy. BMJ. 1998 Feb 21;316(7131):614-7. doi: 10.1136/bmj.316.7131.614. No abstract available.
PMID: 9518920BACKGROUNDLuke AH, Rotimi CN, Cooper RS, Long AE, Forrester TE, Wilks R, Bennett FI, Ogunbiyi O, Compton JA, Bowsher RR. Leptin and body composition of Nigerians, Jamaicans, and US blacks. Am J Clin Nutr. 1998 Mar;67(3):391-6. doi: 10.1093/ajcn/67.3.391.
PMID: 9497181BACKGROUNDKaufman JS, Asuzu MC, Rotimi CN, Johnson OO, Owoaje EE, Cooper RS. The absence of adult mortality data for sub-Saharan Africa: a practical solution. Bull World Health Organ. 1997;75(5):389-95.
PMID: 9447773BACKGROUNDKaufman JS, Asuzu MC, Mufunda J, Forrester T, Wilks R, Luke A, Long AE, Cooper RS. Relationship between blood pressure and body mass index in lean populations. Hypertension. 1997 Dec;30(6):1511-6. doi: 10.1161/01.hyp.30.6.1511.
PMID: 9403575BACKGROUNDKaufman JS, Durazo-Arvizu RA, Rotimi CN, McGee DL, Cooper RS. Obesity and hypertension prevalence in populations of African origin. The Investigators of the International Collaborative Study on Hypertension in Blacks. Epidemiology. 1996 Jul;7(4):398-405. doi: 10.1097/00001648-199607000-00010.
PMID: 8793366BACKGROUNDRotimi C, Luke A, Li Z, Compton J, Bowsher R, Cooper R. Heritability of plasma leptin in a population sample of African-American families. Genet Epidemiol. 1997;14(3):255-63. doi: 10.1002/(SICI)1098-2272(1997)14:33.0.CO;2-4.
PMID: 9181355BACKGROUNDRotimi CN, Cooper RS, Marcovina SM, McGee D, Owoaje E, Ladipo M. Serum distribution of lipoprotein(a) in African Americans and Nigerians: potential evidence for a genotype-environmental effect. Genet Epidemiol. 1997;14(2):157-68. doi: 10.1002/(SICI)1098-2272(1997)14:23.0.CO;2-4.
PMID: 9129961BACKGROUNDForrester T, McFarlane-Anderson N, Bennett FI, Wilks R, Cooper R, Rotimi C, Morrison L, Ward R. The angiotensin converting enzyme and blood pressure in Jamaicans. Am J Hypertens. 1997 May;10(5 Pt 1):519-24. doi: 10.1016/s0895-7061(97)00049-6.
PMID: 9160762BACKGROUNDCooper RS, Rotimi CN, Kaufman JS, Owoaje EE, Fraser H, Forrester T, Wilks R, Riste LK, Cruickshank JK. Prevalence of NIDDM among populations of the African diaspora. Diabetes Care. 1997 Mar;20(3):343-8. doi: 10.2337/diacare.20.3.343.
PMID: 9051385BACKGROUNDRotimi C, Cooper R, Ogunbiyi O, Morrison L, Ladipo M, Tewksbury D, Ward R. Hypertension, serum angiotensinogen, and molecular variants of the angiotensinogen gene among Nigerians. Circulation. 1997 May 20;95(10):2348-50. doi: 10.1161/01.cir.95.10.2348.
PMID: 9170394BACKGROUNDLuke A, Durazo-Arvizu R, Rotimi C, Prewitt TE, Forrester T, Wilks R, Ogunbiyi OJ, Schoeller DA, McGee D, Cooper RS. Relation between body mass index and body fat in black population samples from Nigeria, Jamaica, and the United States. Am J Epidemiol. 1997 Apr 1;145(7):620-8. doi: 10.1093/oxfordjournals.aje.a009159.
PMID: 9098179BACKGROUNDKaufman JS, Rotimi CN, Brieger WR, Oladokum MA, Kadiri S, Osotimehin BO, Cooper RS. The mortality risk associated with hypertension: preliminary results of a prospective study in rural Nigeria. J Hum Hypertens. 1996 Jul;10(7):461-4.
PMID: 8880560BACKGROUNDRotimi C, Cooper R. Familial resemblance for anthropometric measurements and relative fat distribution among African Americans. Int J Obes Relat Metab Disord. 1995 Dec;19(12):875-80.
PMID: 8963355BACKGROUNDFreeman V, Rotimi C, Cooper R. Hypertension prevalence, awareness, treatment, and control among African Americans in the 1990s: estimates from the Maywood Cardiovascular Survey. Am J Prev Med. 1996 May-Jun;12(3):177-85.
PMID: 8743873BACKGROUNDFreeman V, Fraser H, Forrester T, Wilks R, Cruickshank J, Rotimi C, Cooper R. A comparative study of hypertension prevalence, awareness, treatment and control rates in St Lucia, Jamaica and Barbados. J Hypertens. 1996 Apr;14(4):495-501.
PMID: 8761900BACKGROUNDForrester T, McFarlane-Anderson N, Bennet F, Wilks R, Puras A, Cooper R, Rotimi C, Durazo R, Tewksbury D, Morrison L. Angiotensinogen and blood pressure among blacks: findings from a community survey in Jamaica. J Hypertens. 1996 Mar;14(3):315-21. doi: 10.1097/00004872-199603000-00007.
PMID: 8723984BACKGROUNDAtaman SL, Cooper R, Rotimi C, McGee D, Osotimehin B, Kadiri S, Kingue S, Muna W, Fraser H, Forrester T, Wilks R. Standardization of blood pressure measurement in an international comparative study. J Clin Epidemiol. 1996 Aug;49(8):869-77. doi: 10.1016/0895-4356(96)00111-4.
PMID: 8699206BACKGROUNDKaufman JS, Owoaje EE, James SA, Rotimi CN, Cooper RS. Determinants of hypertension in West Africa: contribution of anthropometric and dietary factors to urban-rural and socioeconomic gradients. Am J Epidemiol. 1996 Jun 15;143(12):1203-18. doi: 10.1093/oxfordjournals.aje.a008708.
PMID: 8651219BACKGROUNDRotimi C, Puras A, Cooper R, McFarlane-Anderson N, Forrester T, Ogunbiyi O, Morrison L, Ward R. Polymorphisms of renin-angiotensin genes among Nigerians, Jamaicans, and African Americans. Hypertension. 1996 Mar;27(3 Pt 2):558-63. doi: 10.1161/01.hyp.27.3.558.
PMID: 8613203BACKGROUNDCooper RS, Cheng HY, Rotimi C. Basal and stimulated platelet calcium and sodium in hypertensive versus normotensive black people. J Hum Hypertens. 1995 Sep;9(9):747-52.
PMID: 8551489BACKGROUNDOkosun IS, Forrester TE, Rotimi CN, Osotimehin BO, Muna WF, Cooper RS. Abdominal adiposity in six populations of West African descent: prevalence and population attributable fraction of hypertension. Obes Res. 1999 Sep;7(5):453-62. doi: 10.1002/j.1550-8528.1999.tb00433.x.
PMID: 10509602BACKGROUNDKaufman JS, Owoaje EE, Rotimi CN, Cooper RS. Blood pressure change in Africa: case study from Nigeria. Hum Biol. 1999 Aug;71(4):641-57.
PMID: 10453105BACKGROUNDOkosun IS, Cooper RS, Prewitt TE, Rotimi CN. The relation of central adiposity to components of the insulin resistance syndrome in a biracial US population sample. Ethn Dis. 1999 Spring-Summer;9(2):218-29.
PMID: 10421084BACKGROUNDRotimi CN, Cooper RS, Okosun IS, Olatunbosun ST, Bella AF, Wilks R, Bennett F, Cruickshank JK, Forrester TE. Prevalence of diabetes and impaired glucose tolerance in Nigerians, Jamaicans and US blacks. Ethn Dis. 1999 Spring-Summer;9(2):190-200.
PMID: 10421081BACKGROUNDLong AE, Prewitt TE, Kaufman JS, Rotimi CN, Cooper RS, McGee DL. Weight-height relationships among eight populations of West African origin: the case against constant BMI standards. Int J Obes Relat Metab Disord. 1998 Sep;22(9):842-6. doi: 10.1038/sj.ijo.0800670.
PMID: 9756241BACKGROUNDColilla S, Rotimi C, Cooper R, Goldberg J, Cox N. Genetic inheritance of body mass index in African-American and African families. Genet Epidemiol. 2000 Apr;18(4):360-76. doi: 10.1002/(SICI)1098-2272(200004)18:43.0.CO;2-H.
PMID: 10797595BACKGROUNDKaufman JS, Tracy JA, Durazo-Arvizu RA, Cooper RS. Lifestyle, education, and prevalence of hypertension in populations of African origin. Results from the International Collaborative Study on Hypertension in Blacks. Ann Epidemiol. 1997 Jan;7(1):22-7.
PMID: 9034403BACKGROUNDRotimi CN, Cooper RS, Ataman SL, Osotimehin B, Kadiri S, Muna W, Kingue S, Fraser H, McGee D. Distribution of anthropometric variables and the prevalence of obesity in populations of west African origin: the International Collaborative Study on Hypertension in Blacks (ICSHIB). Obes Res. 1995 Sep;3 Suppl 2:95s-105s. doi: 10.1002/j.1550-8528.1995.tb00452.x.
PMID: 8581794BACKGROUNDZhu X, McKenzie CA, Forrester T, Nickerson DA, Broeckel U, Schunkert H, Doering A, Jacob HJ, Cooper RS, Rieder MJ. Localization of a small genomic region associated with elevated ACE. Am J Hum Genet. 2000 Nov;67(5):1144-53. doi: 10.1016/S0002-9297(07)62945-0. Epub 2000 Sep 19.
PMID: 11001581BACKGROUNDCooper R, Forrester T, Ogunbiyi O, Muffinda J. Angiotensinogen levels and obesity in four black populations. ICSHIB Investigators. J Hypertens. 1998 May;16(5):571-5. doi: 10.1097/00004872-199816050-00003.
PMID: 9797167BACKGROUNDLuke A, Durazo-Arvizu RA, Rotimi CN, Iams H, Schoeller DA, Adeyemo AA, Forrester TE, Wilks R, Cooper RS. Activity energy expenditure and adiposity among black adults in Nigeria and the United States. Am J Clin Nutr. 2002 Jun;75(6):1045-50. doi: 10.1093/ajcn/75.6.1045.
PMID: 12036811BACKGROUNDCollins-Schramm HE, Phillips CM, Operario DJ, Lee JS, Weber JL, Hanson RL, Knowler WC, Cooper R, Li H, Seldin MF. Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. Am J Hum Genet. 2002 Mar;70(3):737-50. doi: 10.1086/339368. Epub 2002 Feb 11.
PMID: 11845411BACKGROUNDZhu X, Bouzekri N, Southam L, Cooper RS, Adeyemo A, McKenzie CA, Luke A, Chen G, Elston RC, Ward R. Linkage and association analysis of angiotensin I-converting enzyme (ACE)-gene polymorphisms with ACE concentration and blood pressure. Am J Hum Genet. 2001 May;68(5):1139-48. doi: 10.1086/320104. Epub 2001 Mar 27.
PMID: 11283791BACKGROUNDAdeyemo AA, Prewitt TE, Luke A, Omotade OO, Rotimi CN, Brieger WR, Cooper RS. The feasibility of implementing a dietary sodium reduction intervention among free-living normotensive individuals in south west Nigeria. Ethn Dis. 2002 Spring;12(2):207-12.
PMID: 12019929BACKGROUNDAdeyemo AA, Omotade OO, Rotimi CN, Luke AH, Tayo BO, Cooper RS. Heritability of blood pressure in Nigerian families. J Hypertens. 2002 May;20(5):859-63. doi: 10.1097/00004872-200205000-00019.
PMID: 12011645BACKGROUNDLowe WL Jr, Rotimi CN, Luke A, Guo X, Zhu X, Comuzzie AG, Schuh TS, Halbach S, Kotlar TJ, Cooper RS. The beta 3-adrenergic receptor gene and obesity in a population sample of African Americans. Int J Obes Relat Metab Disord. 2001 Jan;25(1):54-60. doi: 10.1038/sj.ijo.0801487.
PMID: 11244458BACKGROUNDLuke A, Rotimi CN, Adeyemo AA, Durazo-Arvizu RA, Prewitt TE, Moragne-Kayser L, Harders R, Cooper RS. Comparability of resting energy expenditure in Nigerians and U.S. blacks. Obes Res. 2000 Aug;8(5):351-9. doi: 10.1038/oby.2000.42.
PMID: 10968726BACKGROUNDOkosun IS, Liao Y, Rotimi CN, Prewitt TE, Cooper RS. Abdominal adiposity and clustering of multiple metabolic syndrome in White, Black and Hispanic americans. Ann Epidemiol. 2000 Jul;10(5):263-70. doi: 10.1016/s1047-2797(00)00045-4.
PMID: 10942873BACKGROUNDSchork NJ, Chakravarti A, Thiel B, Fornage M, Jacob HJ, Cai R, Rotimi CN, Cooper RS, Weder AB. Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans. Am J Hypertens. 2000 Jun;13(6 Pt 1):693-8. doi: 10.1016/s0895-7061(00)00237-5.
PMID: 10912755BACKGROUNDOkosun IS, Liao Y, Rotimi CN, Dever GE, Cooper RS. Impact of birth weight on ethnic variations in subcutaneous and central adiposity in American children aged 5-11 years. A study from the Third National Health and Nutrition Examination Survey. Int J Obes Relat Metab Disord. 2000 Apr;24(4):479-84. doi: 10.1038/sj.ijo.0801182.
PMID: 10805505BACKGROUNDOkosun IS, Liao Y, Rotimi CN, Choi S, Cooper RS. Predictive values of waist circumference for dyslipidemia, type 2 diabetes and hypertension in overweight White, Black, and Hispanic American adults. J Clin Epidemiol. 2000 Apr;53(4):401-8. doi: 10.1016/s0895-4356(99)00217-6.
PMID: 10785571BACKGROUNDCollins-Schramm HE, Kittles RA, Operario DJ, Weber JL, Criswell LA, Cooper RS, Seldin MF. Markers that discriminate between European and African ancestry show limited variation within Africa. Hum Genet. 2002 Dec;111(6):566-9. doi: 10.1007/s00439-002-0818-z. Epub 2002 Sep 14.
PMID: 12436248BACKGROUNDCooper RS, Luke A, Zhu X, Kan D, Adeyemo A, Rotimi C, Bouzekri N, Ward R. Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19. Hypertension. 2002 Nov;40(5):629-33. doi: 10.1161/01.hyp.0000035708.02789.39.
PMID: 12411454BACKGROUNDCox R, Bouzekri N, Martin S, Southam L, Hugill A, Golamaully M, Cooper R, Adeyemo A, Soubrier F, Ward R, Lathrop GM, Matsuda F, Farrall M. Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides. Hum Mol Genet. 2002 Nov 1;11(23):2969-77. doi: 10.1093/hmg/11.23.2969.
PMID: 12393808BACKGROUNDSargeant LA, Bennett FI, Forrester TE, Cooper RS, Wilks RJ. Predicting incident diabetes in Jamaica: the role of anthropometry. Obes Res. 2002 Aug;10(8):792-8. doi: 10.1038/oby.2002.107.
PMID: 12181388BACKGROUNDLeman CR, Adeyemo AA, Schoeller DA, Cooper RS, Luke A. Body composition of children in south-western Nigeria: validation of bio-electrical impedance analysis. Ann Trop Paediatr. 2003 Mar;23(1):61-7. doi: 10.1179/000349803125002887.
PMID: 12648327BACKGROUNDAdeyemo A, Luke A, Cooper R, Wu X, Tayo B, Zhu X, Rotimi C, Bouzekri N, Ward R. A genome-wide scan for body mass index among Nigerian families. Obes Res. 2003 Feb;11(2):266-73. doi: 10.1038/oby.2003.40.
PMID: 12582223BACKGROUNDZhu X, Cooper RS. Linkage disequilibrium analysis of the renin-angiotensin system genes. Curr Hypertens Rep. 2003 Feb;5(1):40-6. doi: 10.1007/s11906-003-0009-x.
PMID: 12530934BACKGROUNDMendez MA, Cooper R, Wilks R, Luke A, Forrester T. Income, education, and blood pressure in adults in Jamaica, a middle-income developing country. Int J Epidemiol. 2003 Jun;32(3):400-8. doi: 10.1093/ije/dyg083.
PMID: 12777427BACKGROUNDLuke A, Wu X, Zhu X, Kan D, Su Y, Cooper R. Linkage for BMI at 3q27 region confirmed in an African-American population. Diabetes. 2003 May;52(5):1284-7. doi: 10.2337/diabetes.52.5.1284.
PMID: 12716766BACKGROUNDThiel BA, Chakravarti A, Cooper RS, Luke A, Lewis S, Lynn A, Tiwari H, Schork NJ, Weder AB. A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. Am J Hypertens. 2003 Feb;16(2):151-3. doi: 10.1016/s0895-7061(02)03246-6.
PMID: 12559684BACKGROUNDCooper RS. Gene-environment interactions and the etiology of common complex disease. Ann Intern Med. 2003 Sep 2;139(5 Pt 2):437-40. doi: 10.7326/0003-4819-139-5_part_2-200309021-00011.
PMID: 12965972BACKGROUNDBoyne MS, Sargeant LA, Bennett FI, Cooper RS, Wilks RJ, Forrester TE. Features of isolated post-challenge hyperglycaemia in Jamaican adults. West Indian Med J. 2004 Jan;53(1):7-11.
PMID: 15114886BACKGROUNDBouzekri N, Zhu X, Jiang Y, McKenzie CA, Luke A, Forrester T, Adeyemo A, Kan D, Farrall M, Anderson S, Cooper RS, Ward R. Angiotensin I-converting enzyme polymorphisms, ACE level and blood pressure among Nigerians, Jamaicans and African-Americans. Eur J Hum Genet. 2004 Jun;12(6):460-8. doi: 10.1038/sj.ejhg.5201166.
PMID: 14970846BACKGROUNDLawoyin TO, Asuzu MC, Kaufman J, Rotimi C, Johnson L, Owoaje E, Cooper R. Using verbal autopsy to identify and proportionally assign cause of death in Ibadan, southwest Nigeria. Niger Postgrad Med J. 2004 Sep;11(3):182-6.
PMID: 15505646BACKGROUNDSargeant LA, Boyne MS, Bennett FI, Forrester TE, Cooper RS, Wilks RJ. Impaired glucose regulation in adults in Jamaica: who should have the oral glucose tolerance test? Rev Panam Salud Publica. 2004 Jul;16(1):35-42. doi: 10.1590/s1020-49892004000700005.
PMID: 15333264BACKGROUNDKoivukoski L, Fisher SA, Kanninen T, Lewis CM, von Wowern F, Hunt S, Kardia SL, Levy D, Perola M, Rankinen T, Rao DC, Rice T, Thiel BA, Melander O. Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3. Hum Mol Genet. 2004 Oct 1;13(19):2325-32. doi: 10.1093/hmg/ddh237. Epub 2004 Aug 4.
PMID: 15294874BACKGROUNDFejerman L, Bouzekri N, Wu X, Adeyemo A, Luke A, Zhu X, Ward R, Cooper RS. Association between evolutionary history of angiotensinogen haplotypes and plasma levels. Hum Genet. 2004 Sep;115(4):310-8. doi: 10.1007/s00439-004-1141-7.
PMID: 15278435BACKGROUNDBoyne MS, Gaskin P, Luke A, Wilks RJ, Bennett FI, Younger N, Sargeant LA, Adeyemo AA, Cooper RS, Forrester TE. Energetic determinants of glucose tolerance status in Jamaican adults. Eur J Clin Nutr. 2004 Dec;58(12):1666-8. doi: 10.1038/sj.ejcn.1602011.
PMID: 15162140BACKGROUNDMendez MA, Wynter S, Wilks R, Forrester T. Under- and overreporting of energy is related to obesity, lifestyle factors and food group intakes in Jamaican adults. Public Health Nutr. 2004 Feb;7(1):9-19. doi: 10.1079/phn2003508.
PMID: 14972067BACKGROUNDMendez MA, Cooper RS, Luke A, Wilks R, Bennett F, Forrester T. Higher income is more strongly associated with obesity than with obesity-related metabolic disorders in Jamaican adults. Int J Obes Relat Metab Disord. 2004 Apr;28(4):543-50. doi: 10.1038/sj.ijo.0802584.
PMID: 14770191BACKGROUNDLuke A, Adeyemo A, Kramer H, Forrester T, Cooper RS. Association between blood pressure and resting energy expenditure independent of body size. Hypertension. 2004 Mar;43(3):555-60. doi: 10.1161/01.HYP.0000118020.44335.20. Epub 2004 Feb 2.
PMID: 14757780BACKGROUNDMcKenzie CA, Sinsheimer JS, Adeyemo AA, Cox RD, Southam L, Hugill A, Bouzekri N, Lathrop M, Forrester TE, Cooper RS, Ward R. SNP haplotypes in the angiotensin I-converting enzyme (ACE) gene: analysis of Nigerian family data using gamete competition models. Ann Hum Genet. 2005 Mar;69(Pt 2):227-32. doi: 10.1046/j.1529-8817.2004.00142.x.
PMID: 15720304BACKGROUNDZhu X, Fejerman L, Luke A, Adeyemo A, Cooper RS. Haplotypes produced from rare variants in the promoter and coding regions of angiotensinogen contribute to variation in angiotensinogen levels. Hum Mol Genet. 2005 Mar 1;14(5):639-43. doi: 10.1093/hmg/ddi060. Epub 2005 Jan 13.
PMID: 15649942BACKGROUNDCooper R, Rotimi C. Hypertension in blacks. Am J Hypertens. 1997 Jul;10(7 Pt 1):804-12. doi: 10.1016/s0895-7061(97)00211-2.
PMID: 9234837BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
Richard Cooper
Loyola University
Study Design
- Study Type
- observational
- Sponsor Type
- NIH
Study Record Dates
First Submitted
May 25, 2000
First Posted
May 26, 2000
Study Start
September 1, 1991
Primary Completion
August 1, 2005
Study Completion
August 1, 2005
Last Updated
July 29, 2016
Record last verified: 2008-01