NCT00005130

Brief Summary

To measure changes in coronary heart disease risk factors in cohorts of Black and White males and females 18 to 30 years of age at baseline. Also, to identify lifestyles during this age span which influence these changes in risk factors.

Trial Health

83
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5,115

participants targeted

Target at P75+ for all trials

Timeline
88mo left

Started Jan 1984

Longer than P75 for all trials

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress85%
Jan 1984Jun 2033

Study Start

First participant enrolled

January 1, 1984

Completed
16.4 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
33.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2033

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2033

Last Updated

February 2, 2026

Status Verified

January 1, 2026

Enrollment Period

49.5 years

First QC Date

May 25, 2000

Last Update Submit

January 29, 2026

Conditions

Cardiovascular DiseasesCoronary DiseaseHypertensionHeart DiseasesObesityDiabetes Mellitus

Keywords

Cardiovascular DiseaseCoronary DiseaseProspective Cohort StudyLongitudinal Observational Study

Outcome Measures

Primary Outcomes (1)

  • Cardiovascular disease

    Incident coronary heart disease (fatal or nonfatal myocardial infarction, acute coronary syndrome without myocardial infarction, coronary revascularization, coronary heart disease death), stroke, heart failure, peripheral arterial disease

    baseline (1985) through 2033

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Black and White males and females 18 to 30 years of age at baseline (1985-1986).

Age 18-30 years, males and females, Black and White, free of long-term disease or disability that would interfere substantially with any part of the examination

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (21)

  • For list of CARDIA publications, https://zenodo.org/communities/cardia-cc/records?q=&l=list&p=1&s=10&sort=newest

    BACKGROUND

  • Hascher K, Brown R, Janulis P, Slone BR, Avila GV, Lewis CE, Schreiner PJ, Bhatt AS, Engle A, Beach LB, Rivera AS. Investigating Sex Differences in the Association of Disclosure and Concealment of Sexual Minority Identity With Cardiovascular Health in the CARDIA Cohort at Year 35. Biopsychosoc Sci Med. 2026 Jan 1;88(1):89-99. doi: 10.1097/PSY.0000000000001422. Epub 2025 Aug 12.

    PMID: 40891748DERIVED

  • Hao QY, Weng J, Zeng TT, Zeng YH, Guo JB, Li SC, Chen YR, Yang PZ, Gao JW, Li ZH. Dietary branched-chain amino acids intake and coronary artery calcium progression: insights from the coronary artery risk development in young adults (CARDIA) study. Eur J Nutr. 2025 Mar 19;64(3):131. doi: 10.1007/s00394-025-03649-2.

    PMID: 40106011DERIVED

  • Gao JW, Guo Q, Weng Y, Huang ZG, Zhang HF, Wu YB, Wang JF, Zhang SL, Liu PM. Predicting the risk of coronary artery calcium progression in the general population: insights from the MESA and CARDIA studies. Clin Radiol. 2025 Jan;80:106724. doi: 10.1016/j.crad.2024.10.006. Epub 2024 Oct 16.

    PMID: 39546957DERIVED

  • Gao JW, Hao QY, Lin Y, Li ZH, Huang ZG, Bai ZQ, Zhang HF, Wu YB, Xiong ZC, You S, Wang JF, Zhang SL, Liu PM. Variability in Lipid Profiles During Young Adulthood and the Risk of Coronary Artery Calcium Incidence in Midlife: Insights From the CARDIA Study. Circ Cardiovasc Imaging. 2024 Sep;17(9):e016842. doi: 10.1161/CIRCIMAGING.123.016842. Epub 2024 Sep 13.

    PMID: 39268602DERIVED

  • Xu X, Wang Z, Huang R, Guo Y, Xiong Z, Zhuang X, Liao X. Remnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA Study. Circ Cardiovasc Imaging. 2023 Nov;16(11):e015589. doi: 10.1161/CIRCIMAGING.123.015589. Epub 2023 Nov 21.

    PMID: 37988449DERIVED

  • Nguyen HT, Vasconcellos HD, Keck K, Reis JP, Lewis CE, Sidney S, Lloyd-Jones DM, Schreiner PJ, Guallar E, Wu CO, Lima JAC, Ambale-Venkatesh B. Multivariate longitudinal data for survival analysis of cardiovascular event prediction in young adults: insights from a comparative explainable study. BMC Med Res Methodol. 2023 Jan 25;23(1):23. doi: 10.1186/s12874-023-01845-4.

    PMID: 36698064DERIVED

  • Hao QY, Gao JW, Yuan ZM, Gao M, Wang JF, Schiele F, Zhang SL, Liu PM. Remnant Cholesterol and the Risk of Coronary Artery Calcium Progression: Insights From the CARDIA and MESA Study. Circ Cardiovasc Imaging. 2022 Jul;15(7):e014116. doi: 10.1161/CIRCIMAGING.122.014116. Epub 2022 Jul 8.

    PMID: 35861979DERIVED

  • Heravi AS, Michos ED, Zhao D, Ambale-Venkatesh B, Doria De Vasconcellos H, Lloyd-Jones D, Schreiner PJ, Reis JP, Wu C, Lewis CE, Shikany JM, Sidney S, Guallar E, Ndumele CE, Ouyang P, Hoogeveen RC, Lima JAC, Vaidya D, Post WS. Oxidative Stress and Menopausal Status: The Coronary Artery Risk Development in Young Adults Cohort Study. J Womens Health (Larchmt). 2022 Jul;31(7):1057-1065. doi: 10.1089/jwh.2021.0248. Epub 2022 Jun 8.

    PMID: 35675673DERIVED

  • Gao JW, You S, Liu ZY, Hao QY, Wang JF, Vuitton DA, Zhang SL, Liu PM. Different Metabolic Phenotypes of Obesity and Risk of Coronary Artery Calcium Progression and Incident Cardiovascular Disease Events: The CARDIA Study. Arterioscler Thromb Vasc Biol. 2022 May;42(5):677-688. doi: 10.1161/ATVBAHA.122.317526. Epub 2022 Apr 7.

    PMID: 35387482DERIVED

  • Feng W, Zhang Z, Liu Y, Li Z, Guo W, Huang F, Zhang J, Chen A, Ou C, Zhang K, Chen M. Association of Chronic Respiratory Symptoms With Incident Cardiovascular Disease and All-Cause Mortality: Findings From the Coronary Artery Risk Development in Young Adults Study. Chest. 2022 Apr;161(4):1036-1045. doi: 10.1016/j.chest.2021.10.029. Epub 2021 Nov 2.

    PMID: 34740593DERIVED

  • Gao (高静伟) JW, Hao (郝卿鋆) QY, Zhang (张海峰) HF, Li (李雄志) XZ, Yuan (袁智敏) ZM, Guo (郭颖) Y, Wang (王景峰) JF, Zhang (张少玲) SL, Liu (刘品明) PM. Low-Carbohydrate Diet Score and Coronary Artery Calcium Progression: Results From the CARDIA Study. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):491-500. doi: 10.1161/ATVBAHA.120.314838. Epub 2020 Oct 29.

    PMID: 33115269DERIVED

  • Washko GR, Colangelo LA, Estepar RSJ, Ash SY, Bhatt SP, Okajima Y, Liu K, Jacobs DR Jr, Iribarren C, Thyagarajan B, Lewis CE, Kumar R, Han MK, Dransfield MT, Carnethon MR, Kalhan R. Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study. Am J Med. 2020 Feb;133(2):222-230.e11. doi: 10.1016/j.amjmed.2019.06.049. Epub 2019 Jul 29.

    PMID: 31369720DERIVED

  • Benck LR, Cuttica MJ, Colangelo LA, Sidney S, Dransfield MT, Mannino DM, Jacobs DR Jr, Lewis CE, Zhu N, Washko GR, Liu K, Carnethon MR, Kalhan R. Association between Cardiorespiratory Fitness and Lung Health from Young Adulthood to Middle Age. Am J Respir Crit Care Med. 2017 May 1;195(9):1236-1243. doi: 10.1164/rccm.201610-2089OC.

    PMID: 28248551DERIVED

  • Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth A, Rader DJ, Ford I, Sattar N, Kathiresan S. Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting. Circulation. 2017 May 30;135(22):2091-2101. doi: 10.1161/CIRCULATIONAHA.116.024436. Epub 2017 Feb 21.

    PMID: 28223407DERIVED

  • Bantle AE, Chow LS, Steffen LM, Wang Q, Hughes J, Durant NH, Ingram KH, Reis JP, Schreiner PJ. Association of Mediterranean diet and cardiorespiratory fitness with the development of pre-diabetes and diabetes: the Coronary Artery Risk Development in Young Adults (CARDIA) study. BMJ Open Diabetes Res Care. 2016 Aug 31;4(1):e000229. doi: 10.1136/bmjdrc-2016-000229. eCollection 2016.

    PMID: 27648287DERIVED

  • Kirkegaard H, Nohr EA, Rasmussen KM, Stovring H, Sorensen TI, Lewis CE, Gunderson EP. Maternal prepregnancy waist circumference and BMI in relation to gestational weight gain and breastfeeding behavior: the CARDIA study. Am J Clin Nutr. 2015 Aug;102(2):393-401. doi: 10.3945/ajcn.114.099184. Epub 2015 Jul 1.

    PMID: 26135344DERIVED

  • Shikany JM, Jacobs DR Jr, Lewis CE, Steffen LM, Sternfeld B, Carnethon MR, Richman JS. Associations between food groups, dietary patterns, and cardiorespiratory fitness in the Coronary Artery Risk Development in Young Adults study. Am J Clin Nutr. 2013 Dec;98(6):1402-9. doi: 10.3945/ajcn.113.058826. Epub 2013 Oct 2.

    PMID: 24088719DERIVED

  • Ogunyankin KO, Liu K, Lloyd-Jones DM, Colangelo LA, Gardin JM. Reference values of right ventricular end-diastolic area defined by ethnicity and gender in a young adult population: the CARDIA study. Echocardiography. 2011 Feb;28(2):142-9. doi: 10.1111/j.1540-8175.2010.01290.x. Epub 2011 Jan 7.

    PMID: 21210835DERIVED

  • Kalhan R, Tran BT, Colangelo LA, Rosenberg SR, Liu K, Thyagarajan B, Jacobs DR Jr, Smith LJ. Systemic inflammation in young adults is associated with abnormal lung function in middle age. PLoS One. 2010 Jul 2;5(7):e11431. doi: 10.1371/journal.pone.0011431.

    PMID: 20625390DERIVED

  • Bibbins-Domingo K, Pletcher MJ, Lin F, Vittinghoff E, Gardin JM, Arynchyn A, Lewis CE, Williams OD, Hulley SB. Racial differences in incident heart failure among young adults. N Engl J Med. 2009 Mar 19;360(12):1179-90. doi: 10.1056/NEJMoa0807265.

    PMID: 19297571DERIVED

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

serum, EDTA plasma, citrated plasma, urine, extracted DNA

MeSH Terms

Conditions

Cardiovascular DiseasesCoronary DiseaseHypertensionHeart DiseasesObesityDiabetes Mellitus

Condition Hierarchy (Ancestors)

Myocardial IschemiaVascular DiseasesOverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsGlucose Metabolism DisordersMetabolic DiseasesEndocrine System Diseases

Study Officials

  • Daniel T. Lackland, DrPH

    Medical University of South Carolina

    STUDY CHAIR

  • Jing Li, MD, DrPH, MS

    University of Alabama at Birmingham

    PRINCIPAL INVESTIGATOR

  • Cora E. Lewis, MD, MSPH

    University of Alabama at Birmingham

    PRINCIPAL INVESTIGATOR

  • Mercedes R Carnethon, PhD

    Northwestern University

    PRINCIPAL INVESTIGATOR

  • Ankeet S. Bhatt, MD, MBA, ScM

    Kaiser Foundation Research Institute

    PRINCIPAL INVESTIGATOR

  • Weihong J. Tang, MD, PhD

    University of Minnesota

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
NIH
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Medicine

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

January 1, 1984

Primary Completion (Estimated)

June 30, 2033

Study Completion (Estimated)

June 30, 2033

Last Updated

February 2, 2026

Record last verified: 2026-01