NCT00005130|Active Not Recruiting
Coronary Artery Risk Development in Young Adults
CARDIA
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CARDIA
Sponsor study identifier
observational
5,115
0 countries
N/A
Study Start
January 1984
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 30, 2033
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 30, 2033
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
To measure changes in coronary heart disease risk factors in cohorts of Black and White males and females 18 to 30 years of age at baseline. Also, to identify lifestyles during this age span which influence these changes in risk factors.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 30, 2033
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1984
Date type not reportedThis date has not been verified as actual or estimated.
May 25, 2000
Actual (reported)May 26, 2000
Actual (reported)June 30, 2033
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 30, 2033
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Cardiovascular disease
Incident coronary heart disease (fatal or nonfatal myocardial infarction, acute coronary syndrome without myocardial infarction, coronary revascularization, coronary heart disease death), stroke, heart failure, peripheral arterial disease
baseline (1985) through 2033
Black and White males and females 18 to 30 years of age at baseline (1985-1986).
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
For list of CARDIA publications, https://zenodo.org/communities/cardia-cc/records?q=&l=list&p=1&s=10&sort=newest
Li XZ, Xiong ZC, Wang XY, Yu JB, Zhou J, Zhong DX, Wu YZ, Zhang BW, Zhang YM, Xia G, Fan FH, Xie X, Chen J, Song J, Zhao J, Li XR, Yang B. Dietary Approaches to Stop Hypertension Score Trajectories From Early to Middle Adulthood and Coronary Artery Calcium Progression in Middle Age. J Am Heart Assoc. 2026 Aug 7:e044564. doi: 10.1161/JAHA.125.044564. Online ahead of print.
Hao QY, Li ZH, Weng J, Zhan ZB, Bai KH, Guo JB, Cui XP, Gao JW, Zeng YH. C-Reactive Protein-Triglyceride-Glucose Index and Coronary Artery Calcium Progression: A Prospective Cohort Analysis. Clin Cardiol. 2026 Apr;49(4):e70304. doi: 10.1002/clc.70304.
serum, EDTA plasma, citrated plasma, urine, extracted DNA
Daniel T. Lackland, DrPH
Medical University of South Carolina
Jing Li, MD, DrPH, MS
University of Alabama at Birmingham
Cora E. Lewis, MD, MSPH
University of Alabama at Birmingham
Mercedes R Carnethon, PhD
Northwestern University
5,115 participants (actual enrollment reported by the registry).
First Submitted
May 25, 2000
First Posted
May 26, 2000
Study Start
January 1984
Date type not reportedThis date has not been verified as actual or estimated.
Hascher K, Brown R, Janulis P, Slone BR, Avila GV, Lewis CE, Schreiner PJ, Bhatt AS, Engle A, Beach LB, Rivera AS. Investigating Sex Differences in the Association of Disclosure and Concealment of Sexual Minority Identity With Cardiovascular Health in the CARDIA Cohort at Year 35. Biopsychosoc Sci Med. 2026 Jan 1;88(1):89-99. doi: 10.1097/PSY.0000000000001422. Epub 2025 Aug 12.
Hao QY, Weng J, Zeng TT, Zeng YH, Guo JB, Li SC, Chen YR, Yang PZ, Gao JW, Li ZH. Dietary branched-chain amino acids intake and coronary artery calcium progression: insights from the coronary artery risk development in young adults (CARDIA) study. Eur J Nutr. 2025 Mar 19;64(3):131. doi: 10.1007/s00394-025-03649-2.
Gao JW, Guo Q, Weng Y, Huang ZG, Zhang HF, Wu YB, Wang JF, Zhang SL, Liu PM. Predicting the risk of coronary artery calcium progression in the general population: insights from the MESA and CARDIA studies. Clin Radiol. 2025 Jan;80:106724. doi: 10.1016/j.crad.2024.10.006. Epub 2024 Oct 16.
Gao JW, Hao QY, Lin Y, Li ZH, Huang ZG, Bai ZQ, Zhang HF, Wu YB, Xiong ZC, You S, Wang JF, Zhang SL, Liu PM. Variability in Lipid Profiles During Young Adulthood and the Risk of Coronary Artery Calcium Incidence in Midlife: Insights From the CARDIA Study. Circ Cardiovasc Imaging. 2024 Sep;17(9):e016842. doi: 10.1161/CIRCIMAGING.123.016842. Epub 2024 Sep 13.
Xu X, Wang Z, Huang R, Guo Y, Xiong Z, Zhuang X, Liao X. Remnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA Study. Circ Cardiovasc Imaging. 2023 Nov;16(11):e015589. doi: 10.1161/CIRCIMAGING.123.015589. Epub 2023 Nov 21.
Nguyen HT, Vasconcellos HD, Keck K, Reis JP, Lewis CE, Sidney S, Lloyd-Jones DM, Schreiner PJ, Guallar E, Wu CO, Lima JAC, Ambale-Venkatesh B. Multivariate longitudinal data for survival analysis of cardiovascular event prediction in young adults: insights from a comparative explainable study. BMC Med Res Methodol. 2023 Jan 25;23(1):23. doi: 10.1186/s12874-023-01845-4.
Hao QY, Gao JW, Yuan ZM, Gao M, Wang JF, Schiele F, Zhang SL, Liu PM. Remnant Cholesterol and the Risk of Coronary Artery Calcium Progression: Insights From the CARDIA and MESA Study. Circ Cardiovasc Imaging. 2022 Jul;15(7):e014116. doi: 10.1161/CIRCIMAGING.122.014116. Epub 2022 Jul 8.
Heravi AS, Michos ED, Zhao D, Ambale-Venkatesh B, Doria De Vasconcellos H, Lloyd-Jones D, Schreiner PJ, Reis JP, Wu C, Lewis CE, Shikany JM, Sidney S, Guallar E, Ndumele CE, Ouyang P, Hoogeveen RC, Lima JAC, Vaidya D, Post WS. Oxidative Stress and Menopausal Status: The Coronary Artery Risk Development in Young Adults Cohort Study. J Womens Health (Larchmt). 2022 Jul;31(7):1057-1065. doi: 10.1089/jwh.2021.0248. Epub 2022 Jun 8.
Gao JW, You S, Liu ZY, Hao QY, Wang JF, Vuitton DA, Zhang SL, Liu PM. Different Metabolic Phenotypes of Obesity and Risk of Coronary Artery Calcium Progression and Incident Cardiovascular Disease Events: The CARDIA Study. Arterioscler Thromb Vasc Biol. 2022 May;42(5):677-688. doi: 10.1161/ATVBAHA.122.317526. Epub 2022 Apr 7.
Feng W, Zhang Z, Liu Y, Li Z, Guo W, Huang F, Zhang J, Chen A, Ou C, Zhang K, Chen M. Association of Chronic Respiratory Symptoms With Incident Cardiovascular Disease and All-Cause Mortality: Findings From the Coronary Artery Risk Development in Young Adults Study. Chest. 2022 Apr;161(4):1036-1045. doi: 10.1016/j.chest.2021.10.029. Epub 2021 Nov 2.
Gao (高静伟) JW, Hao (郝卿鋆) QY, Zhang (张海峰) HF, Li (李雄志) XZ, Yuan (袁智敏) ZM, Guo (郭颖) Y, Wang (王景峰) JF, Zhang (张少玲) SL, Liu (刘品明) PM. Low-Carbohydrate Diet Score and Coronary Artery Calcium Progression: Results From the CARDIA Study. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):491-500. doi: 10.1161/ATVBAHA.120.314838. Epub 2020 Oct 29.
Washko GR, Colangelo LA, Estepar RSJ, Ash SY, Bhatt SP, Okajima Y, Liu K, Jacobs DR Jr, Iribarren C, Thyagarajan B, Lewis CE, Kumar R, Han MK, Dransfield MT, Carnethon MR, Kalhan R. Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study. Am J Med. 2020 Feb;133(2):222-230.e11. doi: 10.1016/j.amjmed.2019.06.049. Epub 2019 Jul 29.
Benck LR, Cuttica MJ, Colangelo LA, Sidney S, Dransfield MT, Mannino DM, Jacobs DR Jr, Lewis CE, Zhu N, Washko GR, Liu K, Carnethon MR, Kalhan R. Association between Cardiorespiratory Fitness and Lung Health from Young Adulthood to Middle Age. Am J Respir Crit Care Med. 2017 May 1;195(9):1236-1243. doi: 10.1164/rccm.201610-2089OC.
Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth A, Rader DJ, Ford I, Sattar N, Kathiresan S. Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting. Circulation. 2017 May 30;135(22):2091-2101. doi: 10.1161/CIRCULATIONAHA.116.024436. Epub 2017 Feb 21.
Bantle AE, Chow LS, Steffen LM, Wang Q, Hughes J, Durant NH, Ingram KH, Reis JP, Schreiner PJ. Association of Mediterranean diet and cardiorespiratory fitness with the development of pre-diabetes and diabetes: the Coronary Artery Risk Development in Young Adults (CARDIA) study. BMJ Open Diabetes Res Care. 2016 Aug 31;4(1):e000229. doi: 10.1136/bmjdrc-2016-000229. eCollection 2016.
Kirkegaard H, Nohr EA, Rasmussen KM, Stovring H, Sorensen TI, Lewis CE, Gunderson EP. Maternal prepregnancy waist circumference and BMI in relation to gestational weight gain and breastfeeding behavior: the CARDIA study. Am J Clin Nutr. 2015 Aug;102(2):393-401. doi: 10.3945/ajcn.114.099184. Epub 2015 Jul 1.
Shikany JM, Jacobs DR Jr, Lewis CE, Steffen LM, Sternfeld B, Carnethon MR, Richman JS. Associations between food groups, dietary patterns, and cardiorespiratory fitness in the Coronary Artery Risk Development in Young Adults study. Am J Clin Nutr. 2013 Dec;98(6):1402-9. doi: 10.3945/ajcn.113.058826. Epub 2013 Oct 2.
Ogunyankin KO, Liu K, Lloyd-Jones DM, Colangelo LA, Gardin JM. Reference values of right ventricular end-diastolic area defined by ethnicity and gender in a young adult population: the CARDIA study. Echocardiography. 2011 Feb;28(2):142-9. doi: 10.1111/j.1540-8175.2010.01290.x. Epub 2011 Jan 7.
Kalhan R, Tran BT, Colangelo LA, Rosenberg SR, Liu K, Thyagarajan B, Jacobs DR Jr, Smith LJ. Systemic inflammation in young adults is associated with abnormal lung function in middle age. PLoS One. 2010 Jul 2;5(7):e11431. doi: 10.1371/journal.pone.0011431.
Bibbins-Domingo K, Pletcher MJ, Lin F, Vittinghoff E, Gardin JM, Arynchyn A, Lewis CE, Williams OD, Hulley SB. Racial differences in incident heart failure among young adults. N Engl J Med. 2009 Mar 19;360(12):1179-90. doi: 10.1056/NEJMoa0807265.
Ankeet S. Bhatt, MD, MBA, ScM
Kaiser Foundation Research Institute
Weihong J. Tang, MD, PhD
University of Minnesota
Primary Completion
June 30, 2033
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 30, 2033
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
February 2, 2026
Record last verified: 2026-01
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