NCT00005124

Brief Summary

To assess genetic effects on the variation of cardiovascular and pulmonary risk factors in a cohort of 514 pairs of white male veteran twins.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jul 1969

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 1969

Completed
29.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 1998

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

March 16, 2016

Status Verified

May 1, 2000

First QC Date

May 25, 2000

Last Update Submit

March 15, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesLung DiseasesHypertensionDiabetes MellitusObesityCoronary DiseaseMyocardial Ischemia

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (3)

  • Moore SS, Mukherji P, Leung M, Vrentas CE, Mwanja MM, Dai J. Methylation at CpG sites related to growth differentiation factor-15 was not prospectively associated with cardiovascular death in discordant monozygotic twins. Sci Rep. 2022 Mar 15;12(1):4410. doi: 10.1038/s41598-022-08369-9.

    PMID: 35292700DERIVED

  • Dai J, Mukamal KJ, Krasnow RE, Swan GE, Reed T. Higher usual alcohol consumption was associated with a lower 41-y mortality risk from coronary artery disease in men independent of genetic and common environmental factors: the prospective NHLBI Twin Study. Am J Clin Nutr. 2015 Jul;102(1):31-9. doi: 10.3945/ajcn.114.106435. Epub 2015 May 6.

    PMID: 25948664DERIVED

  • Krishnan E, Lessov-Schlaggar CN, Krasnow RE, Swan GE. Nature versus nurture in gout: a twin study. Am J Med. 2012 May;125(5):499-504. doi: 10.1016/j.amjmed.2011.11.010. Epub 2012 Feb 22.

    PMID: 22365026DERIVED

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesLung DiseasesHypertensionDiabetes MellitusObesityCoronary DiseaseMyocardial Ischemia

Condition Hierarchy (Ancestors)

Respiratory Tract DiseasesVascular DiseasesGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesOverweightOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Nemat Borhani

  • Dorit Carmelli

  • Margaret Chesney

  • Joe Christian

  • Gary Friedman

  • Marshall Greenberg

  • Clarence Grimm

  • Ray Rosenman

  • Makinodan Takashi

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

July 1, 1969

Study Completion

November 1, 1998

Last Updated

March 16, 2016

Record last verified: 2000-05