NCT00005125

Brief Summary

To continue a registry of World War II veteran twins maintained by the National Academy of Sciences-National Research Council (NAS-NRC).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jul 1970

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 1970

Completed
18.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 1988

Completed
11.7 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

June 3, 2015

Status Verified

June 1, 2001

First QC Date

May 25, 2000

Last Update Submit

June 2, 2015

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary DiseaseMyocardial IschemiaObesity

Eligibility Criteria

Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (71)

  • Jablon S, Neel JV, Gershowitz H, Atkinson GF. The NAS-NRC twin panel: methods of construction of the panel, zygosity diagnosis, and proposed use. Am J Hum Genet. 1967 Mar;19(2):133-61. No abstract available.

    PMID: 6067093BACKGROUND

  • Cederlof R, Friberg L, Hrubec Z. Cardiovascular and respiratory symptoms in relation to tobacco smoking. A study on American twins. Arch Environ Health. 1969 Jun;18(6):934-40. doi: 10.1080/00039896.1969.10665517. No abstract available.

    PMID: 5770694BACKGROUND

  • Pollin W, Allen MG, Hoffer A, Stabenau JR, Hrubec Z. Psychopathology in 15,909 pairs of veteran twins: evidence for a genetic factor in the pathogenesis of schizophrenia and its relative absence in psychoneurosis. Am J Psychiatry. 1969 Nov;126(5):597-610. doi: 10.1176/ajp.126.5.597. No abstract available.

    PMID: 5352613BACKGROUND

  • Allen MG, Pollin W. Schizophrenia in twins and the diffuse ego boundary hypothesis. Am J Psychiatry. 1970 Oct;127(4):437-42. doi: 10.1176/ajp.127.4.437. No abstract available.

    PMID: 5459506BACKGROUND

  • Feinleib M, Havlik RJ, Kwiterovich PO, Tillotson J, Garrison RJ. The National Heart Institute Twin Study. Acta Genet Med Gemellol (Roma). 1970 Jan-Apr;19(1):243-7. doi: 10.1017/s1120962300025592. No abstract available.

    PMID: 5533774BACKGROUND

  • Hoeffer A, Pollin W. Schizophrenia in the NAS-NRC panel of 15,909 veteran twin pairs. Arch Gen Psychiatry. 1970 Nov;23(5):469-77. doi: 10.1001/archpsyc.1970.01750050085012. No abstract available.

    PMID: 5478575BACKGROUND

  • Reuling FH, Schwartz JT. Heritability of the effect of corticosteroids on intraocular pressure. Acta Genet Med Gemellol (Roma). 1970 Jan-Apr;19(1):264-7. doi: 10.1017/s1120962300025658. No abstract available.

    PMID: 5533775BACKGROUND

  • Stabenau JR, Pollin W, Allen MG. Twin studies in schizophrenia and neurosis. Semin Psychiatry. 1970 Feb;2(1):65-74. No abstract available.

    PMID: 5535862BACKGROUND

  • Cederlof R, Epstein FH, Friberg, et al: Twin Registries in the Study of Chronic Disease. Report of an International Symposium in San Juan, Puerto Rico, 1-4 December 1969, Acta Med Scand Suppl. 523, 1971

    BACKGROUND

  • Allen MG, Cohen S, Pollin W. Schizophrenia in veteran twins: a diagnostic review. Am J Psychiatry. 1972 Feb;128(8):939-45. doi: 10.1176/ajp.128.8.939. No abstract available.

    PMID: 4550731BACKGROUND

  • Cohen SM, Allen MG, Pollin W, Hrubec Z. Relationship of schizo-affective psychosis to manic depressive psychosis and shizophrenia. Findings in 15,909 veteran pairs. Arch Gen Psychiatry. 1972 Jun;26(6):539-46. doi: 10.1001/archpsyc.1972.01750240051008. No abstract available.

    PMID: 4554807BACKGROUND

  • Hrubec Z, Sutton ES. Smoking and health. Lancet. 1972 Oct 28;2(7783):932. doi: 10.1016/s0140-6736(72)92580-9. No abstract available.

    PMID: 4116641BACKGROUND

  • Schwartz JT, Reuling FH, Feinleib M, Garrison RJ, Collie DJ. Twin heritability study of the effect of corticosteroids on intraocular pressure. J Med Genet. 1972 Jun;9(2):137-43. doi: 10.1136/jmg.9.2.137. No abstract available.

    PMID: 5065285BACKGROUND

  • Hrubec Z. The effect of diagnostic ascertainment in twins on the assessment of the genetic factor in disease etiology. Am J Hum Genet. 1973 Jan;25(1):15-28. No abstract available.

    PMID: 4684503BACKGROUND

  • Coffee drinking and ischaemic heart-disease. Lancet. 1973 Mar 10;1(7802):548-9. No abstract available.

    PMID: 4119977BACKGROUND

  • Hrubec Z, Cederlof R, Friberg L, Horton R, Ozolins G. Respiratory symptoms in twins: effects of residence-associated air pollution, tobacco and alcohol use, and other factors. Arch Environ Health. 1973 Sep;27(3):189-95. doi: 10.1080/00039896.1973.10666350. No abstract available.

    PMID: 4722874BACKGROUND

  • Schwartz JT, Reuling FH Jr, Feinleib M, Garrison RJ, Collie DJ. Twin heritability study of the corticosteroid response. Trans Am Acad Ophthalmol Otolaryngol. 1973 Mar-Apr;77(2):OP126-36. No abstract available.

    PMID: 4738131BACKGROUND

  • Schwartz JT, Reuling FH, Feinleib M, Garrison RJ, Collie DJ. Twin study on ocular pressure after topical dexamethasone. 1. Frequency distribution of pressure response. Am J Ophthalmol. 1973 Jul;76(1):126-36. doi: 10.1016/0002-9394(73)90018-4. No abstract available.

    PMID: 4736844BACKGROUND

  • Schwartz JT, Reuling FH, Feinleib M, Garrison RJ, Collie DJ. Twin study on ocular pressure following topically applied dexamethasone. II. Inheritance of variation in pressure response. Arch Ophthalmol. 1973 Oct;90(4):281-6. doi: 10.1001/archopht.1973.01000050283006. No abstract available.

    PMID: 4795755BACKGROUND

  • Bazaral M, Orgel HA, and Hamburger RN: Genetics of IgE and Allergy: Serum IgE Levels in Twins. J Allergy Clin Immunol 54:288-304, 1974

    BACKGROUND

  • Lynfield YL. Skin diseases in twins. Arch Dermatol. 1974 Nov;110(5):722-4. No abstract available.

    PMID: 4278385BACKGROUND

  • Bohning DE, Albert RE, Lippmann M, Foster WM. Tracheobronchial particle deposition and clearance. A study of the effects of cigarette smoking in monozygotic twins. Arch Environ Health. 1975 Sep;30(9):457-62. doi: 10.1080/00039896.1975.10666750.

    PMID: 1172413BACKGROUND

  • Feinleib M, Garrison R, Borhani N, et al: Studies of Hypertension in Twins. In: Paul, Oglesby (Ed.): Epidemiology and Control of Hypertension, Second International Symposium on the Epidemiology of Hypertension, September 1974, Miami, Symposia Specialists, 1975

    BACKGROUND

  • Hrubec Z, Allen G. Letter: Methods and interpretation of twin concordance data. Am J Hum Genet. 1975 Nov;27(6):808-9. No abstract available.

    PMID: 1239193BACKGROUND

  • Ziegler DK, Hassanein RS, Harris D, Stewart R. Headache in a non-clinic twin population. Headache. 1975 Jan;14(4):213-8. doi: 10.1111/j.1526-4610.1975.hed1404213.x. No abstract available.

    PMID: 1123304BACKGROUND

  • Borhani NO, Feinleib M, Garrison RJ, Christian JC, Rosenman RH. Genetic variance in blood pressure. Acta Genet Med Gemellol (Roma). 1976;25:137-44. doi: 10.1017/s0001566000014008.

    PMID: 1036353BACKGROUND

  • Christian JC, Feinleib M, Hulley SB, Castelli WP, Fabsitz RR, Garrison RJ, Borhani NO, Rosenman RH, Wagner J. Genetics of plasma cholesterol and triglycerides: a study of adult male twins. Acta Genet Med Gemellol (Roma). 1976;25:145-9. doi: 10.1017/s000156600001401x.

    PMID: 1036354BACKGROUND

  • Feinleib M, Christian JC, Borhani NO, Rosenman R, Garrison RJ, Wagner J, Kannel WB, Hrubec Z, Schwartz JT. The National Heart and Lung Institute twin study of cardiovascular disease risk factors: organization and methodology. Acta Genet Med Gemellol (Roma). 1976;25:125-8. doi: 10.1017/s0001566000013970. No abstract available.

    PMID: 1036351BACKGROUND

  • Horn JM, Plomin R, Rosenman R. Heritability of personality traits in adult male twins. Behav Genet. 1976 Jan;6(1):17-30. doi: 10.1007/BF01065675.

    PMID: 943159BACKGROUND

  • Hrubec Z, Cederlof R, Friberg L. Background of angina pectoris: social and environmental factors in relation to smoking. Am J Epidemiol. 1976 Jan;103(1):16-29. doi: 10.1093/oxfordjournals.aje.a112201.

    PMID: 1247009BACKGROUND

  • Rosenman RH, Rahe RH, Borhani NO, Feinleib M. Heritability of personality and behavior pattern. Acta Genet Med Gemellol (Roma). 1976;25:221-4. doi: 10.1017/s0001566000014161.

    PMID: 1036367BACKGROUND

  • Taubman P: The Determinants of Earnings: Genetics, Family and Other Environments. A Study of White Male Twins. Am Economic Rev 66:858-870, 1976

    BACKGROUND

  • Taubman P. Earnings, education, genetics, and environment. J Hum Resour. 1976 Fall;11(4):447-61.

    PMID: 988067BACKGROUND

  • Behrman J, Taubman P, and Wales T: Controlling For and Measuring the Effects of Genetics and Family Environment in Equations for Schooling and Labor Market Success. In: Taubman P (Ed.): Kinometrics: Determinants of Socioeconomic Success Within and Between Families, New York, North-Holland Publishing Company, 1977

    BACKGROUND

  • Feinleib M, Garrison RJ, Fabsitz R, Christian JC, Hrubec Z, Borhani NO, Kannel WB, Rosenman R, Schwartz JT, Wagner JO. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol. 1977 Oct;106(4):284-5. doi: 10.1093/oxfordjournals.aje.a112464.

    PMID: 562066BACKGROUND

  • Havlik R, Garrison R, Fabsitz R, Feinleib M. Genetic variability of clinical chemical values. Clin Chem. 1977;23(4):659-62.

    PMID: 557378BACKGROUND

  • Bobowick AR, Kurtzke JF, Brody JA, Hrubec Z, Gillespie M. Twin study of multiple sclerosis: an epidemiologic inquiry. Neurology. 1978 Oct;28(10):978-87. doi: 10.1212/wnl.28.10.978.

    PMID: 570667BACKGROUND

  • Fabsitz RR, Garrison RJ, Feinleib M, Hjortland M. A twin analysis of dietary intake: evidence for a need to control for possible environmental differences in MZ and DZ twins. Behav Genet. 1978 Jan;8(1):15-25. doi: 10.1007/BF01067701.

    PMID: 565201BACKGROUND

  • Feinleib M, Ware JH, Garrison RJ, Borhani N, Christian JC, Rosenman R. An analysis of variance for major coronary heart disease rick factors in twins and their brothers. Prog Clin Biol Res. 1978;24 Pt C:13-9. No abstract available.

    PMID: 569315BACKGROUND

  • Hrubec Z, Neel JV. The National Academy of Sciences--National Research Council Twin Registry: ten years of operation. Prog Clin Biol Res. 1978;24 Pt B:153-72. No abstract available.

    PMID: 569304BACKGROUND

  • Rahe RH, Hervig L, Rosenman RH. Heritability of type A behavior. Psychosom Med. 1978 Oct;40(6):478-86. doi: 10.1097/00006842-197810000-00003.

    PMID: 569878BACKGROUND

  • Taubman P: What We Learn from Estimating the Genetic Contribution to Inequality in Earnings: Reply, Am Econ Rev 68:970-976, 1978

    BACKGROUND

  • Allen G, Hrubec Z. Twin concordance. A more general model. Acta Genet Med Gemellol (Roma). 1979;28(1):3-13. doi: 10.1017/s0001566000009284.

    PMID: 575693BACKGROUND

  • Anderson RE, Hill RB, and Hrubec Z: Prospects for Pathology Studies in the NAS-NRC Twin Registry. Hum Pathol 11:403, 1980

    BACKGROUND

  • Fabsitz R, Feinleib M, Hrubec Z. Weight changes in adult twins. Acta Genet Med Gemellol (Roma). 1980;29(4):273-9. doi: 10.1017/s0001566000007789.

    PMID: 7197452BACKGROUND

  • Foch TT, and McClearn GE: Genetics, Body Weight, and Obesity. In: Stunkard, AJ (Ed.): Obesity, Philadelphia, Saunders Publishing Company, pp. 48-71, 1980

    BACKGROUND

  • Havlik RJ, Garrison RJ, Fabsitz R, Feinleib M. Variability of heart rate, P-R, QRS and Q-T durations in twins. J Electrocardiol. 1980;13(1):45-8. doi: 10.1016/s0022-0736(80)80008-2.

    PMID: 7188949BACKGROUND

  • Hrubec Z, and Omenn GS: Evidence of Genetic Predisposition to Alcoholic Cirrhosis and Psychosis: Twin Concordances for Alcoholism and Its Biologic End Points by Zygosity Among Male Veterans (Abstract of paper presented at Thirty-first Annual Meeting, American Society of Human Genetics, New York, September 1980), Am J Hum Genet 32:112A, 1980

    BACKGROUND

  • Hubert HB, Fabsitz RR, Feinleib M, Brown KS. Olfactory sensitivity in humans: genetic versus environmental control. Science. 1980 May 9;208(4444):607-9. doi: 10.1126/science.7189296.

    PMID: 7189296BACKGROUND

  • Hrubec Z: Methodologic Problems in Matched-Pair Studies Using Twins. In: Gedda L, Parisi P, and Nance WE (Eds.): Twin Research 3. Proceedings of the Third International Congress on Twin Studies, June 16-20, 1980, Jerusalem, Part C. Epidemiological and Clinical Studies, Progress in Clinical and Biological Research Volume 69C, New York, Alan R. Liss, Inc., pp. 1-7, 1981

    BACKGROUND

  • Hrubec Z, Neel JV. Familial factors in early deaths: twins followed 30 years to ages 51-61 in 1978. Hum Genet. 1981;59(1):39-46. doi: 10.1007/BF00278852.

    PMID: 10819020BACKGROUND

  • Hrubec Z, Omenn GS. Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin Exp Res. 1981 Spring;5(2):207-15. doi: 10.1111/j.1530-0277.1981.tb04890.x.

    PMID: 7018299BACKGROUND

  • Hrubec Z, Neel JV. Contribution of familial factors to the occurrence of cancer before old age in twin veterans. Am J Hum Genet. 1982 Jul;34(4):658-71.

    PMID: 7201741BACKGROUND

  • Kendler KS, Robinette CD. Schizophrenia in the National Academy of Sciences-National Research Council Twin Registry: a 16-year update. Am J Psychiatry. 1983 Dec;140(12):1551-63. doi: 10.1176/ajp.140.12.1551.

    PMID: 6685980BACKGROUND

  • Kendler KS, Robinette CD. Month of birth by zygosity in the NAS-NRC twin registry. Acta Genet Med Gemellol (Roma). 1983;32(2):113-6. doi: 10.1017/s0001566000006395.

    PMID: 6650099BACKGROUND

  • Fabsitz R, Feinleib M, Hubert H. Regression analysis of data with correlated errors: an example from the NHLBI twin study. J Chronic Dis. 1985;38(2):165-70. doi: 10.1016/0021-9681(85)90089-x.

    PMID: 4038711BACKGROUND

  • Matthews KA, Rosenman RH, Dembroski TM, Harris EL, MacDougall JM. Familial resemblance in components of the type A behavior pattern: a reanalysis of the California type A twin study. Psychosom Med. 1984 Nov-Dec;46(6):512-22. doi: 10.1097/00006842-198411000-00004.

    PMID: 6542684BACKGROUND

  • Hrubec Z, Robinette CD. The study of human twins in medical research. N Engl J Med. 1984 Feb 16;310(7):435-41. doi: 10.1056/NEJM198402163100706. No abstract available.

    PMID: 6363927BACKGROUND

  • Carmelli D, Chesney MA, Ward MM, Rosenman RH. Twin similarity in cardiovascular stress response. Health Psychol. 1985;4(5):413-23. doi: 10.1037//0278-6133.4.5.413.

    PMID: 4076117BACKGROUND

  • Kalousdian S, Fabsitz R, Havlik R, Christian J, Rosenman R. Heritability of clinical chemistries in an older twin cohort: the NHLBI Twin Study. Genet Epidemiol. 1987;4(1):1-11. doi: 10.1002/gepi.1370040102.

    PMID: 3569874BACKGROUND

  • Luxenberg JS, May C, Haxby JV, Grady C, Moore A, Berg G, White BJ, Robinette D, Rapoport SI. Cerebral metabolism, anatomy, and cognition in monozygotic twins discordant for dementia of the Alzheimer type. J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):333-40. doi: 10.1136/jnnp.50.3.333.

    PMID: 3494105BACKGROUND

  • Carmelli D, Rosenman R, Chesney M, Fabsitz R, Lee M, Borhani N. Genetic heritability and shared environmental influences of type A measures in the NHLBI Twin Study. Am J Epidemiol. 1988 May;127(5):1041-52. doi: 10.1093/oxfordjournals.aje.a114880.

    PMID: 3358405BACKGROUND

  • Selby JV, Newman B, Quesenberry CP Jr, Fabsitz RR, King MC, Meaney FJ. Evidence of genetic influence on central body fat in middle-aged twins. Hum Biol. 1989 Apr;61(2):179-94.

    PMID: 2767669BACKGROUND

  • Christian JC, Carmelli D, Castelli WP, Fabsitz R, Grim CE, Meaney FJ, Norton JA Jr, Reed T, Williams CJ, Wood PD. High density lipoprotein cholesterol. A 16-year longitudinal study in aging male twins. Arteriosclerosis. 1990 Nov-Dec;10(6):1020-5. doi: 10.1161/01.atv.10.6.1020.

    PMID: 2244851BACKGROUND

  • Selby JV, Newman B, Quesenberry CP Jr, Fabsitz RR, Carmelli D, Meaney FJ, Slemenda C. Genetic and behavioral influences on body fat distribution. Int J Obes. 1990 Jul;14(7):593-602.

    PMID: 2228394BACKGROUND

  • Carmelli D, Swan GE, Robinette D, Fabsitz RR. Heritability of substance use in the NAS-NRC Twin Registry. Acta Genet Med Gemellol (Roma). 1990;39(1):91-8. doi: 10.1017/s0001566000005602.

    PMID: 2392895BACKGROUND

  • Swan GE, Carmelli D, Reed T, Harshfield GA, Fabsitz RR, Eslinger PJ. Heritability of cognitive performance in aging twins. The National Heart, Lung, and Blood Institute Twin Study. Arch Neurol. 1990 Mar;47(3):259-62. doi: 10.1001/archneur.1990.00530030025010.

    PMID: 2310310BACKGROUND

  • Reed T, Fabsitz RR, Quiroga J. Family history of ischemic heart disease with respect to mean twin-pair cholesterol and subsequent ischemic heart disease in the NHLBI twin study. Genet Epidemiol. 1990;7(5):335-47. doi: 10.1002/gepi.1370070504.

    PMID: 2253868BACKGROUND

  • Newman B, Selby JV, Quesenberry CP Jr, King MC, Friedman GD, Fabsitz RR. Nongenetic influences of obesity on other cardiovascular disease risk factors: an analysis of identical twins. Am J Public Health. 1990 Jun;80(6):675-8. doi: 10.2105/ajph.80.6.675.

    PMID: 2343948BACKGROUND

  • Havlik RJ, Fabsitz RR, Kalousdian S, Borhani NO, Christian JC. Dietary protein and blood pressure in monozygotic twins. Prev Med. 1990 Jan;19(1):31-9. doi: 10.1016/0091-7435(90)90004-4.

    PMID: 2320557BACKGROUND

  • DeCarli C, Miller BL, Swan GE, Reed T, Wolf PA, Carmelli D. Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. Arch Neurol. 2001 Apr;58(4):643-7. doi: 10.1001/archneur.58.4.643.

    PMID: 11295996BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary DiseaseMyocardial IschemiaObesity

Condition Hierarchy (Ancestors)

Vascular DiseasesOverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Zdenek Hrubec

  • Dennis Robinette

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

July 1, 1970

Study Completion

September 1, 1988

Last Updated

June 3, 2015

Record last verified: 2001-06