Specimen Collection for Individuals With Lung Disease Associated With Rheumatoid Arthritis

NCT00001884 | Completed

• 2 other identifiers: 99006899-H-0068
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown. Researchers hope to improve their understanding of the disease process involved in PF and RA by analyzing specimens collected by bronchoscopy, lung biopsy, lung transplantation, or autopsy from patients with these conditions. The purpose of this study is to collect specimens from rheumatoid arthritis patients with and without pulmonary fibrosis as well as patients with pulmonary fibrosis without associated diseases or cause (idiopathic pulmonary fibrosis).

Conditions

Pulmonary Fibrosis; Rheumatoid Arthritis

Keywords

Bronchoscopy; Idiopathic Pulmonary Fibrosis; Proteases; Fibroblast Proliferation; Reactive Proteins; Rheumatoid Arthritis; Pulmonary Fibrosis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Non-smokers (never smoked or not smoked within the previous 2 years) who are 18 years of age or older with any of the following:
• RA with PF (biopsy-proven), or
• RA-only, or
• Idiopathic PF-only (biopsy-proven), or
• Healthy research volunteers by history and indicated tests (individuals without history of chronic cardiopulmonary disorder, collagen vascular disease, or bleeding disorder) matched for age (within 5 years) and gender.

You may not qualify if:

• Individuals with any of the following:
• Forced expiratory volume in one second (FEV(1)) less than 1L.
• Inhalational exposure to fibrogenic fibers or dusts (i.e., asbestos, silica, coal, beryllium).
• Chronic cardiopulmonary disorders other than pulmonary fibrosis.
• Other collagen vascular disorders (i.e., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease).
• Non-rheumatoid arthritis.
• Viral infections associated with PF (i.e., hepatitis B, hepatitis C, human immunodeficiency virus).
• Uncorrectable bleeding diathesis.
• Pregnancy or lactation.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Study Sites (1)

Boston University

Boston, Massachusetts, 02118-2354, United States

Location

Related Publications (1)

• Michalski JP, McCombs CC, Scopelitis E, Biundo JJ Jr, Medsger TA Jr. Alpha 1-antitrypsin phenotypes, including M subtypes, in pulmonary disease associated with rheumatoid arthritis and systemic sclerosis. Arthritis Rheum. 1986 May;29(5):586-91. doi: 10.1002/art.1780290502.

  PMID: 3487321 BACKGROUND

MeSH Terms

Conditions

Pulmonary Fibrosis; Arthritis, Rheumatoid; Idiopathic Pulmonary Fibrosis

Condition Hierarchy (Ancestors)

Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: March 21, 1999
• Study Completion: December 28, 2007
• Last Updated: July 2, 2017

Record last verified: 2007-12-28

Locations

US (1)