Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis (IPF)

NCT00258544 | Active Not Recruiting DMC

• 1 other identifier: STUDY20070385
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study is investigating the way the lung is damaged in a condition called pulmonary fibrosis. Research studies will be conducted on lung tissue obtained from an open lung biopsy performed by the subject's surgeon. The identification of unique genetic markers of scarred lung may ultimately lead to new approaches to the diagnosis and treatment of pulmonary fibrosis.

Conditions

Pulmonary Fibrosis

Keywords

Lung; Fibrosis; Idiopathic; Microarray; Tissue; Biopsy

Outcome Measures

Primary Outcomes (1)

• Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis (IPF)

  Microarray gene expression analysis involves the extraction of RNA from cells, synthesizing cDNA to hydridize to a probe array of genes, scanning signal intensities, and normalizing data to analyze probe-level expression for differential genes, Other methods of analyzing differential gene expression including Bulk RN-seq, and single cell RNA-seq will allow be employed where feasible.

  The time frame is open-ended with the goal of creating a bank of samples to support an indeterminant number of well phenotypes samples for studies of IPF.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Population includes any patients seen at the Simmons Center for Interstitial Lung Disease with the possibility of having the diagnosis of Idiopathic Pulmonary Fibrosis who's physician has ordered an open Lung Biopsy. To check for the disease also known as IPF.

You may qualify if:

• years or age or older
• Diagnosis of pulmonary fibrosis
• Undergoing open lung biopsy

You may not qualify if:

• N/A

Sponsors & Collaborators

• University of Pittsburgh: lead

Study Sites (1)

University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

Location

Related Publications (1)

• Pandit KV, Corcoran D, Yousef H, Yarlagadda M, Tzouvelekis A, Gibson KF, Konishi K, Yousem SA, Singh M, Handley D, Richards T, Selman M, Watkins SC, Pardo A, Ben-Yehudah A, Bouros D, Eickelberg O, Ray P, Benos PV, Kaminski N. Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2010 Jul 15;182(2):220-9. doi: 10.1164/rccm.200911-1698OC. Epub 2010 Apr 15.

  PMID: 20395557 DERIVED

Related Links

• The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease website.

Biospecimen

Retention: SAMPLES WITH DNA

Lung Tissue from a Lung Biopsy ordered by the patients physician. Also, a blood sample may be collected at the researchers discretion as listed in the addendum consent form.

MeSH Terms

Conditions

Pulmonary Fibrosis; Fibrosis

Condition Hierarchy (Ancestors)

Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Kevin F Gibson, MD

  University of Pittsburgh - Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Study Record Dates

• First Submitted: November 23, 2005
• First Posted: November 24, 2005
• Study Start: October 1, 2001
• Primary Completion (Estimated): July 1, 2030
• Study Completion (Estimated): July 1, 2030
• Last Updated: October 30, 2025

Record last verified: 2025-09

Locations

US (1)