NCT00001678

Brief Summary

This study attempts to identify the genes responsible for rheumatoid arthritis (RA), or inflammation of the joints. It is known that genes play an important role in RA, but their number and significance have not been determined. RA tends to run in families. This study will examine the DNA (hereditary material) of patients with RA and their family members to try to determine which chromosomes(s) contain the genes responsible for the disease. Patients with rheumatoid arthritis and their family members may be eligible for this study. Participants with RA who have a brother or sister with RA will undergo the following procedures:

  • Review of their medical records
  • Medical history
  • Examination of the joints
  • Hand X-rays
  • Blood tests Participants who 1) do not have RA but who have a relative with the disease, or 2) have RA and a relative other than a brother or sister who has the disease will provide a blood sample or a buccal (cheek) cell sample. Cheek cells are obtained by swishing a small amount of mouthwash in the mouth or by lightly bushing the inside of the cheek with a swab or brush. The samples will be tested for rheumatoid factor, DNA studies, and HLA type (a blood type found on white blood cells). Certain HLA types have been associated with an increased risk or severity of RA.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
39

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 1998

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 7, 1998

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

November 3, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 4, 1999

Completed
14.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 20, 2014

Completed
Last Updated

October 6, 2017

Status Verified

June 20, 2014

First QC Date

November 3, 1999

Last Update Submit

October 5, 2017

Conditions

Rheumatoid Arthritis

Keywords

AutoimmunitySibling PairsGenesRheumatoid ArthritisBone Erosion

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • SIBLING PAIR:
  • A diagnosis of rheumatoid arthritis in both sibs by the 1987 ACR criteria.
  • Definite bony erosions in at least one affected sibling.
  • Age of disease onset greater than 18 years and less than 60 years in at least one sibling.
  • Neither sibling has psoriasis, inflammatory bowel disease, or systemic lupus erythematosus.
  • BLOOD RELATIVES OF AFFECTED SIBLING PAIRS:
  • Age greater than 18 years.
  • Where possible, all other affected siblings will be invited to participate.
  • Where possible, both parents of affected siblings will be invited to participate.
  • Other relatives, both affected and unaffected, may be invited to participate if, in the opinion of the investigators, samples from these individuals would contribute important genetic information. Two cases in which this might happen are: a) extended families in which there are several affected individuals, where conventional linkage analysis might be applied; b) affected sibling pairs for which parents are unavailable, where additional siblings will provide information on parental alleles not transmitted to the affected siblings.

You may not qualify if:

  • Psoriasis, inflammatory bowel disease, systemic lupus erythematosus.
  • Inability to provide infomed consent.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

  • Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med. 1978 Apr 20;298(16):869-71. doi: 10.1056/NEJM197804202981602.

    PMID: 147420BACKGROUND

  • Lawrence RC, Hochberg MC, Kelsey JL, McDuffie FC, Medsger TA Jr, Felts WR, Shulman LE. Estimates of the prevalence of selected arthritic and musculoskeletal diseases in the United States. J Rheumatol. 1989 Apr;16(4):427-41.

    PMID: 2746583BACKGROUND

  • Harris ED Jr. Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med. 1990 May 3;322(18):1277-89. doi: 10.1056/NEJM199005033221805. No abstract available.

    PMID: 2271017BACKGROUND

MeSH Terms

Conditions

Arthritis, RheumatoidAutoimmune Diseases

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesImmune System Diseases

Study Officials

  • Daniel L Kastner, M.D.

    National Human Genome Research Institute (NHGRI)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

November 3, 1999

First Posted

November 4, 1999

Study Start

July 7, 1998

Study Completion

June 20, 2014

Last Updated

October 6, 2017

Record last verified: 2014-06-20

Locations

US(1)